H2-Ab1/H2-Ea-ps-KO(Nod-Scid)


Strain Information

Strain Name

NOD.Cg-PrkdcscidH2-Ab1em1Smoc H2-Ea-psem1 Smoc

Cat. NO.

NM-KO-18057

Gene Symbol

H2-Ab1,H2-Ea-ps

Gene Synonyms

Abeta, A beta, H-2Ab, H2-Ab, Ia2, Ia-2, IAb, I-Ab, I-Abeta, Rmcs1,H-2Ea, Ia3, Ia-3, I-Ealpha

Human Ortholog

HLA-DQB1,HLA-DRA

MGI ID

NCBI ID


Description

All sequences from the upstream of mouse H2-Ab1 gene exon 2 to the upstream of the H2-Ea-ps gene exon 1 were knocked out by CRISPR gene editing technology to obtain H2-Ab1 and H2-Ea-ps double knockout mouse models. These MHC class II molecule-deficient mice were on the Nod-Scid genetic background and lacked cell surface expression of both class II-A and class II-E MHC proteins.

Research application

immune system

Status

Availability

Repository Live


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Milestones

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