Gene-editing proposal
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Strain Name: C57BL/6J-Slc6a1em2(S295L)Smoc Mutation Type: Point mutaion Research Application: nervous system,immune system
These mice carry a p.S295L mutation in Slc6a1 gene via CRISPR/Cas mediated recombination.
Strain Name: C57BL/6J-Nlrp3em3Smoc Mutation Type: Knockout Research Application: Immune-related
This Nlrp3 knockout mouse model was generated by knocking out the exon 5 region of the Nlrp3 using CRISPR/Cas technology.
Strain Name: C57BL/6J-Nlrp3em2(flox)Smoc Mutation Type: Conditional knockout Research Application: Immune-related
These mice carry loxP sites flanking exon 5. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of the gene.
Strain Name: C57BL/6J-Mecp2tm2(flox)Smoc Mutation Type: Conditional knockout Research Application: Rett syndrome, autism
These mice carry loxP sites flanking exon 2-3. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of the gene.
Strain Name: C57BL/6J-Il7tm1(hIL7)Smoc Mutation Type: Humanization Research Application: Immunotherapy,cancer research,drug screening
The endogenous mouse Il7 gene was replaced by human IL7 gene via ESC targeting.
Strain Name: C57BL/6J-Il10tm1.1Smoc Mutation Type: Knockout Research Application: immune system
This Il10 knockout strain is established by crossing Il10-CKO and Dppa3-Cre mice strains together. The Il10 flox mice possess loxP sites flanking exons 1 via ESC targeting.
Strain Name: C57BL/6J-Ifngr1em1Ifnar1em1Smoc Mutation Type: Knockout Research Application: immune system
This Ifngr1 and Ifnar1 double knockout strain is established by crossing Ifngr1-KO and Ifnar1-KO mice together.
Strain Name: C57BL/6J-Icosem2(hICOS)Smoc Mutation Type: Humanization Research Application: Immunotherapy,cancer research,drug screening
The endogenous mouse Icos gene was replaced by human ICOS gene via CRISPR/Cas mediated recombination.
Strain Name: C57BL/6J-Cyp3a57em2Cyp3a59em2Cyp3a13em1Smoc Mutation Type: Knockout Research Application:
All genes between Cyp3a57 and Cyp3a59 (including Cyp3a11, Cyp3a16, Cyp3a25, Cyp3a41, Cyp3a44, Cyp3a57, Cyp3a58-ps, Cyp3a59) and Cyp3a13 were knocked out by CRISPR/Cas9 technology.
Strain Name: C57BL/6J-Cd68em2(2A-CreERT2-WPRE-polyA)Smoc Mutation Type: Knock-in Research Application: Tool Mice
This tamoxifen-inducible Cd68-CreERT2 tool mouse model was established by inserting a 2A-CreERT2-WPRE-polyA co-expression cassette into the stop codon of Cd68 gene by CRISPR/Cas9 gene editing technology.