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R26-(CAG-LSL-HER2-luciferase-EGFP) Mouse

Strain Name: C57BL/6J-Gt(ROSA)26Sorem1(SA-2xpolyA-CAG-LSL-HER2-luciferase-EGFP)Smoc Mutation Type: Knock-in Research Application:

A SA-2xpolyA-CAG-LSL-HER2-IRES-Luciferase-2A-EGFP-WPRE-polyA cassette was inserted at the Rosa26 locus using CRISPR gene editing technology. When bred to a strain expressing Cre recombinase under control of various tissue specific promoters, Cre recombination deletes the LSL cassette and allows the expression of the HER2 protein.

R26-(CAG-LSL-EGFR T790M-del19-luciferase-tdTomato) Mouse

Strain Name: C57BL/6J-Gt(ROSA)26Sorem1(SA-2xpolyA-CAG-LSL-EGFR T790M-del19-luciferase-tdTomato)Smoc Mutation Type: Knock-in Research Application:

A SA-2xpolyA-CAG-LSL-EGFR(T790M-del19)-IRES-luciferase-2A-tdTomato-WPRE-polyA cassette was inserted at the Rosa26 locus using CRISPR gene editing technology. When bred to a strain expressing Cre recombinase under control of various tissue specific promoters, Cre recombination deletes the LSL cassette and allows the expression of the EGFR(T790M-del19) protein.

R26-(CAG-LSL-EML4-ALK(F1174L)-luciferase-tdTomato) Mouse

Strain Name: C57BL/6J-Gt(ROSA)26Sorem1(SA-2xpolyA-CAG-LSL-EML4-ALK(F1174L)-IRES-luciferase-2A-tdTomato)Smoc Mutation Type: Knock-in Research Application:

A SA-2xpolyA-CAG-LSL-EML4-ALK(F1174L)-IRES-Luciferase-2A-tdTomato-WPRE-polyA cassette was inserted at the Rosa26 locus using CRISPR gene editing technology. When bred to a strain expressing Cre recombinase under control of various tissue specific promoters, Cre recombination deletes the LSL cassette and allows the expression of the EML4-ALK(F1174L) protein.

Il5-HU Mouse

Strain Name: C57BL/6J-Il5tm3(hIL5)Smoc Mutation Type: Humanization Research Application: Immune-related

This IL5 humanized mouse model was established by replacing the mouse Il5 gene coding exons and introns with the human TLR9 corresponding sequence by homologous recombination via ES cell targeting.

APOE4-HU Mouse

Strain Name: C57BL/6J-Apoetm2(hAPOE4)Smoc Mutation Type: Humanization Research Application: Cardiovascular disease

This APOE4 humanized mouse model was established by replacing the mouse Apoe gene coding exons and introns with the human APOE4 corresponding sequence by homologous recombination via ES cell targeting.

APOE3-HU Mouse

Strain Name: C57BL/6J-Apoetm3(hAPOE3)Smoc Mutation Type: Humanization Research Application: Cardiovascular disease

This APOE3 humanized mouse model was established by replacing the mouse Apoe gene coding exons and introns with the human APOE3 corresponding sequence by homologous recombination via ES cell targeting.

Slc17a6-(CreERT2) Mouse

Strain Name: C57BL/6J-Slc17a6em2(CreERT2)Smoc Mutation Type: Knock-in Research Application: Tool Mice

This tamoxifen-inducible Slc17a6-CreERT2 tool mouse model was established by inserting a 2A-CreERT2-WPRE-polyA co-expression cassette into the stop codon of Slc17a6 gene by CRISPR/Cas9 gene editing technology.

VTCN1-HU Mouse

Strain Name: C57BL/6J-Vtcn1em1(hVTCN1)Smoc Mutation Type: Humanization Research Application: Immune-related

This VTCN1 humanized mouse model was established by replacing the mouse Vtcn1 gene with the human VTCN1 via CRISPR gene editing technology.

Amhr2-(Cre) Mouse

Strain Name: C57BL/6J-Amhr2em1(cre)Smoc Mutation Type: Knock-in Research Application: Tool Mice

A IRES-iCre-WPRE-polyA coexpression cassette is inserted after the stop codon of mouse Amhr2 gene via homologous recombination to establish a Amhr2-Cre tool stain. This strain can be used to knockout target gene in Amhr2+ cells when crossed with mice which carry loxp sites flanking target gene.

Foxn1-KO Mouse

Strain Name: NOD-PrkdcscidIl2rgem1Foxn1tm1Smoc Mutation Type: Knockout Research Application: Immune-related

This immunodeficient mice model was generated by knocking out the exon3-5 region of the Foxn1 on M-NSG mouse using ESC targeting technology.

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