R26-(Liver-CYP3A4)


Strain Information

Strain Name

FVB-Gt(ROSA)26Sorem1(Liver-CYP3A4)Smoc

Cat. NO.

NM-KI-18032

Gene Symbol

CYP3A4

Gene Synonyms

HLP, CP33, CP34, CYP3A, NF-25, CYP3A3, P450C3, CYPIIIA3, CYPIIIA4, P450PCN1

Human Ortholog

CYP3A4

Ensembl ID

MGI ID

NCBI ID


Description

This knock-in model was generated by inserting the human CYP3A4 cDNA driven by the liver-specific APOE promoter into the mouse Rosa26 site, which can be used to obtain liver-expressed CYP3A4 humanized model after mating with the Cyp3a13 gene and other Cyp3a family gene knockout mice. This model can be used with NM-KI-18033 mice which has gut-specific expression of human CYP3A4 to compare the contribution of intestinal versus hepatic metabolism to the biotransformation of a test article.


Research application

metabolism

Status

Availability

Repository Live


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Milestones

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On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

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