Calm1-KO


Strain Information

Strain Name

C57BL/6J-Calm1em1Smoc

Cat. NO.

NM-KO-190703

Gene Symbol

Calm1

Gene Synonyms

CaM, Calm, Cam1, AI256814, AI327027, AI461935, AL024000

Human Ortholog

CALM1

Ensembl ID

MGI ID

NCBI ID


Description

Using CRISPR/Cas9 technology,exon 2 of Calm1 gene was deleted to generate Calm1 knockout mice.

Research application

The encoded protein acts as a calcium sensor and is involved in relaying signals to calcium-sensitive proteins, enzymes and ion channels. The protein-calcium complex binds target proteins to regulate several cellular processes, including smooth muscle contraction, inflammation, apoptosis and the immune response. Mutations in the human gene are associated with catecholaminergic polymorphic ventricular tachycardia and long QT syndrome 14.

Status

Availability

Embryo cryopreservation


Related Articles

Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

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Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

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