Cdkn3-KO


Strain Information

Strain Name

C57BL/6J-Cdkn3em1Smoc

Cat. NO.

NM-KO-190622

Gene Symbol

Cdkn3

Gene Synonyms

KAP, 2410006H10Rik

Human Ortholog

CDKN3

Ensembl ID

MGI ID

NCBI ID


Description

Using CRISPR/Cas9 technology,exon 3 of Cdkn3 gene was deleted to generate Cdkn3 knockout mice.

Research application

The protein encoded by this gene belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Status

Availability

Sperm cryopreservation


Related Articles

Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

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Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

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