App-KO


Strain Information

Strain Name

C57BL/6J-Appem1Smoc

Cat. NO.

NM-KO-190444

Gene Symbol

App

Gene Synonyms

Ag, Abpp, Adap, Cvap, Abeta, betaApp, E030013M08Rik

Human Ortholog

APP

Ensembl ID

MGI ID

NCBI ID


Description

Using CRISPR/Cas9 technology, exon 3 of App gene was deleted to generate App knockout mice.

Research application

neuronal differentiation/migration, synaptic regulation and Alzheimer's disease related

Status

Availability

Repository Live


Related Articles

Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

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Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

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