MHC ClassII(I-A/I-E)-KO(NMG)

Nomenclature

NOD-PrkdcscidIl2rgem1H2-Ab1em1H2-Aaem1H2-Eb1em1H2-Eb2em1H2-Ea-ps em1Smoc

Cat. NO.

NM-NSG-003

Strain State

Developing

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Gene Summary

Gene Symbol
H2-Ab1，H2-Aa，H2-Eb1，H2-Eb2，H1-Ea-ps

Synonyms

Abeta A beta H-2Ab H2-Ab Ia2 Ia-2 IAb I-Ab I-Abeta Rmcs1，Aalpha A alpha H-2Aa Ia1 Ia-1 I-Aalpha，H-2Eb Ia4 Ia-4，A130038H09Rik H-2Eb2 Ia5 Ia-5，H-2Ea Ia3 Ia-3 I-Ealpha

NCBI ID

14961，14960，14969，381091，100504404

MGI ID

103070，95895，95901，95902，95900

Ensembl ID

ENSMUSG00000073421，ENSMUSG00000036594，ENSMUSG00000060586 ，ENSMUSG00000067341，ENSMUSG00000036322

Pubmed

H2-Ab1，H2-Aa，H2-Eb1，H2-Eb2，H1-Ea-ps

Human Ortholog

HLA-DQB1，HLA-DQA1，HLA-DRB5，HLA-DRA

Model Description

All sequences from the upstream of  mouse H2-Ab1 gene exon 2  to the upstream of the H2-Ea-ps gene  exon 1 were knocked out to obtain H2-Ab1、H2-Aa、H2-Eb1、H2-Eb2、H2-Ea-ps knockout mouse models.  These MHC class II molecule-deficient mice were on the NMG genetic background and also lacked cell surface expression of both class II-A and class II-E MHC proteins.

Research Application：immunodeficiency,immune system,transplantation research

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