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U-GEMMs

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Mice

hPD-1

Strain Name：C57BL/6-Pdcd1em1(hPDCD1) /Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-00015

The endogenous mouse Pdcd1 gene was replaced by human PDCD1(PD-1) gene  .

Mice

Kras-LSL-G12D

Strain Name：C57BL/6-Krasem4(LSL-G12D)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-190003

exon2 of Kras were replaced by loxp-stop-loxp and exon2 containing G12D. When crossed with a Cre recombinase-expressing strain, this strain is useful in studies of cancer and development.

Mice

Alb-CreERT2

Strain Name：B6.129S-Albtm1.1(CreERT2)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-00002

Exons 1-7 were replaced by CreERT2 and a loxp neo casette. The KI mice have a tamoxifen-inducible cre-mediated recombination system.This strain has removed the Neo screening gene.

Mice

M-NSG

Strain Name：NOD-Prkdcscid Il2rgem1/Smoc
Strain State：Repository Live | Cat. NO.：NM-NSG-001

Prkdc and Il2rg genes were both knocked-out in NOD mice.  Lacking mature T, B and NK cells Low immune rejection against human cells and tissues Good tumorigenicity so that a small number of cells can form tumors. Significant improvement in the survival of transplanted human cells and tissues Suitable for the transplantation of human hematopoietic stem cells and the preparation of humanized mouse models Suitable as the carrier mice for the transplantation of heterologous cells and tissues

Mice

hPD-L1

Strain Name：C57BL/6-Cd274em1(hPD-L1)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-00062

The endogenous mouse Cd274(also known as PD-L1) gene was replaced by human PD-L1 gene . While hPD-L1(2)(Stock No.NM-HU-190039) mice function similarly to hPD-L1 mice,for more detailed information please contact our technical advisor.

Mice

Mbd5-Flox

Strain Name：B6;129S-Mbd5tm1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-00035

An frt-neo-frt cassette was inserted after exon 15 and  loxP sites was inserted before exon 15 and after the neo cassette. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression o

Mice

Rag1-KO(Rag1-EGFP)

Strain Name：B6;129S-Rag1tm1(loxP-EGFP-PolyA-loxP-Neo-loxP)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-00069

A loxP-EGFP-PolyA-loxP-Neo-loxP expression cassette was knocked into the Rag1 gene start codon site. As a Rag1 knockout mouse model, this stain can be used in subcutaneous inoculation of liver cancer tissues and tumor cells.  Tumors can esaily form and grow. The amount of T and B lymphocytes in peripheral blood of mice was extremely low tested by FACS, which was comparable to or lower than that of Nude mice, and there was a significant difference compared with wild type mice. The pathological sections of HE staining of tumor tissues showed that the tumor sections of Rag1 KO mice and Nude mice were similar. This strain has the potential to replace Nude, NOD-SCID mice as a tumor-bearing mouse model.

Mice

R26-CAG-3XKRAB-dCas9-IRES-EGFP

Strain Name：C57BL/6J-Gt(ROSA)26Sorem1(CAG-Loxp-3xKRAB-dCas9-IRES-EGFP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-18007

These mice harbor a CAG-LSL-3xKRAB-dCas9-IRES-EGFP-WPRE-pA conditional expression cassette in mouse Rosa26 loci via homologous recombination.  This strain can be used in CRISPR mediated target gene transcriptional inhibition (CRISPRi). The loxp-stop-loxp cassette was deleted.

Mice

CAG-LSL-dCas9-SPH-Tg

Strain Name：C57BL/6-Tg(CAG-LSL-dCas9-SPH)Smoc
Strain State：Repository Live | Cat. NO.：NM-TG-00025

Cre-dependent SunTag-p65-HSF1 (SPH) transgenic mice were generated with piggyBac transposon system in F1 zygotes and crossed with wild type C57BL/6 mice., SPH transgenic mouse containing HA-tagged dCas9 fused with 10xGCN4, which is linked with p65-HSF1 and EGFP in tandem via P2A and T2A respectively. The transgene is driven by the ubiquitous CAG promoter and interrupted by a loxP-stop-loxP (LSL) cassette to render Cas9 expression inducible by the Cre recombinase. Expression of dCas9 can be detected using primary antibody: rabbit monoclonal antibody to HA-tag (1:1000, #3724, CST45) and secondary antibody: goat anti-rabbit Alexa Fluor 488 (1:1000, #A-11034, Thermo Fisher).

Mice

Atg5-Flox

Strain Name：C57BL/6-Atg5em2(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-00131

These mice carry loxP sites flanking exon 3 of Atg5 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of this gene.

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