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CTLA4-HU Mouse

Strain Name: C57BL/6J-Ctla4em2(hCTLA4)Smoc Mutation Type: Humanization Research Application: Immunotherapy,cancer research,drug screening

Extracellular domain of mouse Ctla4 gene was replaced by human CTLA4 gene via CRISPR/Cas mediated recombination.

Adipoq-KO Mouse

Strain Name: C57BL/6J-Adipoqem2Smoc Mutation Type: Knockout Research Application: lipid metabolism

Using CRISPR/Cas9 technology, exon 2-3 of Adipoq gene was deleted to generate Adipoq knockout mice.

Tnfrsf14-KO Mouse

Strain Name: C57BL/6J-Tnfrsf14em1Smoc Mutation Type: Knockout Research Application: Immune-related

Using CRISPR/Cas9 technology, exon 2-4 of Tnfrsf14 gene was deleted to generate Tnfrsf14 knockout mice.

PD-L1-HU Mouse

Strain Name: C57BL/6J-Cd274em2(hPD-L1)Smoc Mutation Type: Humanization Research Application: Immunotherapy,cancer research,drug screening

Extracellular domain of mouse Cd274(also known as PD-L1) gene was replaced by human PD-L1 gene via CRISPR/Cas mediated recombination.

R26-(SA-CD46-IRES-tdTomato) Mouse

Strain Name: C57BL/6-Gt(ROSA)26Sorem1(SA-CD46-IRES-tdTomato-polyA)Smoc Mutation Type: Knockin Research Application: Immune-related

These mice harbor a SA-human CD46-IRES-tdTomato-polyA cassette in the Rosa26 locus generated by homologous recombination.

BTLA-HU Mouse

Strain Name: C57BL/6J-Btlaem2(hBTLA)Smoc Mutation Type: Humanization Research Application: Immunotherapy,cancer research,drug screening

Extracellular domain of mouse Btla gene was replaced by human BTLA gene via CRISPR/Cas mediated recombination.

CD81-HU Mouse

Strain Name: C57BL/6J-Cd81em1(CD81)Smoc Mutation Type: Humanization Research Application: Immunotherapy,cancer research,drug screening

The endogenous mouse Cd81 gene was replaced by human CD81 gene via CRISPR/Cas mediated recombination.

DPP4-HU Mouse

Strain Name: C57BL/6J-Dpp4em1(DPP4)Smoc Mutation Type: Humanization Research Application: Immunotherapy,cancer research,drug screening

The endogenous mouse Dpp4 gene was replaced by human DPP4 gene via CRISPR/Cas mediated recombination.

CSF1-HU Mouse

Strain Name: C57BL/6J-Csf1tm2(CSF1)Smoc Mutation Type: Humanization Research Application: Immunotherapy,cancer research,drug screening

The endogenous mouse Csf1 gene was replaced by human CSF1 gene via ESC targeting.

TLR8-HU Mouse

Strain Name: C57BL/6J-Tlr8tm2(TLR8)Smoc Mutation Type: Humanization Research Application: Immunotherapy,cancer research,drug screening

The endogenous mouse Tlr8 gene was replaced by human TLR8 gene via ESC targeting.

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