Lepr-(109052G>T)


Strain Information

Strain Name

B6.129-Leprtm1Smoc

Cat. NO.

NM-KI-00001

Gene Symbol

Lepr

Gene Synonyms

db, Obr, obl, Leprb, Modb1, LEPROT, OB-RGRP, diabetes, obese-like

Human Ortholog

LEPR

Ensembl ID

MGI ID

NCBI ID


Description

A point mutation was introduced to exon 19 (c.109052 G>T) via a recombineering strategy. Homozygous mutants are hyperphagic, low-activity, poorly cold-adapted, sterile and have enhanced fat conversion.

Research application

Leptin resistance,insulin resistance,obesity,and type 2 diabetes etc.

Status

Availability

Embryo cryopreservation


Related Articles

Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

查看
Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

查看
Contact us Email Gene-editing proposal Gene-editing proposal Back to top Back to top