Fhit-KO


Strain Information

Strain Name

C57BL/6J-Fhitem1Smoc

Cat. NO.

NM-KO-190624

Gene Symbol

Fhit

Gene Synonyms

Fra14A2, AW045638

Human Ortholog

FHIT

Ensembl ID

MGI ID

NCBI ID


Description

Using CRISPR/Cas9 technology,exon 4 of Fhit gene was deleted to generate Fhit knockout mice.

Research application

The protein encoded by this gene is a P1-P3-bis(5'-adenosyl) triphosphate hydrolase involved in purine metabolism.  In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. The encoded protein is also a tumor suppressor, as loss of its activity results in replication stress and DNA damage.

Status

Availability

Repository Live


Related Articles

Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

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Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

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