Gene-editing proposal
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Strain Name: C57BL/6-S1pr1em2Smoc Mutation Type: Knockout Research Application: Signal transduction and ceramide pathway related research through GPCR
Using CRISPR/Cas9 technology, exon 2 of S1pr1 gene was deleted to generate S1pr1 knockout mice.
Strain Name: B6.129-1190002N15Riktm1(flox)Smoc Mutation Type: Conditional knockout Research Application:
These mice possess loxP sites on either side of exon 2 and followed by an frt-neo-frt cassette. When crossed with a Cre recombinase-expressing strain,this strain is useful in eliminating tissue-specific conditional expression of the gene.
Strain Name: C57BL/6-1300017j02Rikem1Smoc Mutation Type: Knockout Research Application: Immune-related
This 1300017j02Rik knockout mouse model was generated by knocking out the exon2-12 region of the 1300017j02Rik using CRISPR/Cas technology.
Strain Name: B6.129-1700074P13Riktm1Smoc Mutation Type: Knockout Research Application:
Exons 2-3 were replaced by pGK-Neo cassette.
Strain Name: C57BL/6-1700121C10Rikem1smoc Mutation Type: Knockout Research Application: unknown
Using CRISPR/Cas9 technology, 1700121C10Rik gene was deleted to generate 1700121C10Rik knockout mice.
Strain Name: C57BL/6-2310057M21Rikem1Smoc Mutation Type: Knockout Research Application: Immune-related
This 2310057M21Rik knockout mouse model was generated by knocking out the exon 2-3 region of the 2310057M21Rik using CRISPR/Cas technology.
Strain Name: C57BL/6-Tnfrsf9tm2(TNFRSF9)Smoc Mutation Type: Humanization Research Application: Immunotherapy,Cancer research,Drug screening
The endogenous mouse Tnfrsf9 gene was replaced by human TNFRSF9(4-1BB) gene via ESC targeting. Click here for detailed validation data.
Strain Name: C57BL/6-Tnfrsf9em1Smoc Mutation Type: Knockout Research Application: Immune and hematopoietic research
Using CRISPR/Cas9 technology, gRNAs targeting exon2 of Tnfrsf9 (4-1BB) gene were used to generate Tnfrsf9 (4-1BB) knockout mice.
Strain Name: C57BL/6-Tnfsf9em1(hTNFSF9)Smoc Mutation Type: Humanization Research Application: Immunotherapy,cancer research,drug screening
The endogenous mouse Tnfsf9 gene was replaced by human TNFSF9 gene via CRISPR/Cas mediated recombination.
Strain Name: B6.129-4930578C19Riktm1(flox)Smoc Mutation Type: Conditional knockout Research Application:
These mice possess loxP sites on either side of exon 2 and followed by an frt-neo-frt cassette. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of the gene.