Cdk4-KO


Strain Information

Strain Name

C57BL/6J-Cdk4em1Smoc

Cat. NO.

NM-KO-190614

Gene Symbol

Cdk4

Gene Synonyms

Crk3

Human Ortholog

CDK4

Ensembl ID

MGI ID

NCBI ID


Description

Using CRISPR/Cas9 technology,exon 3-7 of Cdk4 gene was deleted to generate Cdk4 knockout mice.

Research application

The protein encoded by this gene is a member of the Ser/Thr protein kinase family.It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb).

Status

Availability

Sperm cryopreservation


Related Articles

Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

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Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

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