This knock-in model was generated by inserting the human CYP3A4 cDNA driven by the liver-specific APOE promoter into the mouse Rosa26 site, which can be used to obtain liver-expressed CYP3A4 humanized model after mating with the Cyp3a13 gene and other Cyp3a family gene knockout mice. This model can be used with NM-KI-18033 mice which has gut-specific expression of human CYP3A4 to compare the contribution of intestinal versus hepatic metabolism to the biotransformation of a test article.
The Company will be embarking on a brand upgrade project from April 2018 to better serve our clients. "南模生物 (Shanghai Model Organisms)" will be adopted as the Company's Chinese brand name, together with a new corporate logo. This will coincide with the launch of a new corporate website: www.modelorg.com.查看