hPD-L1(2)

Nomenclature

C57BL/6Smoc-Cd274em2(hPD-L1)Smoc

Cat. NO.

NM-HU-190039

Strain State

Embryo cryopreservation

Export PDF

Gene Summary

Gene Symbol
Cd274

Model Description

Extracellular domain of mouse Cd274(also known as PD-L1) gene was replaced by human PD-L1 gene. While hPD-L1(Stock No.NM-HU-00062) mice function similarly to hPD-L1(2) mice,for more detailed information please contact our technical advisor.
Research Application:Immunotherapy,cancer research,drug screening

Validation Data


PD-L1-HU-1.png

Fig1. The expression of human PD-L1 in the peripheral blood cells derived from homozygous humanized mice were confirmed by flow cytometry analysis. 

image.png

Fig2. Immunotype in blood , spleen and bone marrow in hPD-L1 mice.  

image.png

Fig3. Immunotype in blood in hPD-L1 mice. 

image.png


Fig4. Immunotype in spleen in hPD-L1 mice. 

image.png

Fig5. Immunotype in bone marrow in hPD-L1 mice. 

PD-L1-HU-2.png

PD-L1-HU-3.png

Fig6.  In vivo anti-tumor effect of an anti-human PD-L1 antibody in the humanized PD-L1 mouse model. (Tecentriq is a monoclonal antibody specific for human PD-L1)(A)  PD-L1 humanized MC38 cells were subcutaneously implanted into humanized PD-L1 mouse model. Treatment of hPD-L1 antibody inhibited PD-L1 humanized MC38 tumor growth, demonstrating that the humanized PD-L1 mice are a good in vivo model for validating the efficacy of antibodies targeting human PD-L1. (B) Mean body weight of mice.  All quantitative data are represented as mean ± SEM.


You may also like

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

Learn more
Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

Learn more