Gene-editing proposal
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Strain Name: C57BL/6-Gt(ROSA)26Sortm1(CAG-Cas9)Smoc Mutation Type: Knock-in Research Application: gene editing, gene modification
These mice were established by crossing R26-(CAG-LSL-Cas9) and EIIA mice together.
Strain Name: C57BL/6J-Csf1rem2(hCSF1R)Smoc Mutation Type: Humanization Research Application: Immunotherapy,Cancer research,Drug screening
The endogenous mouse Csf1r gene was replaced by human CSF1R gene via CRISPR/Cas mediated recombination.
Strain Name: C57BL/6J-Cxcr2em2(hCXCR2)Smoc Mutation Type: Humanization Research Application: Immunotherapy,Cancer research,Drug screening
The endogenous mouse Cxcr2 gene was replaced by human CXCR2 gene via CRISPR/Cas mediated recombination.
Strain Name: C57BL/6J-Ccr2em2(hCCR2)Smoc Mutation Type: Humanization Research Application: Immunotherapy,Cancer research,Drug screening
The endogenous mouse Ccr2 gene was replaced by human CCR2 gene via CRISPR/Cas mediated recombination.
Strain Name: C57BL/6J-Tlr7tm1(hTLR7)Smoc Mutation Type: Humanization Research Application: Immunotherapy,Cancer research,Drug screening
The endogenous mouse Tlr7 gene was replaced by humanTLR7 gene via ESC targeting.
Strain Name: C57BL/6J-Nkx3-1em1(V5-Avi tag-2A-CreERT2)Smoc Mutation Type: Knock-in Research Application: Cre recombinase tool
A V5-Avi tag-2A-CreERT2 expression cassette was knocked into the Nkx3-1 gene stop codon site by homologous recombination.
Strain Name: C57BL/6J-Tertem1(CreERT2-2A-GFP-WPRE-PA)Smoc Mutation Type: Knock-in Research Application: Cre recombinase tool
A CreERT2-2A-GFP-WPRE-PA expression cassette was knocked into the Telt gene start codon site by homologous recombination using CRISPR/Cas9 technology.
Strain Name: C57BL/6J-Gt(ROSA)26Sorem1(CAG-LSL-Kozak-Dusp12-3XFlag-Wpre-pA)Smoc Mutation Type: Knock-in Research Application:
A CAG promoter-LSL-Kozak-Dusp12-3XFlag-Wpre-pA expression cassette was inserted at the Rosa26 locus site using CRISPR gene editing technology.
Strain Name: C57BL/6J-Npc1em1(I1060T)Smoc Mutation Type: Point mutaion Research Application:
The I1060T point mutation is located in exon21 of mouse Npc1 gene. This Npc1 point mutation mouse model was established by introduce a T>C transversion at the 138th nucleotide of exon21 via CRISPR-mediated gene editing technology.
Strain Name: C57BL/6J-Gbaem1(D427v)Smoc Mutation Type: Point mutaion Research Application:
The D427V point mutation is located in exon9 of mouse Gba gene. This Gba point mutation mouse model was established by introduce an A>T transversion at the 119th nucleotide of exon9 via CRISPR-mediated gene editing technology.