H11-(pThy1-PSEN1-IRES-tdTomato)


Strain Information

Strain Name

C57BL/6-Igs2em1(pThy1-PSEN1-IRES-tdTomato-WPRE-pA)Smoc

Cat. NO.

NM-KI-18049

Gene Symbol

Gene Synonyms

Human Ortholog

Ensembl ID

MGI ID

NCBI ID


Description

A Thy1 promoter-PSEN1-IRES-tdTomato-WPRE-polyA cassette was knocked into the Igs2 locus (Hipp11 or H11; an intergenic region on chromosome 11 [cytoband A1 at ~3cM between the Eif4enif1 and Drg1 loci] reported to support high-level global gene expression in conjunction with the CAG (CAGGS) promoter and a higher rate of mitotic/interchromosomal recombination compared to Gt(ROSA)26Sor) by CRISPR/Cas9 gene editing technology.

Research application

Alzheimer's research

Status

Availability

Repository Live


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On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

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