The F9 gene is located on the X chromosome. In this F9 knockout mouse model, gRNAs were designed targeting exon8 of F9 gene via CRISPR gene editing technology. Loss of F9 caused coagulopathy in mice. Mice that are homozygous for F9 knockout are viable, fertile and normal in size. Normal fighting in the cage may cause bleeding or even death due to massive internal hemorrhaging. After the tail cutting, wounds must be cauterized to prevent homozygous knockout mice from blood loss and death. This strain is a powerful model for studying coagulopathy, gene therapy methods and function of factor IX mutations.
The Company will be embarking on a brand upgrade project from April 2018 to better serve our clients. "南模生物 (Shanghai Model Organisms)" will be adopted as the Company's Chinese brand name, together with a new corporate logo. This will coincide with the launch of a new corporate website: www.modelorg.com.查看