B2m-KO(NOD-scid)


Strain Information

Strain Name

NOD-PrkdcscidB2mem1Smoc

Cat. NO.

NM-KO-18035

Gene Symbol

B2m

Gene Synonyms

beta2-m, beta 2 microglobulin, Ly-m11

Human Ortholog

B2M

Ensembl ID

MGI ID

NCBI ID


Description

This B2m knockout mouse model was obtained by knocking out the exon 2-3 region of mouse B2m gene on the background of Nod-scid mice using CRISPR gene editing technology.  This strain is an ideal model for xenograft transplantation studies and is an excellent source for insulitis-free, MHC class I-negative islets for transplantation studies.


Research application

immunodeficiency,immune system,transplantation research

Status

Availability

Repository Live


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Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

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Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

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