Ccr1-KO

Nomenclature

C57BL/6Smoc-Ccr1em1Smoc

Cat. NO.

NM-KO-190768

Strain State

Sperm cryopreservation

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Gene Summary

Gene Symbol
Ccr1

Synonyms

Cmkbr1; Mip-1a-R

NCBI ID

12768

MGI ID

104618

Ensembl ID

ENSMUSG00000025804

Pubmed

Ccr1

Human Ortholog

CCR1

Model Description

Exon 2 of Ccr1 gene was deleted to generate Ccr1 knockout mice.
Research Application：Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite.

Disease Connection

Coronavirus Infectious Disease

Phenotype(s)

MGI:3614443

Reference(s)

Sheahan T, Morrison TE, Funkhouser W, Uematsu S, Akira S, Baric RS, Heise MT, MyD88 is required for protection from lethal infection with a mouse-adapted SARS-CoV. PLoS Pathog. 2008 Dec;4(12):e1000240

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Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

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