hPCSK9
Nomenclature
C57BL/6Smoc-Pcsk9em2(hPCSK9)/Smoc
Cat. NO.
NM-HU-00075
Strain State
Repository Live
Gene Summary
Gene Symbol
Pcsk9
Model Description
Validation Data
Fig1 Expression of PCSK9 in the serum of humanized PCSK9 homozygous mice is detected by Elisa. a The expression of human PCSK9 can be detected in the serum collected from homozygous mice . B The expression of mouse PCSK9 can not be detected in the serum collected from homozygous mice .
Fig2 Impact of evolocumab treatment on CHOL and LDL-C levels in humanized PCSK9 homozygous mice. A single intravenous injection of evolocumab reduced CHOL(a) and LDL-C(b) in humanized PCSK9 homozygous mice after 16 weeks of high-fat diet feeding. Average + SD; n = 6 to 7 mice per condition; *p<0.05, **p<0.01; (Student’s t test).
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On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
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