Cckbr-KO


Strain Information

Strain Name

C57BL/6-Cckbrem1Smoc

Cat. NO.

NM-KO-190609

Gene Symbol

Cckbr

Gene Synonyms

CCK2R, CCK-BR, CCK2-R, CCKR-2

Human Ortholog

CCKBR

Ensembl ID

MGI ID

NCBI ID


Description

Using CRISPR/Cas9 technology,exon 3 of Cckbr gene was deleted to generate Cckbr knockout mice.

Research application

This gene encodes a G-protein coupled receptor for gastrin and cholecystokinin (CCK), regulatory peptides of the brain and gastrointestinal tract. This protein is a type B gastrin receptor, which has a high affinity for both sulfated and nonsulfated CCK analogs and is found principally in the central nervous system and the gastrointestinal tract. A misspliced transcript variant including an intron has been observed in cells from colorectal and pancreatic tumors.

Status

Availability

Embryo cryopreservation


Related Articles

Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

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Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

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