Intestinal expression of the CYP3A enzyme in the human body can cause significant intestinal metabolism of the compound, resulting in impaired drug absorption. This knock-in model was generated by inserting the human CYP3A4 cDNA driven by the Villin1 promoter together with the IRES-tdTomato reporter gene into mosue Rosa26 site, which can be crossed with the Cyp3a13 gene knockout and other Cyp3a family genes knockout mice to obtain intestinal-expressed CYP3A4 humanized mouse model in order to determine the contribution of intestinal metabolism to the absorption and distribution of test article.
The Company will be embarking on a brand upgrade project from April 2018 to better serve our clients. "南模生物 (Shanghai Model Organisms)" will be adopted as the Company's Chinese brand name, together with a new corporate logo. This will coincide with the launch of a new corporate website: www.modelorg.com.查看