Lyz2-IRES-DTRGFP

Nomenclature

C57BL/6Smoc-Lyz2em3(IRES-DTREGFP)Smoc

Cat. NO.

NM-KI-190041

Strain State

Repository Live

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Gene Summary

Gene Symbol
Lyz2

Synonyms

Lys; Lzm; Lzp; Lysm; Lyzs; Lyzf2; Lzm-s1; AI326280

NCBI ID

17105

MGI ID

96897

Ensembl ID

ENSMUSG00000069516

Pubmed

Lyz2

Human Ortholog

LYZ2

Model Description

A IRES-DTREGFP expression cassette was knocked into the Lyz2 gene stop codon site.
Research Application：DTR mouse

Validation Data

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Fig1. Analysis of GFP expression by FACS . The Lyz2-DTRGFP mouse expresses GFP on CD11b+ cells.


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Fig2. Analysis of the level of different immune cells in PBMC by FACS (See Figure 4 for details of diphtheria toxin injection). 


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Fig3. Analysis of the level of different immune cells in the spleen and transplanted tumor by FACS (See Figure 4 for details of diphtheria toxin injection). 

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Fig4. The growth of MC38 tumors in Lyz2-DTRGFP mice and C57BL/6 mice. 

Heterozygous Lyz2-DTRGFP mice and C57BL/6 mice were inoculated with MC38 colon cancer cells.  The Lyz2-DTRGFP mice were injected with diphtheria toxin twice a week.

 The data is provided by Crownbio.

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