NOD-Prkdcscid Il2rgem1/Smoc

Cat. NO.


Strain State

Repository Live

Gene Summary

Official Symbol

Model Description

Prkdc and Il2rg genes were both knocked-out in NOD mice. 

  • Lacking mature T, B and NK cells
  • Low immune rejection against human cells and tissues
  • Good tumorigenicity so that a small number of cells can form tumors.
  • Significant improvement in the survival of transplanted human cells and tissues
  • Suitable for the transplantation of human hematopoietic stem cells and the preparation of humanized mouse models
  • Suitable as the carrier mice for the transplantation of heterologous cells and tissues
Research Application:Immune and hematopoietic research

Validation Data

Login to view data

You may also like


Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

Learn more
Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

Learn more