Cdkn2b-KO


Strain Information

Strain Name

C57BL/6J-Cdkn2Bem1Smoc

Cat. NO.

NM-KO-190621

Gene Symbol

Cdkn2b

Gene Synonyms

p15, MTS2, INK4b, AV083695, p15INK4b, p15(INK4b)

Human Ortholog

CDKN2B

Ensembl ID

MGI ID

NCBI ID


Description

Using CRISPR/Cas9 technology,exon 2 of Cdkn2b gene was deleted to generate Cdkn2b knockout mice.

Research application

This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression.

Status

Availability

Sperm cryopreservation


Related Articles

Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

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Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

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