Npc1-(I1060T)


Strain Information

Strain Name

C57BL/6J-Npc1em1(I1060T)Smoc

Cat. NO.

NM-KI-18059

Gene Symbol

Npc1

Gene Synonyms

spm, lcsd, C85354, nmf164, D18Ertd139e, D18Ertd723e, A430089E03Rik

Human Ortholog

NPC1

MGI ID

NCBI ID


Description

The I1060T point mutation is located in exon21 of mouse Npc1 gene.   This Npc1 point mutation mouse model was established by introduce a T>C transversion at the 138th nucleotide of exon21  via CRISPR-mediated gene editing technology.


Research application


Status

Availability

Repository Live


Related Articles

Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

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Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

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