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U-GEMMs

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Mice

Kras-LSL-G12D

Strain Name：C57BL/6JSmoc-Krasem4(LSL-G12D)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-190003

exon2 of Kras were replaced by loxp-stop-loxp and exon2 containing G12D. When crossed with a Cre recombinase-expressing strain, this strain is useful in studies of cancer and development.

Mice

M-NSG

Strain Name：NOD.Cg-PrkdcscidIl2rgem1Smoc
Strain State：Repository Live | Cat. NO.：NM-NSG-001

Prkdc and Il2rg genes were both knocked-out in NOD mice.  Lacking mature T, B and NK cells Low immune rejection against human cells and tissues Good tumorigenicity so that a small number of cells can form tumors. Significant improvement in the survival of transplanted human cells and tissues Suitable for the transplantation of human hematopoietic stem cells and the preparation of humanized mouse models Suitable as the carrier mice for the transplantation of heterologous cells and tissues

Mice

hPD-1

Strain Name：C57BL/6JSmoc-Pdcd1em1(hPDCD1) /Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-00015

The endogenous mouse Pdcd1 gene was replaced by human PDCD1(PD-1) gene  .

Mice

Alb-CreERT2

Strain Name：B6.129S-Albtm1.1(CreERT2)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-00002

Exons 1-7 were replaced by CreERT2 and a loxp neo casette. The KI mice have a tamoxifen-inducible cre-mediated recombination system.This strain has removed the Neo screening gene.

Mice

hPD-L1

Strain Name：C57BL/6JSmoc-Cd274em1(hPD-L1)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-00062

The endogenous mouse Cd274(also known as PD-L1) gene was replaced by human PD-L1 gene .  While hPD-L1(2)(Stock No.NM-HU-190039) mice function similarly to hPD-L1 mice,for more detailed information please contact our technical advisor.

Mice

R26-CAG-LSL-RSR-tdTomato-2A-DTR

Strain Name：C57BL/6JSmoc-Gt(ROSA)26Sorem1(CAG-LSL-RSR-tdTomato-2A-DTR)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-190086

These mice harbor a CAG-LSL-RSR-tdTomato-2A-DTR cassette in the Rosa26 locus generated by homologous recombination.

Mice

hCD19

Strain Name：C57BL/6JSmoc-Cd19em1(hCD19) Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00110

The endogenous mouse Cd19 gene was replaced by human CD19 gene  .

Mice

hCTLA-4

Strain Name：C57BL/6JSmoc-Ctla4em1(hCTLA4) Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00014

The endogenous mouse Ctal4 gene was replaced by human CTLA4 gene.  While hCTLA4(2)(Stock No.NM-HU-190038) mice function similarly to hCTLA4 mice,for more detailed information please contact our technical advisor.

Mice

Dppa3-IRES-Cre

Strain Name：C57BL/6JSmoc-Dppa3em1(IRES-Cre)Smoc
Strain State：Not for sale | Cat. NO.：NM-KI-00040

The IRES-Cre cassette was inserted into 3'UTR of Dppa(Stella) gene which express during embryonic development.

Mice

hCD38(2)

Strain Name：C57BL/6JSmoc-Cd38em2(CD38)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190059

The endogenous mouse Cd38 gene was replaced by human CD38 gene. While hCD38 mice(Stock No.NM-HU-00113）have been pulled from shelves for some reasons.

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