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Repository of Research-Ready GEM models

We offer 2000+ Research-Ready mouse models to jump start your mouse experiments. Browse the strain list by application, or directly search for the strain of your interest.

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We offer 2000+ Research-Ready mouse models to jump start your mouse experiments. Browse the strain list by application, or directly search for the strain of your interest.
Name Cat. NO. Gene Symbol Research Application
1190002N15Rik-CKO NM-CKO-00008 1190002N15Rik
1300017j02Rik-KO NM-KO-190231 1300017j02Rik Immune-related
1700074P13Rik-KO NM-KO-00025 1700074P13Rik
1700121C10Rik-KO NM-KO-190450 1700121C10Rik unknown
2310057M21Rik-KO NM-KO-190232 2310057M21Rik Immune-related
4930578C19Rik-CKO NM-CKO-00003 4930578C19Rik
9430015G10Rik-KO NM-KO-191133 9430015G10Rik Immune system, nervous system, pain
a-(IRES-Cre) NM-KI-200027 a Cre recombinase tool
A2m-KO NM-KO-190549 A2m Beta-amyloid metabolism related;Alzheimer's disease research related
A4galt-KO NM-KO-200001 A4galt Therapeutic antibody target
Aak1-KO NM-KO-200002 Aak1 Therapeutic antibody target
Abcb11-KO NM-KO-18010 Abcb11
Abcb5-KO NM-KO-200003 Abcb5 Therapeutic antibody target
Abcc1-KO NM-KO-18012 Abcc1
Abcc2-KO NM-KO-18017 Abcc2
Abcc3-KO NM-KO-200004 Abcc3 Therapeutic antibody target
Abcc6-KO NM-KO-200005 Abcc6 Therapeutic antibody target
Abcg2-KO NM-KO-18013 Abcg2
Abi3bp-CKO NM-CKO-00009 Abi3bp Cancer and stem cells research
Abtb1-KO NM-KO-00001 Abtb1 liver injury and regeneration
Acadsb-KO NM-KO-190233 Acadsb Immune-related
Ace-KO NM-KO-190550 Ace Cardiovascular diseases;diabetes related
Ace2-KO NM-KO-190906 Ace2 regulation of cardiovascular and renal function, as well as fertility , Cardiac contraction, colitis, cardiovascular and renal function, and fertility
H11-(ACHE) NM-KI-00067 ACHE Cholinesterase related drug research
Acot7-CKO NM-CKO-00045 Acot7 Biosynthesis of unsaturated fatty acids,Fatty acid elongation,fatty acid metabolism
Acp2-KO NM-KO-200006 Acp2 Therapeutic antibody target
Acta2-KO NM-KO-190907 Acta2 Vasoconstriction, blood pressure, retinal barrier permeability, retinal cone and rod function
Acvr2a-KO NM-KO-200007 Acvr2a Therapeutic antibody target
Adam15-KO NM-KO-200008 Adam15 Therapeutic antibody target
Adam28-KO NM-KO-200009 Adam28 Therapeutic antibody target
Adam33-KO NM-KO-190735 Adam33 Asthma related
Adam8-KO NM-KO-200010 Adam8 Therapeutic antibody target
Adam9-KO NM-KO-190736 Adam9 Alzheimer's Disease related
Adamts13-KO NM-KO-200011 Adamts13 Therapeutic antibody target
Adamts2-KO NM-KO-200012 Adamts2 Therapeutic antibody target
Adamts4-KO NM-KO-200013 Adamts4 Therapeutic antibody target
Adamts5-KO NM-KO-200014 Adamts5 Therapeutic antibody target
Adat2-KO NM-KO-200015 Adat2 Therapeutic antibody target
Adcyap1r1-KO NM-KO-190669 Adcyap1r1 immune，nervous system
Adgra1-CKO NM-CKO-00100 Adgra1 cardiovascular system，nervous system
Adgra2-CKO NM-CKO-00101 Adgra2
Adgrd1-KO NM-KO-190234 Adgrd1 Immune-related
Adgrd1-CKO NM-CKO-00097 Adgrd1
Adgre1-KO NM-KO-200016 Adgre1 Therapeutic antibody target
Adgre1-(2A-CreERT2) NM-KI-190025 Adgre1 Cre recombinase tool
Adgrf1-KO NM-KO-00059 Adgrf1
Adgrf4-KO NM-KO-00055 Adgrf4
Adgrf5-CKO NM-CKO-00095 Adgrf5 cardiovascular system，homeostasis/metabolism，aging
Adgrg2-KO NM-KO-200017 Adgrg2 Therapeutic antibody target
Adgrg3-KO NM-KO-00054 Adgrg3
Adgrg6-CKO NM-CKO-00096 Adgrg6
Adgrg7-KO NM-KO-00056 Adgrg7 Digestive system related.
Adipoq-KO NM-KO-190438 Adipoq lipid metabolism
Adipoq-KO NM-KO-00003 Adipoq lipid metabolism
Adipor1-KO NM-KO-190666 Adipor1 obesity，diabetes
Adipor2-KO NM-KO-190667 Adipor2 obesity，diabetes
Ado-KO NM-KO-190236 Ado Immune-related
Adora2a-KO NM-KO-200018 Adora2a Therapeutic antibody target
Adora2b-KO NM-KO-191066 Adora2b Immune system, inflammation
Adra1a-KO NM-KO-190737 Adra1a Diabetes related
Adra1d-KO NM-KO-190908 Adra1d Nervous system, behavior, neuronal growth and cerebellar development, neurological and mental disorders
Adra2a-KO NM-KO-191174 Adra2a member of the G protein-coupled receptor superfamily.
Adra2b-KO NM-KO-190635 Adra2b nervous system
Adrb2-KO NM-KO-190738 Adrb2 Asthma related
Adrb3-KO NM-KO-190739 Adrb3 Diabetes related
Adtrp-KO NM-KO-200019 Adtrp Therapeutic antibody target
Afp-KO NM-KO-200020 Afp Therapeutic antibody target
Afp-CreERT2 NM-TG-00009 Afp-CreERT2 Cre recombinase tool of liver
Ager-KO NM-KO-200021 Ager Therapeutic antibody target
Agk-CKO NM-CKO-00026 Agk
Agr3-KO NM-KO-190237 Agr3 Immune-related
Agrp-KO NM-KO-190636 Agrp late on-set obesity
Agrt1a-KO NM-KO-00041 Agrt1a cardiovascular system,nervous system
Agt-KO NM-KO-190740 Agt This gene is associated with susceptibility to essential hypertension, non-familial structural atrial fibrillation, and inflammatory bowel disease.
Agtr1a-KO NM-KO-190909 Agtr1a Renal morphology and function, xenobiotic response, hyperreninemia, drinking behavior, angiotensin II-related vascular and hemodynamic responses
Agtr1b-KO NM-KO-190910 Agtr1b Agtr1b/Agtr1a double gene function, blood pressure and kidney
Agtr2-KO NM-KO-190911 Agtr2 Angiotensin II response, pancreatitis, myocardial infarction; cardiovascular morphology and physiology, kidney and urine morphology and physiology; glucose and fat metabolism and balance; X-linked cognitive impairment
Ahcy-KO NM-KO-190238 Ahcy Immune-related
Ahi1-CKO NM-CKO-00053 Ahi1
Ahnak-KO NM-KO-190239 Ahnak Immune-related
Ahr-KO NM-KO-18008 Ahr
AI467606-KO NM-KO-200022 AI467606 Therapeutic antibody target
Aifm1-KO NM-KO-191170 Aifm1 Mutations in this gene cause combined oxidative phosphorylation deficiency 6 (COXPD6), a severe mitochondrial encephalomyopathy, as well as Cowchock syndrome, also known as X-linked recessive Charcot-Marie-Tooth disease-4 (CMTX-4), a disorder resulting in neuropathy, and axonal and motor-sensory defects with deafness and cognitive disability.
Aimp1-CKO NM-CKO-00064 Aimp1 immune system，hematopoietic system
Ajuba-KO NM-KO-190912 Ajuba Cancer, breast cancer, glioma
Akt1-KO NM-KO-190741 Akt1 Pro-Inflammatory, Anti-Apoptotic and Stress Responses related.
Akt1s1-KO NM-KO-191102 Akt1s1 Ischemic brain injury; tumor
Akt2-KO NM-KO-190742 Akt2 Signal Transduction related
Akt3-KO NM-KO-191091 Akt3 Cell proliferation, differentiation, apoptosis, tumorigenesis, glycogen synthesis and glucose uptake; nervous system, brain development, epilepsy
ALB-HU NM-HU-200003 Alb Drug screening
Alb-KO NM-KO-200023 Alb Therapeutic antibody target
Alb-(CreERT2) NM-KI-00002 Alb cre-mediated recombination system
Alcam-KO NM-KO-200024 Alcam Therapeutic antibody target
Aldh3a2-KO NM-KO-190743 Aldh3a2 Nervous System Differentiation & Development related
Aldoc-KO NM-KO-191089 Aldoc Glycolysis enzyme, nervous system, schizophrenia
Alk-KO NM-KO-200025 Alk Therapeutic antibody target
Alkbh3-KO NM-KO-190240 Alkbh3 Immune-related
Alkbh5-KO NM-KO-190448 Alkbh5 mRNA methylation
R26-(CAG-LSL-ALKBH5-3xFLAG-IRES-EGFP) NM-KI-190054 Alkbh5 mRNA methylation
Alkbh5-CKO NM-CKO-190004 Alkbh5 Epigenetic
Alpl-KO NM-KO-18058 Alpl
Amh-KO NM-KO-200026 Amh Therapeutic antibody target
Amhr2-KO NM-KO-200027 Amhr2 Therapeutic antibody target
Amhr2-(Cre) NM-KI-190012 Amhr2 Tool Mice
Amotl1-KO NM-KO-190913 Amotl1 Peripheral permeability and maintenance of cell polarity, angiomotin-related,
Amotl2-KO NM-KO-190914 Amotl2 Angiotensin-related, endothelial cell function, embryonic aortic restriction
Angel2-KO NM-KO-190744 Angel2 Inflammatory Response, aging related.
Angptl3-KO NM-KO-200028 Angptl3 Therapeutic antibody target
Angptl4-KO NM-KO-191067 Angptl4 Metabolic system, glucose homeostasis, lipid metabolism; tumor
Angptl8-KO NM-KO-190241 Angptl8 Immune-related
Ankrd37-KO NM-KO-191087 Ankrd37 Hypoxia-induced HIF-1 target gene
Anp32b-CKO NM-CKO-00043 Anp32b
Anpep-KO NM-KO-200029 Anpep Therapeutic antibody target
Antxr1-KO NM-KO-200030 Antxr1 Therapeutic antibody target
Anxa2-KO NM-KO-191068 Anxa2 Angiogenesis, thrombosis; osteoclast formation, bone resorption
Anxa3-KO NM-KO-190745 Anxa3 Inflammatory Response, aging related.
Anxa5-KO NM-KO-190746 Anxa5 Inflammatory Response, aging related.
Aoah-KO NM-KO-190242 Aoah Immune-related
Aoc3-KO NM-KO-200031 Aoc3 Therapeutic antibody target
Apba1-KO NM-KO-190747 Apba1 Synaptic Formation and Alzheimer's Disease related
Apba3-KO NM-KO-190748 Apba3 Alzheimer's Disease related
Apbb1-KO NM-KO-190749 Apbb1 Beta-amyloid metabolism related;Alzheimer's disease research related
Apbb1ip-KO NM-KO-200032 Apbb1ip Therapeutic antibody target
Apbb2-KO NM-KO-190750 Apbb2 Beta-amyloid metabolism related;Alzheimer's disease research related;Synaptic Formation related.
Apc-(L850X) NM-KI-200001 Apc Heterozygotes of this strain are highly susceptible to spontaneous intestinal adenoma formation. Homozygous mice are not viable.
Apcdd1-KO NM-KO-200033 Apcdd1 Therapeutic antibody target
Apcs-KO NM-KO-190001 Apcs Immune-related
Apln-KO NM-KO-200034 Apln Therapeutic antibody target
Aplnr-DreERT2 NM-KI-00132 Aplnr recombinase tool
Aplp1-KO NM-KO-190751 Aplp1 Beta-amyloid metabolism related;Alzheimer's disease research related
Apoa1-KO NM-KO-190752 Apoa1 Cholesterol Metabolism related
Apoa2-KO NM-KO-200035 Apoa2 Therapeutic antibody target
Apob-(Q1388H) NM-KI-00056 Apob lipid metabolism studies, cardiovascular disease research
Apoc3-KO NM-KO-200036 Apoc3 Therapeutic antibody target
Apoe-KO NM-KO-190565 Apoe Atherosclerosis,hyperlipidemia,hypercholesterolemia,cerebral infarction,AD,chronic hepatitis etc.
APOE2-HU NM-HU-190013 Apoe Immune-related
APOE4-HU NM-HU-190002 Apoe Cardiovascular disease
APOE3-HU NM-HU-190003 Apoe Cardiovascular disease
Apoe-KO NM-KO-00033 Apoe Atherosclerosis,hyperlipidemia,hypercholesterolemia,cerebral infarction,AD,chronic hepatitis etc.
Apoh-KO NM-KO-200037 Apoh Therapeutic antibody target
App-KO NM-KO-190444 App neuronal differentiation/migration, synaptic regulation and Alzheimer's disease related
Appl1-CKO NM-CKO-00118 Appl1
Appl2-CKO NM-CKO-00112 Appl2
Aqp1-KO NM-KO-190915 Aqp1 Aquaporin, eye movement imbalance, urine osmotic pressure
Aqp4-KO NM-KO-190243 Aqp4 Immune-related
Aqp5-KO NM-KO-190244 Aqp5 Immune-related
Ar-CKO NM-CKO-00110 Ar
Areg-KO NM-KO-190002 Areg Immune-related
Arfip2-KO NM-KO-190916 Arfip2 NF-kappaB signaling, regulates aggregation of huntingtin proteins
Arg2-KO NM-KO-190917 Arg2 Nitric oxide and polyamine metabolism
Arhgef5-KO NM-KO-200038 Arhgef5 Therapeutic antibody target
Arih1-KO NM-KO-190245 arih1 Immune-related
Arl6ip6-KO NM-KO-190753 Arl6ip6 Proteostasis，aging related.
Artn-KO NM-KO-200039 Artn Therapeutic antibody target
Asap3-CKO NM-CKO-00038 Asap3
Asgr1-KO NM-KO-190246 Asgr1 Immune-related
Asic1-KO NM-KO-200040 Asic1 Therapeutic antibody target
Aspa-KO NM-KO-191129 Aspa NAA scavenger,Canavan disease,nervous system,auditory
Asph-KO NM-KO-200041 Asph Therapeutic antibody target
Astl-KO NM-KO-200042 Astl Therapeutic antibody target
Atg5-KO NM-KO-18004 Atg5
Atg5-CKO NM-CKO-00131 Atg5 Autophagy, Atg5 function study
Atp2b2-KO NM-KO-190918 Atp2b2 Intracellular calcium homeostasis, hearing, deafness, cerebellar malformation, ear malformation
Atp5b-KO NM-KO-190247 Atp5b Immune-related
Atp6ap2-KO NM-KO-190919 Atp6ap2 Podocyte function, autophagy, nephrotic syndrome
Atp6v1g2-KO NM-KO-191134 Atp6v1g2 Nervous system, synaptic vesicle acidification
Atp7b-(H1071Q) NM-KI-18001 Atp7b
Atpaf1-KO NM-KO-190248 Atpaf1 Immune-related
Atpaf2-KO NM-KO-190249 Atpaf2 Immune-related
Atrn-KO NM-KO-190646 Atrn Cardiovascular diseases
Atxn2-KO NM-KO-190920 Atxn2 Microsatellite augmentation disease, type I diabetes, obesity and hypertension, hepatic steatosis, sports learning related research
Atxn3-KO NM-KO-190921 Atxn3 Nervous system, spinocerebellar ataxia 3, exploratory behavior
AU021092-CKO NM-CKO-00111 AU021092
Avpr1a-KO NM-KO-200043 Avpr1a Therapeutic antibody target
Avpr1b-KO NM-KO-190922 Avpr1b Nervous system, hypothalamic-pituitary-adrenal axis, epilepsy
Axin2-KO NM-KO-190673 Axin2 colorectal cancer
Axl-KO NM-KO-200044 Axl Therapeutic antibody target
B2m-KO(M-NSG) NM-NSG-002 B2m immunodeficiency,immune system,transplantation research
B2m-KO(NOD-scid) NM-KO-18035 B2m immunodeficiency,immune system,transplantation research
B2m-KO NM-KO-18021 B2m immune system
B4galnt1-KO NM-KO-200045 B4galnt1 Therapeutic antibody target
Bace2-KO NM-KO-190754 Bace2 Alzheimer's Disease related
Bad-KO NM-KO-190730 Bad Cell apoptosis
Bak1-KO NM-KO-200046 Bak1 Therapeutic antibody target
Bambi-KO NM-KO-200047 Bambi Therapeutic antibody target
Batf3-KO NM-KO-190447 Batf3 Immune-related, CD8 deficiency
Bbox1-KO NM-KO-190923 Bbox1 Schizophrenia
BC028528-CKO NM-CKO-00012 BC028528
Bcat1-KO NM-KO-190551 Bcat1 hypervalinemia and hyperleucine-isoleucinemia related
Bche-KO NM-KO-190755 Bche Beta-amyloid metabolism related;Alzheimer's disease research related
Bcl2a1c-KO NM-KO-200048 Bcl2a1c Therapeutic antibody target
Bcl3-KO NM-KO-200049 Bcl3 Therapeutic antibody target
Bcl6-KO NM-KO-190756 Bcl6 Allergy and Asthma related.
Bcl6b-KO NM-KO-200050 Bcl6b Therapeutic antibody target
Bcl7a-KO NM-KO-200051 Bcl7a Therapeutic antibody target
Bcl7b-KO NM-KO-200052 Bcl7b Therapeutic antibody target
Bcl7c-KO NM-KO-200053 Bcl7c Therapeutic antibody target
Bcl9-KO NM-KO-200054 Bcl9 Therapeutic antibody target
Bcl9l-KO NM-KO-200055 Bcl9l Therapeutic antibody target
Bcr-KO NM-KO-190629 Bcr leukemia
Bdkrb1-KO NM-KO-190924 Bdkrb1 Pain, inflammatory response
Bdkrb2-KO NM-KO-190925 Bdkrb2 Vasodilation, edema, smooth muscle spasm and painful fiber irritation
Becn1-KO NM-KO-18028 Becn1 autophagy, cancer research
Becn1-CKO NM-CKO-18008 Becn1 cancer research,Autophagy
Bhlhe40-KO NM-KO-191085 Bhlhe40 Immune system,autoimmune disease; control of circadian rhythm,cell differentiation
R26-(BirA) NM-KI-00085 BirA
Birc2-KO NM-KO-190757 Birc2 Stress Responses,Apoptosis related
Blm-KO NM-KO-191081 Blm Anemia, Bloom syndrome, cancer
Bmf-KO NM-KO-190003 Bmf Immune-related
Bmp2-KO NM-KO-190528 Bmp2 Growth Factors
Bmp3-KO NM-KO-190529 Bmp3 Growth Factors ，bone density，osteoblast differentiation
Bmp6-KO NM-KO-190530 Bmp6 Growth Factors， iron homeostasis, fat and bone development, and ovulation.
Bmp7-KO NM-KO-190531 Bmp7 Growth Factors，skeletal、 kidne developmental
Bmpr1b-KO NM-KO-200056 Bmpr1b Therapeutic antibody target
Bnip3-KO NM-KO-191077 Bnip3 Pro-apoptotic factor; cardiovascular system, post-ischemic ventricular remodeling; tumor
Bnip3l-KO NM-KO-191078 Bnip3l Pro-apoptotic factor; blood system, red blood cells; tumor
Bnipl-CKO NM-CKO-00062 Bnipl
Bod1-KO NM-KO-190702 Bod1
Boll-KO NM-KO-190004 Boll Immune-related
Bpifa1-CKO NM-CKO-00074 Bpifa1 Epigenetic regulation of gene expression，nervous system
Braf-(flox-V600E) NM-KI-190053 Braf cancer research
Brca1-CKO NM-CKO-18007 Brca1 cancer research
Brd7-CKO NM-CKO-00034 Brd7
Brs3-KO NM-KO-190608 Brs3 The protein encoded by this gene is a G protein-coupled membrane receptor that binds bombesin-like peptides. This binding results in activation of a phosphatidylinositol-calcium second messenger system, with physiological effects including regulation of metabolic rate, glucose metabolism, and hypertension.
Bst1-KO NM-KO-200057 Bst1 Therapeutic antibody target
Bst2-KO NM-KO-200058 Bst2 Therapeutic antibody target
Btbd10-KO NM-KO-00043 Btbd10
Btk-KO NM-KO-190005 Btk Immune-related
BTLA-HU NM-HU-190040 Btla Immunotherapy,cancer research,drug screening
Btla-KO NM-KO-18051 Btla
Btn1a1-KO NM-KO-200059 Btn1a1 Therapeutic antibody target
Btn2a2-KO NM-KO-200060 Btn2a2 Therapeutic antibody target
Btnl1-KO NM-KO-200061 Btnl1 Therapeutic antibody target
Btnl10-KO NM-KO-200062 Btnl10 Therapeutic antibody target
Btnl2-KO NM-KO-200063 Btnl2 Therapeutic antibody target
Btnl4-KO NM-KO-200064 Btnl4 Therapeutic antibody target
Btnl6-KO NM-KO-200065 Btnl6 Therapeutic antibody target
Btnl9-KO NM-KO-190250 Btnl9 Immune-related
Btrc-KO NM-KO-190695 Btrc phosphorylation-dependent ubiquitination
C1qb-KO NM-KO-190758 C1qb Inflammatory Response, aging related.
C1qc-KO NM-KO-190759 C1qc Inflammatory Response, aging related.
C1ql1-KO NM-KO-200066 C1ql1 Therapeutic antibody target
C1qtnf1-KO NM-KO-191210 C1qtnf1
R26-(LNL-C1qtnf1) NM-KI-190129 C1qtnf1
C1qtnf1-KO NM-KO-190251 C1qtnf1 Immune-related
C1qtnf12-KO NM-KO-200067 C1qtnf12 Therapeutic antibody target
C1qtnf2-KO NM-KO-200068 C1qtnf2 Therapeutic antibody target
C1qtnf3-KO NM-KO-200069 C1qtnf3 Therapeutic antibody target
C1qtnf4-KO NM-KO-200070 C1qtnf4 Therapeutic antibody target
C1qtnf6-KO NM-KO-200071 C1qtnf6 Therapeutic antibody target
C1qtnf7-KO NM-KO-200072 C1qtnf7 Therapeutic antibody target
C1qtnf9-KO NM-KO-200073 C1qtnf9 Therapeutic antibody target
C1s1-KO NM-KO-190760 C1s1 Inflammatory Response, aging related.
C1s2-KO NM-KO-200074 C1s2 Therapeutic antibody target
C2-KO NM-KO-190179 C2 Immune-related
C3-KO NM-KO-191193 C3 Immune-related
C4b-KO NM-KO-190761 C4b Inflammatory Response, aging related.
C5-HU NM-HU-2000013 C5a Immunotherapy,cancer research,drug screening
C5ar1-KO NM-KO-190180 C5ar1 Immune-related
C6-KO NM-KO-200075 C6 Therapeutic antibody target
Cab39-KO NM-KO-191103 Cab39 Cancer, tumorigenesis and development
Cab39l-KO NM-KO-191104 Cab39l Cancer, tumorigenesis and development
Cacna1a-KO NM-KO-200076 Cacna1a Therapeutic antibody target
Cacna1c-KO NM-KO-190926 Cacna1c Endocrine and metabolic systems, insulin secretion, glucose tolerance; nervous system, anxiety, motor coordination
Cacna2d1-KO NM-KO-200077 Cacna2d1 Therapeutic antibody target
Cadm1-KO NM-KO-200078 Cadm1 Therapeutic antibody target
Cadm2-KO NM-KO-200079 Cadm2 Therapeutic antibody target
Cadm4-KO NM-KO-190762 Cadm4
CAG-GFP NM-TG-00005 CAG-GFP Reporter mice,EGFP
Calb1-KO NM-KO-190927 Calb1 Nervous system, neurodegeneration and synaptic transmission, cerebellar Purkinje cells, motor coordination, aging
Calca-KO NM-KO-190928 Calca Calcitonin and calcitonin gene-related peptide-α (CGRP-α), vascular and nervous system related studies, bone mineralization
Calm1-KO NM-KO-190703 Calm1 The encoded protein acts as a calcium sensor and is involved in relaying signals to calcium-sensitive proteins, enzymes and ion channels. The protein-calcium complex binds target proteins to regulate several cellular processes, including smooth muscle contraction, inflammation, apoptosis and the immune response. Mutations in the human gene are associated with catecholaminergic polymorphic ventricular tachycardia and long QT syndrome 14.
Cand1-KO NM-KO-190252 Cand1 Immune-related
Capn1-KO NM-KO-191158 Capn1
Capn3-KO NM-KO-191159 Capn3 Mutations in this gene are associated with limb-girdle muscular dystrophies type 2A.
Capn6-KO NM-KO-191160 Capn6 Calpains have been implicated in neurodegenerative processes
Capza3-KO NM-KO-200080 Capza3 Therapeutic antibody target
Car12-KO NM-KO-200081 Car12 Therapeutic antibody target
Car2-KO NM-KO-190006 Car2 Immune-related
Car6-KO NM-KO-200082 Car6 Therapeutic antibody target
Car9-KO NM-KO-200083 Car9 Therapeutic antibody target
Carm1-CKO NM-CKO-190015 Carm1 Epigenetic
Carmil2-KO NM-KO-200084 Carmil2 Therapeutic antibody target
Cars-KO NM-KO-190253 Cars Immune-related
Cartpt-KO NM-KO-190647 Cartpt obesity
R26-(CAG-LSL-Cas13d-IRES-tdTomato) NM-KI-190063 Cas13d RNA editing,Cas13d
R26-(Cas9) NM-KI-00120 Cas9 gene editing, gene modification
R26-(CAG-LNL-Cas9-IRES-Luciferase-pA)1 NM-KI-18002 Cas9 Cas9,gene editing
R26-(Cas9) NM-KI-00038 Cas9 gene editing, gene modification
Casp1-KO NM-KO-190443 Casp1 Inflammation and cell death
Casp4-KO NM-KO-190763 Casp4 Apoptosis, Alzheimer's Disease related
Casp4-CKO NM-CKO-190061 Casp4 cell pyroptosis, cell apoptosis
Casp7-KO NM-KO-190929 Casp7 Apoptosis, immunity, cancer
Casp8-KO NM-KO-190440 Casp8 cancer research,Apoptosis
Casp8-CKO NM-CKO-190003 Casp8 cancer research,Apoptosis
Cav1-KO NM-KO-190930 Cav1 Tumor suppression,vascular system,fibrosis,Berardinelli-Seip congenital lipodystrophy
Cbl-KO NM-KO-190007 Cbl Immune-related
Cblb-KO NM-KO-190008 Cblb Immune-related
Cblif-KO NM-KO-190089 Cblif Immune-related
Cbx7-CKO NM-CKO-00114 Cbx7
Ccdc103-KO NM-KO-191135 Ccdc103 Primary ciliary dyskinesia
Ccdc3-CKO NM-CKO-00082 Ccdc3 mortality/aging，nervous system
Ccdc42-KO NM-KO-190764 Ccdc42
Cckbr-KO NM-KO-190609 Cckbr This gene encodes a G-protein coupled receptor for gastrin and cholecystokinin (CCK), regulatory peptides of the brain and gastrointestinal tract. This protein is a type B gastrin receptor, which has a high affinity for both sulfated and nonsulfated CCK analogs and is found principally in the central nervous system and the gastrointestinal tract. A misspliced transcript variant including an intron has been observed in cells from colorectal and pancreatic tumors.
Ccl1-KO NM-KO-190009 Ccl1 Immune-related
Ccl11-KO NM-KO-191181 Ccl11 This eosinophil-specific chemokine is thought to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections.
Ccl11-KO NM-KO-190519 Ccl11 Involved in immunoregulatory and inflammatory processes.This eosinophil-specific chemokine is thought to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections.
Ccl12-KO NM-KO-190765 Ccl12 may contribute to tumor-associated leukocyte infiltration and to the antiviral state against HIV infection.
Ccl17-KO NM-KO-190010 Ccl17 Immune-related
Ccl19-KO NM-KO-190011 Ccl19 Immune-related
Ccl20-KO NM-KO-190012 Ccl20 Immune-related
Ccl22-KO NM-KO-190013 Ccl22 Immune-related
Ccl24-KO NM-KO-190520 Ccl24 This gene belongs to the subfamily of small cytokine CC genes.Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes.
Ccl25-KO NM-KO-190015 Ccl25 Immune-related
Ccl28-KO NM-KO-00166 Ccl28
Ccl3-KO NM-KO-190014 Ccl3 Immune-related
Ccl4-KO NM-KO-190016 Ccl4 Immune-related
Ccl5-KO NM-KO-190017 Ccl5 Immune-related
Ccl7-KO NM-KO-190766 Ccl7 This gene encodes monocyte chemotactic protein 3, a secreted chemokine which attracts macrophages during inflammation and metastasis.
Ccl8-KO NM-KO-191182 Ccl8 may contribute to tumor-associated leukocyte infiltration and to the antiviral state against HIV infection.
Ccl8-KO NM-KO-190521 Ccl8 Chemokines
Ccna2-KO NM-KO-200085 Ccna2 Therapeutic antibody target
Ccnd1-KO NM-KO-190767 Ccnd1 Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.
Ccnd3-KO NM-KO-190726 Ccnd3 cell cycle related
Ccne1-KO NM-KO-190931 Ccne1 Cell cycle, tumor
Ccne2-KO NM-KO-190932 Ccne2 Cell cycle, tumor, male fertility
Ccng2-KO NM-KO-191082 Ccng2 Cell cycle; cancer, ovarian cancer, stomach cancer
Ccny-CKO NM-CKO-00071 Ccny
CCR1-HU NM-HU-190067 Ccr1 Immunotherapy,cancer research,drug screening
Ccr1-KO NM-KO-190768 Ccr1 Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite.
Ccr10-KO NM-KO-190019 Ccr10 Immune-related
Ccr2-(2A-DreERT2) NM-KI-200023 Ccr2 Dre recombinase tool
Ccr2-KO NM-KO-190018 Ccr2 Immune-related
CCR2-HU NM-HU-18026 Ccr2 Immunotherapy,Cancer research,Drug screening
Ccr3-KO NM-KO-190020 Ccr3 Immune-related
Ccr4-KO NM-KO-191195 Ccr4 Immune-related
Ccr5-KO NM-KO-190021 Ccr5 Immune-related
Ccr6-KO NM-KO-190022 Ccr6 Immune-related
Ccr7-KO NM-KO-190023 Ccr7 Immune-related
Ccr8-KO NM-KO-190024 Ccr8 Immune-related
Ccr9-KO NM-KO-190025 Ccr9 Immune-related
Ccsap-KO NM-KO-200086 Ccsap Therapeutic antibody target
Cct4-KO NM-KO-190254 Cct4 Immune-related
Cd109-KO NM-KO-200087 Cd109 Therapeutic antibody target
Cd14-KO NM-KO-190026 Cd14 Immune-related
Cd151-KO NM-KO-200088 Cd151 Therapeutic antibody target
Cd160-KO NM-KO-200089 Cd160 Therapeutic antibody target
CD160-HU NM-HU-190057 Cd160 Immunotherapy,cancer research,drug screening
Cd163-KO NM-KO-190027 Cd163 Immune-related
Cd19-(IRES-DTREGFP） NM-KI-190042 Cd19 DTR mouse
CD19&CD3E-HU NM-HU-190027 Cd19，Cd3e Immune-related
CD19-KO NM-KO-18001 Cd19
CD19-HU NM-HU-00110 Cd19 Immunotherapy,cancer research,drug screening
Cd1d1-KO NM-KO-190769 Cd1d1 This gene encodes a divergent member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin.
Cd1d2-KO NM-KO-190770 Cd1d2 This gene encodes a divergent member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin.
Cd2-KO NM-KO-191183 Cd2 The protein encoded by this gene is a surface antigen found on all peripheral blood T-cells. The encoded protein interacts with LFA3 (CD58) on antigen presenting cells to optimize immune recognition.
Cd2-KO NM-KO-190028 Cd2 Immune-related
Cd2-(2A-CreERT2-WPRE-pA) NM-KI-18017 Cd2 Cre recombinase tool
Cd200-KO NM-KO-190029 Cd200 Immune-related
Cd200r2-KO NM-KO-200090 Cd200r2 Therapeutic antibody target
Cd200r4-KO NM-KO-200091 Cd200r4 Therapeutic antibody target
Cd207-(2A-CreERT2) NM-KI-200021 Cd207 Cre recombinase tool
Cd207-KO NM-KO-190030 Cd207 Immune-related
Cd209a-KO NM-KO-190255 Cd209a Immune-related
CD22-HU NM-HU-2000014 Cd22 Immunotherapy,cancer research,drug screening
Cd22-KO NM-KO-200092 Cd22 Therapeutic antibody target
Cd244a-KO NM-KO-190032 Cd244a Immune-related
Cd247-KO NM-KO-200093 Cd247 Therapeutic antibody target
Cd248-KO NM-KO-200094 Cd248 Therapeutic antibody target
Cd24a-KO NM-KO-190031 Cd24a Immune-related
CD27-HU NM-HU-190035 Cd27 Immunotherapy,cancer research,drug screening
Cd27-KO NM-KO-190033 Cd27 Immune-related
PD-L1-HU NM-HU-190039 Cd274 Immunotherapy,cancer research,drug screening
PD-L1&SEMA4D-HU NM-HU-190034 Cd274，Sema4d Immunotherapy,cancer research,drug screening
PD-L1&GITR-HU NM-HU-190015 Cd274，Tnfrsf18 Immune-related
PD-L1&CD40-HU NM-HU-18024 Cd274，Cd40 Immunotherapy,cancer research,drug screening
Cd274-KO NM-KO-18044 Cd274 inflammatory,immune system
PD-L1&LAG3-HU NM-HU-00137 Cd274，Lag3 Immunotherapy,cancer research,drug screening
PD-L1&TIGIT-HU NM-HU-18013 Cd274，Tigit Immunotherapy,cancer research,drug screening
PD-L1&OX40-HU NM-HU-00111 Cd274，Tnfrsf4 cancer research,Immunotherapy,drug screening
PD-L1-HU NM-HU-00062 Cd274 Immunotherapy,cancer research,drug screening
PD-L1&TIM3-HU NM-HU-190056 Cd274, Havcr2 Immunotherapy,cancer research,drug screening
Cd276-KO NM-KO-18039 Cd276 inflammation,autoimmunity
Cd28-KO NM-KO-191199 Cd28 Immune-related
CD28-HU NM-HU-190011 Cd28 Immune-related
Cd28-KO NM-KO-190034 Cd28 Immune-related
Cd300a-KO NM-KO-200095 Cd300a Therapeutic antibody target
Cd300lf-KO NM-KO-200096 Cd300lf Therapeutic antibody target
Cd320-KO NM-KO-200097 Cd320 Therapeutic antibody target
Cd33-CKO NM-CKO-200002 Cd33 Therapeutic antibody target
Cd33-KO NM-KO-200578 Cd33 Therapeutic antibody target. Immune-related
CD33-HU NM-HU-200002 Cd33 Immunotherapy,cancer research,drug screening
Cd33-KO NM-KO-200098 Cd33 Therapeutic antibody target
Cd34-KO NM-KO-190035 Cd34 Immune-related
Cd36-KO NM-KO-190771 Cd36 this protein may have important functions as a cell adhesion molecule,Mutations in this gene cause platelet glycoprotein deficiency.
CD36-HU NM-HU-00112 Cd36 Immunotherapy,cancer research,drug screening
Cd37-KO NM-KO-200099 Cd37 Therapeutic antibody target
Cd38-KO NM-KO-190036 Cd38 Immune-related
Cd3d-KO NM-KO-190719 Cd3d Immune related
Cd3e-KO NM-KO-190727 Cd3e Immune related
CD3E-HU NM-HU-00114 Cd3e Immunotherapy,cancer research,drug screening
Cd3g-KO NM-KO-190720 Cd3g Immune related
Cd4-(IRES-DTREGFP) NM-KI-190121 Cd4 DTR mouse
Cd4-KO NM-KO-190441 Cd4 immune system, immunodeficiency
Cd4-(2A-DreERT2） NM-KI-190030 Cd4 Dre recombinase tool
Cd4-KO NM-KO-18023 Cd4 immune system, immunodeficiency
CD4-HU NM-HU-00115 Cd4 Immunotherapy,cancer research,drug screening
Cd40-KO NM-KO-190038 Cd40 Immune-related
CD40-HU NM-HU-00076 Cd40 cancer research,Immunotherapy,drug screening
Cd40lg-KO NM-KO-190540 Cd40lg TNF Receptor Superfamily Members,Allergy and Asthma
Cd44-KO NM-KO-190039 Cd44 Immune-related
R26-(SA-CD46-IRES-tdTomato) NM-KI-190087 CD46 Immune-related
Cd46-KO NM-KO-190040 Cd46 Immune-related
Cd47-KO NM-KO-190041 Cd47 Immune-related
CD47-HU NM-HU-00050 Cd47 Immunotherapy,cancer research,drug screening
Cd48-KO NM-KO-190734 Cd48 Immune related
Cd5-KO NM-KO-190042 Cd5 Immune-related
Cd52-KO NM-KO-200100 Cd52 Therapeutic antibody target
Cd55-KO NM-KO-200101 Cd55 Therapeutic antibody target
Cd59a-KO NM-KO-200102 Cd59a Therapeutic antibody target
Cd59b-KO NM-KO-200103 Cd59b Therapeutic antibody target
Cd5l-KO NM-KO-191204 Cd5l Immune-related
Cd6-KO NM-KO-190043 Cd6 Immune-related
Cd63-KO NM-KO-190044 Cd63 Immune-related
Cd68-KO NM-KO-190045 Cd68 Immune-related
Cd69-KO NM-KO-190046 Cd69 Immune-related
Cd7-KO NM-KO-190047 Cd7 Immune-related
Cd70-KO NM-KO-190048 Cd70 Immune-related
Cd74-KO NM-KO-190772 Cd74 The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response.
Cd79a-KO NM-KO-191179 Cd79a Immune related
Cd79a-KO NM-KO-190049 Cd79a Immune-related
CD79B-HU NM-HU-2000012 Cd79b Immunotherapy,cancer research,drug screening
Cd79b-KO NM-KO-200104 Cd79b Therapeutic antibody target
Cd80-KO NM-KO-190184 Cd80 Immune-related
CD80-HU NM-HU-00074 Cd80 cancer research,immune system
Cd81-KO NM-KO-190733 Cd81 Immune related
CD81-HU NM-HU-190041 Cd81 Immunotherapy,cancer research,drug screening
Cd82-KO NM-KO-200105 Cd82 Therapeutic antibody target
Cd83-KO NM-KO-190051 Cd83 Immune-related
Cd84-KO NM-KO-200106 Cd84 Therapeutic antibody target
Cd86-KO NM-KO-18041 Cd86 immune system
CD86-HU NM-HU-00045 Cd86 Immunotherapy,cancer research,drug screening
Cd8a-(IRES-DTREGFP） NM-KI-190045 Cd8a DTR mouse
Cd8a-KO NM-KO-190181 Cd8a Immune-related
Cd8a-(V5-IRES-luci-2A-EGFP) NM-KI-18030 Cd8a gene tracing
Cd8b1-KO NM-KO-190183 Cd8b1 Immune-related
Cd9-KO NM-KO-191125 Cd9 Cancer, reproductive system, female infertility
Cdc27-KO NM-KO-190933 Cdc27 Cell cycle, mitosis
Cdcp1-KO NM-KO-200107 Cdcp1 Therapeutic antibody target
Cdh1-(2A-DreERT2） NM-KI-190031 Cdh1 Dre recombinase tool
Cdh1-CKO NM-CKO-18016 Cdh1
Cdh11-KO NM-KO-200108 Cdh11 Therapeutic antibody target
Cdh17-KO NM-KO-200109 Cdh17 Therapeutic antibody target
Cdh3-KO NM-KO-200110 Cdh3 Therapeutic antibody target
Cdh6-KO NM-KO-200111 Cdh6 Therapeutic antibody target
Cdh8-KO NM-KO-190934 Cdh8 Nervous system, CNS synaptic transmission
Cdk12-CKO NM-CKO-190059 Cdk12 Cancer
Cdk2-KO NM-KO-190052 Cdk2 Immune-related
Cdk4-KO NM-KO-190614 Cdk4 The protein encoded by this gene is a member of the Ser/Thr protein kinase family.It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb).
Cdk5r1-KO NM-KO-190256 Cdk5r1 Immune-related
Cdk5rap2-CKO NM-CKO-00055 Cdk5rap2 Hertwig's anemia.
Cdk9-KO NM-KO-190053 Cdk9 Immune-related
Cdkl1-KO NM-KO-190773 Cdkl1 Cell Cycle
Cdkn1a-KO NM-KO-190774 Cdkn1a Mice that lack this gene have the ability to regenerate damaged or missing tissue.
Cdkn2a-KO NM-KO-190633 Cdkn2a cancer
Cdkn2a-(Luc-tdTomato-CreERT2) NM-KI-18039 Cdkn2a
Cdkn2b-KO NM-KO-190621 Cdkn2b This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression.
Cdkn3-KO NM-KO-190622 Cdkn3 The protein encoded by this gene belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Ceacam1-KO NM-KO-190054 Ceacam1 Immune-related
Ceacam2-KO NM-KO-200112 Ceacam2 Therapeutic antibody target
Ceacam5-KO NM-KO-200113 Ceacam5 Therapeutic antibody target
Cela1-(2A-DreERT2) NM-KI-190094 Cela1 Dre recombinase tool, pancreatic acinar cells
Cenpi-KO NM-KO-200114 Cenpi Therapeutic antibody target
Cenpx-KO NM-KO-191189 Cenpx Epigenetic
Cenpx-CKO NM-CKO-190056 Cenpx Epigenetic
Cept1-KO NM-KO-200115 Cept1 Therapeutic antibody target
Cers2-CKO NM-CKO-00052 Cers2
Cfd-KO NM-KO-200116 Cfd Therapeutic antibody target
Cfhr1-KO NM-KO-190775 Cfhr1 Mutations in this gene are associated with an increased risk of atypical hemolytic-uremic syndrome.
Cfi-KO NM-KO-200117 Cfi Therapeutic antibody target
Cfp-KO NM-KO-200118 Cfp Therapeutic antibody target
Cga-KO NM-KO-200119 Cga Therapeutic antibody target
Cgn-KO NM-KO-190055 Cgn Immune-related
Chd3-CKO NM-CKO-00037 Chd3
Chek1-KO NM-KO-190561 Chek1 cancer research
Chgb-KO NM-KO-190935 Chgb Adrenal chromaffin cell function, catecholamine secretion, Parkinson's disease
Chia1-KO NM-KO-190776 Chia1 The variations in this gene can lead to asthma susceptibility.
Chid1-KO NM-KO-00029 Chid1 immune system,metabolism
Chil1-KO NM-KO-190777 Chil1  The protein is thought to play a role in the process of inflammation and tissue remodeling.
Chrdl1-KO NM-KO-200120 Chrdl1 Therapeutic antibody target
Chrm1-KO NM-KO-191175 Chrm1 The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract.
Chrm4-KO NM-KO-191176 Chrm4 G protein-coupled receptors
Chrm5-KO NM-KO-191177 Chrm5 G protein-coupled receptors，mouse studies link its function to adenylyl cyclase inhibition.
Chrna2-KO NM-KO-200121 Chrna2 Therapeutic antibody target
Chrna4-KO NM-KO-190567 Chrna4 Mutations in this gene cause nocturnal frontal lobe epilepsy type 1.
Chrna5-KO NM-KO-190568 Chrna5 Defects in this gene have been linked to susceptibility to lung cancer type 2 (LNCR2).
Chrna6-KO NM-KO-190569 Chrna6 Single nucleotide polymorphisms in this gene have been associated with both nicotine and alcohol dependence.
Chrna7-Fan1-KO NM-KO-18062 Chrna7，Fan1
Chrnb1-KO NM-KO-190936 Chrnb1 Nervous system, slow channel congenital muscle weakness syndrome
Chsy1-KO NM-KO-190704 Chsy1 Involved in many biological processes including cell proliferation and morphogenesis.
Ciita-KO NM-KO-191207 Ciita Immune-related
Ciita-KO NM-KO-190056 Ciita Immune-related
Cirbp-KO NM-KO-190257 Cirbp Immune-related
Ckap2-KO NM-KO-200122 Ckap2 Therapeutic antibody target
Ckap4-KO NM-KO-200123 Ckap4 Therapeutic antibody target
Clca3a1-KO NM-KO-190778 Clca3a1
Clca3a2-KO NM-KO-190779 Clca3a2
Clca3b-KO NM-KO-190780 Clca3b
Cldn18-KO NM-KO-200124 Cldn18 Therapeutic antibody target
Cldn2-KO NM-KO-200125 Cldn2 Therapeutic antibody target
Cldn3-KO NM-KO-200126 Cldn3 Therapeutic antibody target
Cldn6-KO NM-KO-200127 Cldn6 Therapeutic antibody target
Clec10a-KO NM-KO-190221 Clec10a Immune-related
Clec12a-KO NM-KO-190222 Clec12a Immune-related
Clec12b-KO NM-KO-190223 Clec12b Immune-related
Clec14a-KO NM-KO-200128 Clec14a Therapeutic antibody target
Clec18a-CKO NM-CKO-00006 Clec18a
Clec1b-KO NM-KO-190229 Clec1b Immune-related
Clec2d-KO NM-KO-200129 Clec2d Therapeutic antibody target
Clec3b-KO NM-KO-00169 Clec3b
Clec4a2-KO NM-KO-190214 Clec4a2 Immune-related
Clec4b1-KO NM-KO-200130 Clec4b1 Therapeutic antibody target
Clec4b2-KO NM-KO-190781 Clec4b2 cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response
Clec4e-KO NM-KO-190215 Clec4e Immune-related
Clec4n-KO NM-KO-190217 Clec4n Immune-related
Clec5a-KO NM-KO-190205 Clec5a Immune-related
Clec7a-KO NM-KO-190219 Clec7a Immune-related
Clec9a-(2A-CreERT2) NM-KI-200022 Clec9a Cre recombinase tool
Clec9a-KO NM-KO-190204 Clec9a Immune-related
Clic1-KO NM-KO-190937 Clic1 Platelet, coagulation
Clic4-KO NM-KO-190938 Clic4 Female fertility, immune system, angiogenesis
Clic5-KO NM-KO-190939 Clic5 Ciliated cell lesions, cataracts, glomerular defects, fat and energy metabolism
Clint1-KO NM-KO-200131 Clint1 Therapeutic antibody target
Clptm1-KO NM-KO-200132 Clptm1 Therapeutic antibody target
Clta-KO NM-KO-190057 Clta Immune-related
Cltc-KO NM-KO-190940 Cltc Intracellular transport and endocytosis
Clu-(2A-DreERT2) NM-KI-200025 Clu Dre recombinase tool
Clu-KO NM-KO-190782 Clu Tumor progression，neurodegenerative disorders
Cma1-KO NM-KO-190783 Cma1 Hematopoietic, immune
Cmklr1-KO NM-KO-200133 Cmklr1 Therapeutic antibody target
CMV-GFP NM-TG-00006 CMV-GFP Reporter mice,EGFP
Cnga1-KO NM-KO-190941 Cnga1 Phototransduction, autosomal recessive inheritance (ARRP) disease of retinitis pigmentosa
Cnga3-KO NM-KO-190942 Cnga3 Visual, cones, color blindness (rod monochromatic) and color blindness, smell
Cnga4-KO NM-KO-190943 Cnga4 Olfactory, odor adaptation
Cngb3-KO NM-KO-190944 Cngb3 Vision, cones, color blindness 3, progressive cone dystrophy and juvenile macular degeneration (also known as Stargardt disease)
Cnr1-KO NM-KO-190945 Cnr1 Nervous system, behavior, depression, epilepsy
Cnst-KO NM-KO-200134 Cnst Therapeutic antibody target
Cntn2-KO NM-KO-200135 Cntn2 Therapeutic antibody target
Col10a1-KO NM-KO-190258 Col10a1 Immune-related
Col26a1-KO NM-KO-200136 Col26a1 Therapeutic antibody target
Col2a1-(2A-CreERT2) NM-KI-18029 Col2a1 Cre recombinase tool
Col5a3-KO NM-KO-200137 Col5a3 Therapeutic antibody target
Col6a1-KO NM-KO-200138 Col6a1 Therapeutic antibody target
Commd4-KO NM-KO-191136 Commd4
Cop1-KO NM-KO-190058 Cop1 Immune-related
Coq10a-KO NM-KO-200139 Coq10a Therapeutic antibody target
Cort-KO NM-KO-190059 Cort Immune-related
Cpa3-(CreERT2) NM-KI-200005 Cpa3 Cre recombinase tool
Cpa3-KO NM-KO-190784 Cpa3 Hematopoietic, immune
Cpd-KO NM-KO-190670 Cpd Wnt signaling pathway
Cpe-KO NM-KO-190671 Cpe type 2 diabetes
Cpm-KO NM-KO-190060 Cpm Immune-related
Cpt1a-CKO NM-CKO-00056 Cpt1a Circadian Clock,Fatty acid metabolism,Carnitine Palmitoyltransferase IA Deficiency
Cptp-KO NM-KO-190061 Cptp Immune-related
Cr2-KO NM-KO-190185 Cr2 Immune-related
Crabp1-M2rtTA NM-KI-190118 Crabp1 Tool Mice
Crb1-KO NM-KO-190946 Crb1 Visual, retinopathy, photoreceptor cell development
Creb1-KO NM-KO-190947 Creb1 Nervous system, circadian rhythm, long-term memory, fear, sensory neurons, etc.
Crebbp-CKO NM-CKO-190016 Crebbp Epigenetic
Crem-KO NM-KO-190062 Crem Immune-related
Crlf2-KO NM-KO-190785 Crlf2 Hematopoietic, immune
CSF1-HU NM-HU-190043 Csf1 Immunotherapy,cancer research,drug screening
Csf1-KO NM-KO-190063 Csf1 Immune-related
CSF1R-HU NM-HU-190074 Csf1r Immunotherapy,Cancer research,Drug screening
Csf1r-KO NM-KO-190786 Csf1r Hodgkin lymphoma
Csf1r-(IRES-iCre) NM-KI-190026 Csf1r Cre recombinase tool
Csf2-KO NM-KO-190532 Csf2 Growth Factors，NF-KB pathway，Allergy and Asthma，
CSF2-HU NM-HU-190046 Csf2 Immunotherapy,cancer research,drug screening
Csf2ra-KO NM-KO-200140 Csf2ra Therapeutic antibody target
Csf2rb-KO NM-KO-190787 Csf2rb Respiratory system
Csf3-KO NM-KO-190533 Csf3 Growth Factors，NF-KB pathway，Allergy and Asthma，
Csf3r-KO NM-KO-190788 Csf3r Congenital neutropenia
Csnk1e-KO NM-KO-190948 Csnk1e Nervous system, circadian rhythm
Cspg4-KO NM-KO-200141 Cspg4 Therapeutic antibody target
Cspg4-(2A-DreERT2） NM-KI-190038 Cspg4 Dre recombinase tool
Cspg5-KO NM-KO-200142 Cspg5 Therapeutic antibody target
Ctcfl-KO NM-KO-190259 Ctcfl Immune-related
Ctf1-KO NM-KO-190546 Ctf1
Cth-(Luc) NM-KI-00004 Cth homeostasis,liver，renal function related research and Cystathioninuria study
CTLA4-HU NM-HU-190078 CTLA4 Immunotherapy,cancer research,drug screening
CTLA4-HU NM-HU-190038 Ctla4 Immunotherapy,cancer research,drug screening
CTLA4-HU NM-HU-00014 Ctla4 cancer research,Immunotherapy,drug screening；
PD-L1&CTLA4-HU NM-HU-00102 Ctla4，Cd274 Immunotherapy,cancer research,drug screening
Ctnnal1-(2A-Cre) NM-KI-200016 Ctnnal1 Cre tool mouse
Ctnnb1-KO NM-KO-190634 Ctnnb1 colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer
Ctsc-KO NM-KO-190789 Ctsc Papillon-Lefevre syndrome
Ctsk-(2A-Cre) NM-KI-190019 Ctsk Cre recombinase tool
Ctss-KO NM-KO-200143 Ctss Therapeutic antibody target
Cul2-KO NM-KO-190949 Cul2
Cuzd1-KO NM-KO-200144 Cuzd1 Therapeutic antibody target
Cx3cl1-KO NM-KO-190064 Cx3cl1 Immune-related
Cx3cr1-KO NM-KO-190065 Cx3cr1 Immune-related
Cxcl10-KO NM-KO-190066 Cxcl10 Immune-related
Cxcl11-KO NM-KO-190522 Cxcl11 Chemokines
Cxcl12-KO NM-KO-190523 Cxcl12 Cytokines， embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth and metastasis.
Cxcl13-KO NM-KO-190067 Cxcl13 Immune-related
Cxcl16-KO NM-KO-190524 Cxcl16 Chemokines
Cxcl5-KO NM-KO-190525 Cxcl5 Chemokines， lung inflammation
Cxcl9-KO NM-KO-190069 Cxcl9 Immune-related
Cxcr1-KO NM-KO-190068 Cxcr1 Immune-related
Cxcr2-KO NM-KO-190070 Cxcr2 Immune-related
CXCR2-HU NM-HU-18025 Cxcr2 Immunotherapy,Cancer research,Drug screening
Cxcr3-KO NM-KO-190071 Cxcr3 Immune-related
Cxcr4-KO NM-KO-190072 Cxcr4 Immune-related
Cxcr5-KO NM-KO-191180 Cxcr5 Immune related
Cxcr5-KO NM-KO-190073 Cxcr5 Immune-related
Cyb5d2-KO NM-KO-200145 Cyb5d2 Therapeutic antibody target
Cyba-KO NM-KO-191171 Cyba Mutations in this gene are associated with autosomal recessive chronic granulomatous disease (CGD)
Cybb-KO NM-KO-18031 Cybb CGD, inflammatory
Cyp1a1-Cyp1a2-KO NM-KO-18018 Cyp1a1，Cyp1a2
Cyp2c cluster-KO NM-KO-18019 Cyp2c cluster drug development
R26-(Liver-CYP3A4) NM-KI-18032 CYP3A4 metabolism
R26-(Gut-CYP3A4) NM-KI-18033 CYP3A4 metabolism
Cyp3a-KO NM-KO-190427 Cyp3a57
Cyp3a-KO NM-KO-18056 Cyp3a57
Cyp4a10-KO NM-KO-200146 Cyp4a10 Therapeutic antibody target
Cysltr1-KO NM-KO-190790 Cysltr1 Asthma，cancer
Dab2ip-KO NM-KO-200147 Dab2ip Therapeutic antibody target
Dag1-KO NM-KO-200148 Dag1 Therapeutic antibody target
R26-(CAG-LSL-Avi-dCas9-IRES-EGFP) NM-KI-18031 dCas9
R26-(CAG-LSL-dCas9-VPR-IRES-EGFP-WPRE-pA) NM-KI-18004 dCas9 gene regulation tool,CRISPRa
R26-e(CAG-LSL-KRAB-dCas9-IRES-EGFP) NM-KI-18007 dCas9 CRISPRi,gene regulation tool
CAG-LSL-dCas9-SPH NM-TG-00025 dCas9 gene regulation tool,CRISPRa
Col1a1-(TRE3G-dCas9-VPR-eGFP-pA) NM-KI-00123 dCas9 gene regulation tool,CRISPRa
Dclk1-KO NM-KO-200149 Dclk1 Therapeutic antibody target
Dcstamp-KO NM-KO-200150 Dcstamp Therapeutic antibody target
Dct-KO NM-KO-190074 Dct Immune-related
R26-(ddCas9) NM-KI-00063 ddCas9 gene editing, gene modification
H11-(ddCre) NM-KI-00086 ddCre
Ddit4-KO NM-KO-191072 Ddit4 Vision, retina; disc degeneration (IDD); cancer
Ddit4l-KO NM-KO-191105 Ddit4l Autophagy, nervous system, muscle energy metabolism
Ddr1-KO NM-KO-200151 Ddr1 Therapeutic antibody target
Ddr2-KO NM-KO-200152 Ddr2 Therapeutic antibody target
Ddx4-KO NM-KO-200153 Ddx4 Therapeutic antibody target
Ddx58-KO NM-KO-18063 Ddx58
Defb1-KO NM-KO-191137 Defb1 Defensin, cystic fibrosis, immune system
Degs2-KO NM-KO-200154 Degs2 Therapeutic antibody target
Dennd1a-KO NM-KO-200155 Dennd1a Therapeutic antibody target
Dennd3-KO NM-KO-190260 Dennd3 Immune-related
Dennd4a-KO NM-KO-191138 Dennd4a may be involved in regulating the v-myc avian myelocytomatosis viral (MYC) oncogene.
Deptor-KO NM-KO-191106 Deptor Metabolism,cancer,immunity
Des-KO NM-KO-190261 Des Immune-related
Dexi-KO NM-KO-190262 Dexi Immune-related
Dgcr2-Hira-KO NM-KO-18060 Dgcr2，Hira behavior, cardiovascular, mortality/aging, nervous system
Dgka-KO NM-KO-190714 Dgka Immune related, T cell development related.
Dgkz-KO NM-KO-190715 Dgkz They may be useful for studying the role of diacylglycerol in T cell development and function.
Dhh-KO NM-KO-200156 Dhh Therapeutic antibody target
Dhodh-KO NM-KO-190263 Dhodh Immune-related
Dhrs13-KO NM-KO-200157 Dhrs13 Therapeutic antibody target
Dhtkd1-(Y485X) NM-KI-00005 Dhtkd1
Diaph2-KO NM-KO-190950 Diaph2 Heart development, brain development
Dkk2-KO NM-KO-200158 Dkk2 Therapeutic antibody target
Dkk3-KO NM-KO-190674 Dkk3 Cancer-related genes
Dlg4-KO NM-KO-190951 Dlg4 Nervous system, pain, space learning, depression
Dmd-KO NM-KO-200573 Dmd Duchenne muscular dystrophy research
Dmd-（c.C2983T） NM-KI-18026 Dmd
Dnmt1-CKO NM-CKO-190046 Dnmt1 Epigenetic
Dnmt3a-CKO NM-CKO-190047 Dnmt3a Epigenetic
Dnmt3b-CKO NM-CKO-190017 Dnmt3b Epigenetic
Dnmt3l-CKO NM-CKO-190018 Dnmt3l Epigenetic
Dock6-KO NM-KO-190264 Dock6 Immune-related
Dpep3-KO NM-KO-200159 Dpep3 Therapeutic antibody target
Dpp4-KO NM-KO-190791 Dpp4 Endocrine
DPP4-HU NM-HU-190042 Dpp4 Immunotherapy,cancer research,drug screening
Dpp8-CKO NM-CKO-00047 Dpp8
Dppa3-(Cre) NM-KI-00040 Dppa3 Cre recombinase tool
Dpysl4-KO NM-KO-191139 Dpysl4
Dr1-KO NM-KO-190075 Dr1 Immune-related
Drd1-(2A-CreERT2-WPRE-pA) NM-KI-18016 Drd1 Cre recombinase tool
Drd2-KO NM-KO-190265 Drd2 Immune-related
Drd3-KO NM-KO-190952 Drd3 Nervous system,hereditary primary tremor 1
CAG-Dre NM-TG-00026 Dre Dre recombinase tool
Dsc2-KO NM-KO-200160 Dsc2 Therapeutic antibody target
Dsg1a-KO NM-KO-200161 Dsg1a Therapeutic antibody target
Dsg3-KO NM-KO-200162 Dsg3 Therapeutic antibody target
R26-(CAG-LSL-RSR-tdTomato-2A-DTR) NM-KI-190086 DTR Dre and Dre reporter
Dtx1-KO NM-KO-190077 Dtx1 Immune-related
R26-(Dusp12) NM-KI-18038 Dusp12
Dusp12-KO NM-KO-18054 Dusp12
Dusp2-KO NM-KO-200163 Dusp2 Therapeutic antibody target
Dusp4-KO NM-KO-190792 Dusp4 hematopoietic, immune
Dvl1-KO NM-KO-190675 Dvl1 Cancer-related genes
Dydc1-KO NM-KO-200164 Dydc1 Therapeutic antibody target
Dyrk4-KO NM-KO-190266 Dyrk4 Immune-related
Dzank1-KO NM-KO-200165 Dzank1 Therapeutic antibody target
E2f1-KO NM-KO-190623 E2f1 The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.
E330021D16Rik-KO NM-KO-190267 E330021D16Rik Immune-related
Eapp-KO NM-KO-190560 Eapp Transcription and proliferation.
Ebf1-CKO NM-CKO-00065 Ebf1 not clear
Ebi3-KO NM-KO-190076 Ebi3 Immune-related
Ecscr-KO NM-KO-200166 Ecscr Therapeutic antibody target
Eda-KO NM-KO-200167 Eda Therapeutic antibody target
Eda2r-KO NM-KO-191162 Eda2r The protein encoded by this gene is a type III transmembrane protein of the TNFR (tumor necrosis factor receptor) superfamily
Edar-KO NM-KO-200168 Edar Therapeutic antibody target
Edc4-KO NM-KO-191130 Edc4 Pro-mRNA degradation
Eed-CKO NM-CKO-190019 Eed Epigenetic
Efna4-KO NM-KO-200169 Efna4 Therapeutic antibody target
Egf-KO NM-KO-190630 Egf certain cancers
Egfl6-KO NM-KO-200170 Egfl6 Therapeutic antibody target
H11-(EGFP) NM-KI-00066 EGFP gene tracing,Reporter mice, EGFP
R26-(CAG-LSL-EGFR(T790M) -IRES-Luciferase-2A-tdTomato) NM-KI-190070 EGFR cancer research
R26-(CAG-LSL-EGFR-IRES-luciferase-2A-tdTomato) NM-KI-190066 EGFR cancer research
R26-(CAG-LSL-EGFR (L858R-T790M-C797S)-IRES-luciferase-2A-tdTomato) NM-KI-190067 EGFR cancer research
R26-(CAG-LSL-EGFR (L858R-T790M)-IRES-luciferase-2A-tdTomato) NM-KI-190068 EGFR cancer research
R26-(CAG-LSL-EGFR(L858R)-IRES-Luciferase-2A-tdTomato) NM-KI-190069 EGFR cancer research
Egfr-KO NM-KO-190268 Egfr Immune-related
Egfr-CKO NM-CKO-00133 Egfr cancer research, EGFR fuction study
Egln2-KO NM-KO-191064 Egln2 Hypoxia-inducible factor-related protein,tumor,breast cancer
Ehd4-KO NM-KO-190269 Ehd4 Immune-related
Ehmt1-CKO NM-CKO-190020 Ehmt1 Epigenetic
Ehmt2-CKO NM-CKO-190048 Ehmt2 Epigenetic
Eif4b-KO NM-KO-191114 Eif4b cancer
Eif4e-KO NM-KO-191115 Eif4e Tumor, proto-oncogene
Eif4ebp1-KO NM-KO-191088 Eif4ebp1 Tumor development,tumor hypoxia; metabolism
Eif4ebp2-KO NM-KO-191121 Eif4ebp2 Cell proliferation and differentiation, viral infection, nervous system, synaptic transmission, autism, muscle homeostasis
Eif5b-KO NM-KO-191140 Eif5b
Elf1-KO NM-KO-190270 Elf1 Immune-related
Elk1-KO NM-KO-190615 Elk1 This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene.
Elmo1-KO NM-KO-190953 Elmo1 Male germ cells support cell phagocytosis
Eloa-CKO NM-CKO-190070 Eloa
Emb-KO NM-KO-200171 Emb Therapeutic antibody target
Emc10-CKO NM-CKO-00084 Emc10 cancer，nervous system
Emid1-KO NM-KO-190558 Emid1
Eml1-KO NM-KO-190793 Eml1 Usher syndrome
R26-(CAG-LSL-EML4-ALK-IRES-Luciferase-2A-tdTomato) NM-KI-190072 EML4-ALK cancer research
Emp2-KO NM-KO-200172 Emp2 Therapeutic antibody target
En2-KO NM-KO-200173 En2 Therapeutic antibody target
Eno2-(CreERT2) NM-KI-200011 Eno2 Cre recombinase tool
Eno2-(iCre) NM-KI-200012 Eno2 Cre recombinase tool
ENPP1-HU NM-HU-190063 Enpp1 Immunotherapy,cancer research,drug screening
Enpp3-KO NM-KO-200174 Enpp3 Therapeutic antibody target
Enpp6-KO NM-KO-00020 Enpp6 Ether lipid metabolism
ENTPD1-HU NM-HU-200004 Entpd1 Immunotherapy,cancer research,drug screening
Entpd1-KO NM-KO-190078 Entpd1 Immune-related
Entpd2-KO NM-KO-200175 Entpd2 Therapeutic antibody target
Entpd3-KO NM-KO-200176 Entpd3 Therapeutic antibody target
Entpd5-KO NM-KO-200177 Entpd5 Therapeutic antibody target
Entpd6-KO NM-KO-200178 Entpd6 Therapeutic antibody target
Ep300-CKO NM-CKO-190021 Ep300 Epigenetic
Epb42-KO NM-KO-200179 Epb42 Therapeutic antibody target
Epcam-(CreERT2) NM-KI-00084 Epcam
Epha1-KO NM-KO-191127 Epha1 Nervous system,cancer
Epha10-KO NM-KO-200180 Epha10 Therapeutic antibody target
Epha2-KO NM-KO-200181 Epha2 Therapeutic antibody target
Epha4-KO NM-KO-200182 Epha4 Therapeutic antibody target
Epha5-KO NM-KO-200183 Epha5 Therapeutic antibody target
Epha7-KO NM-KO-200184 Epha7 Therapeutic antibody target
Ephb2-KO NM-KO-190271 Ephb2 Immune-related
Ephb3-KO NM-KO-200185 Ephb3 Therapeutic antibody target
Ephx2-KO NM-KO-190954 Ephx2 Endocrine and metabolic systems, blood pressure, arachidonic acid metabolism
Epx-KO NM-KO-190794 Epx Eosinophil peroxidase deficiency
Epx-(iCre) NM-KI-190104 Epx Cre recombinase tool
R26-(CAG-LSL-ERBB2(exon20 insertion)-IRES-Luciferase-2A-EGFP) NM-KI-190071 ERBB2 cancer research
Ereg-KO NM-KO-200186 Ereg Therapeutic antibody target
Erfe-KO NM-KO-200187 Erfe Therapeutic antibody target
Ergic1-KO NM-KO-200188 Ergic1 Therapeutic antibody target
Ermap-KO NM-KO-200189 Ermap Therapeutic antibody target
Ern1-CKO NM-CKO-00077 Ern1
Ero1l-KO NM-KO-191073 Ero1l Endoplasmic reticulum stress-induced apoptosis, cell response to hypoxia
Esr1-KO NM-KO-190631 Esr1 breast cancer, endometrial cancer, and osteoporosis
Esr2-KO NM-KO-200190 Esr2 Therapeutic antibody target
Esrra-CKO NM-CKO-00039 Esrra Metabolism，Metabolism of lipids and lipoproteins，Mitochondrial biogenesis
Ets1-KO NM-KO-190795 Ets1 Hematopoietic, immune
Exoc6b-CKO NM-CKO-00138 Exoc6b
R26-(CAG-LSL-EZH2(Y646N)-IRES-Luciferase-2A-tdTomato) NM-KI-190073 EZH2 cancer research
Ezh2-CKO NM-CKO-190022 Ezh2 Epigenetic
F11-KO NM-KO-200191 F11 Therapeutic antibody target
F11r-KO NM-KO-200192 F11r Therapeutic antibody target
F12-KO NM-KO-200193 F12 Therapeutic antibody target
F8-KO NM-KO-191184 F8
F8-KO NM-KO-00012 F8 Hemophilia A;HEMA
F9-KO NM-KO-18046 F9 factor IX (F9) function and gene therapy
Faap100-KO NM-KO-190272 Faap100 Immune-related
Fabp4-KO NM-KO-200194 Fabp4 Therapeutic antibody target
Faf1-KO NM-KO-191163 Faf1 Interaction of Fas ligand (TNFSF6) with the FAS antigen (TNFRSF6) mediates programmed cell death, also called apoptosis, in a number of organ systems.
Fah-KO NM-KO-191202 Fah Tyrosinemia type I research
Fam162a-KO NM-KO-191090 Fam162a Apoptosis,tumor
Fam19a2-KO NM-KO-00045 Fam19a2
Fam220a-KO NM-KO-190273 Fam220a Immune-related
Fap-KO NM-KO-190079 Fap Immune-related
Fas-KO NM-KO-191206 Fas Immune-related
Fas-KO NM-KO-190080 Fas Immune-related
Fasl-KO NM-KO-190541 Fasl Cancer related;systemic lupus erythematosus related
Fat2-KO NM-KO-190955 Fat2 Cell adhesion molecule,cell proliferation,cerebellar development
Fat3-KO NM-KO-190956 Fat3 Visual, nervous system
Fau-CKO NM-CKO-00048 Fau
Fbln2-KO NM-KO-200195 Fbln2 Therapeutic antibody target
Fbln5-KO NM-KO-190274 Fbln5 Immune-related
Fbln7-CKO NM-CKO-00120 Fbln7
Fbp1-KO NM-KO-190796 Fbp1 Hypoglycemia and metabolic acidosis
Fbxl16-KO NM-KO-190797 Fbxl16 Mouse Aging
Fbxo9-KO NM-KO-190957 Fbxo9
Fbxw11-KO NM-KO-190696 Fbxw11 phosphorylation-dependent ubiquitination
Fcer1a-KO NM-KO-190798 Fcer1a allergic response
Fcer1g-KO NM-KO-190187 Fcer1g Immune-related
Fcer2a-KO NM-KO-190799 Fcer2a immune related
Fcgr1-KO NM-KO-18033 Fcgr1 immunodeficiency, immune system
FCGR2B-HU NM-HU-2000010 Fcgr2b Immunotherapy,cancer research,drug screening
Fcgr2b/Fcgr3/Fcgr4-KO NM-KO-18037 Fcgr2b，Fcgr3，Fcgr4 inflammation,autoimmunity
Fcgr2b-KO NM-KO-00130 Fcgr2b immune system
Fcgr3-KO NM-KO-190562 Fcgr3 Immune-related
Fcgr3-KO NM-KO-190189 Fcgr3 Immune-related
Fcgr4-KO NM-KO-200196 Fcgr4 Therapeutic antibody target
FCGRT-HU(NOD-scid) NM-HU-200006 Fcgrt Immunotherapy,cancer research,drug screening
FcRn-HU NM-HU-190070 Fcgrt Immunotherapy,cancer research,drug screening
FcRn-HU NM-HU-00109 Fcgrt cancer research,Immunotherapy,drug screening
R26-(hFcRn) NM-KI-00081 FCGRT cancer research；Immunotherapy,drug screening
Fcgrt-KO NM-KO-00133 Fcgrt Immunotherapy,drug screening
Fcmr-KO NM-KO-200197 Fcmr Therapeutic antibody target
Fcrl1-KO NM-KO-200198 Fcrl1 Therapeutic antibody target
Fcrl5-KO NM-KO-190081 Fcrl5 Immune-related
Fem1b-KO NM-KO-191164 Fem1b mediating apoptosis
R26-Fen1 NM-KI-00126 Fen1
Fgb-KO NM-KO-200199 Fgb Therapeutic antibody target
Fgf1-KO NM-KO-200200 Fgf1 Therapeutic antibody target
Fgf12-KO NM-KO-190958 Fgf12 Fibroblast growth factor, VSMC lineage differentiation
Fgf2-KO NM-KO-200201 Fgf2 Therapeutic antibody target
Fgf21-KO NM-KO-190275 Fgf21 Immune-related
Fgf21-CKO NM-CKO-00136 Fgf21
Fgf4-KO NM-KO-190701 Fgf4 Cancer-related genes
Fgf7-KO NM-KO-200202 Fgf7 Therapeutic antibody target
R26-(CAG-LSL-FGFR2(S320C)-IRES-Luciferase-2A-EGFP) NM-KI-190079 FGFR2 cancer research
R26-(CAG-LSL-FGFR2(K659N)-IRES-Luciferase-2A-EGFP) NM-KI-190078 FGFR2 cancer research
R26-(CAG-LSL-FGFR2(W290C)-IRES-Luciferase-2A-EGFP) NM-KI-190080 FGFR2 cancer research
R26-(CAG-LSL-FGFR3(K562E)-IRES-Luciferase-2A-EGFP) NM-KI-190081 FGFR3 cancer research
R26-(CAG-LSL-FGFR3(S249C)-IRES-Luciferase-2A-EGFP) NM-KI-190082 FGFR3 cancer research
R26-(CAG-LSL-FGFR3-IRES-Luciferase-2A-EGFP) NM-KI-190083 FGFR3 cancer research
Fgfr4-KO NM-KO-200203 Fgfr4 Therapeutic antibody target
Fhit-KO NM-KO-190624 Fhit The protein encoded by this gene is a P1-P3-bis(5'-adenosyl) triphosphate hydrolase involved in purine metabolism.  In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. The encoded protein is also a tumor suppressor, as loss of its activity results in replication stress and DNA damage.
Fjx1-KO NM-KO-190959 Fjx1 Nervous system, hippocampal neuron dendritic complexity
Fkbp5-KO NM-KO-190276 Fkbp5 Immune-related
Flna-KO NM-KO-200204 Flna Therapeutic antibody target
Flt3-DreERT2 NM-KI-190115 Flt3 Tool Mice
Flt3-KO NM-KO-190082 Flt3 Immune-related
Fmod-KO NM-KO-190277 Fmod Immune-related
Fndc1-KO NM-KO-200205 Fndc1 Therapeutic antibody target
Fndc5-KO NM-KO-190278 Fndc5 Immune-related
Folh1-KO NM-KO-200206 Folh1 Therapeutic antibody target
Fos-(2A-tdTomato) NM-KI-190048 Fos fluorescent reporter mice
Fos-(2A-Venus-luci） NM-KI-190049 Fos fluorescent reporter mice
Fos-KO NM-KO-190083 Fos Immune-related
Fos-(Venus-Luci) NM-KI-18044 Fos
Foxl1-CreERT2 NM-KI-00135 Foxl1
Foxn1-KO(M-NSG) NM-KO-190422 Foxn1 Immune-related,immunodeficiency,immune system,transplantation research
Foxn1-KO NM-KO-00052 Foxn1 immune system
Foxo3-KO NM-KO-190084 Foxo3 Immune-related
Foxp3-(IRES-tdTomato-2A-CreERT2) NM-KI-190120 Foxp3 Cre tool mouse
Foxp3-(tdTomato-2A-iCre) NM-KI-190119 Foxp3 Tool Mice
Foxp3-(IRES-DTREGFP) NM-KI-190046 Foxp3 DTR mouse
Foxp3-(V5-Avi tag-IRES-luci-2A-tdTomato) NM-KI-18034 Foxp3 gene tracing
Frat1-KO NM-KO-190676 Frat1 Cancer-related genes
Frzb-KO NM-KO-190697 Frzb Female-specific osteoarthritis (OA) related
Fshb-KO NM-KO-200207 Fshb Therapeutic antibody target
Fshr-KO NM-KO-200208 Fshr Therapeutic antibody target
Fst-KO NM-KO-190279 Fst Immune-related
Fstl3-KO NM-KO-200209 Fstl3 Therapeutic antibody target
Fto-CKO NM-CKO-190005 Fto Epigenetic
R26-(CAG-LSL-3xFLAG-Fto-IRES-EGFP) NM-KI-190055 Fto mRNA methylation
Fut4-KO NM-KO-200210 Fut4 Therapeutic antibody target
Fzd1-KO NM-KO-190677 Fzd1
Fzd10-KO NM-KO-200211 Fzd10 Therapeutic antibody target
Fzd4-KO NM-KO-190678 Fzd4 positive regulator of the Wingless type MMTV integration site signaling pathway
Fzd6-KO NM-KO-190679 Fzd6 Cancer-related genes
Fzd7-KO NM-KO-190680 Fzd7 Cancer-related genes
Fzd8-KO NM-KO-190681 Fzd8 Cancer-related genes
Fzd9-KO NM-KO-190682 Fzd9 Williams syndrome related
G6pd2-KO NM-KO-190800 G6pd2
Gaa-KO NM-KO-190085 Gaa Immune-related
Gabbr2-KO NM-KO-190960 Gabbr2 Nervous system, thermal or mechanical stimulation of epilepsy, pain, anxiety and depression
Gabra1-KO NM-KO-190570 Gabra1 Epilepsy research related
Gabra2-KO NM-KO-190571 Gabra2
Gabra3-KO NM-KO-200212 Gabra3 Therapeutic antibody target
Gabra4-KO NM-KO-190572 Gabra4 Autism research related
Gabra5-KO NM-KO-190573 Gabra5
Gabra6-KO NM-KO-190574 Gabra6
Gabrb1-KO NM-KO-190575 Gabrb1 Related to schizophrenia research
Gabre-KO NM-KO-190576 Gabre This gene encodes the gamma-aminobutyric acid (GABA) A receptor which is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system.
Gabrg2-KO NM-KO-190577 Gabrg2 This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammlian brain, where it acts at GABA-A receptors, which are ligand-gated chloride channels. Mutations in this gene have been associated with epilepsy and febrile seizures.
Gabrg3-KO NM-KO-190578 Gabrg3 This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels.
Gabrq-KO NM-KO-190579 Gabrq This gene encodes the theta subunit of the GABA A receptor,The GABA A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system.
Gabrr1-KO NM-KO-190580 Gabrr1 GABRR1 is a member of the rho subunit family.
Gabrr2-KO NM-KO-190581 Gabrr2 The protein encoded by this gene is a member of the rho subunit family and is a component of the GABA type A receptor complex. This gene exists on chromosome 6q next to the gene encoding the rho 1 subunit of the GABA type A receptor, in a region thought to be associated with susceptibility for psychiatric disorders and epilepsy. Polymorphisms in this gene may also be associated with alcohol dependence, and general cognitive ability.
Gad2-KO NM-KO-200213 Gad2 Therapeutic antibody target
Gadd45b-KO NM-KO-190801 Gadd45b NF-KB pathway
Gal-KO NM-KO-190086 Gal Immune-related
Galk1-KO NM-KO-200214 Galk1 Therapeutic antibody target
Galnt5-KO NM-KO-191141 Galnt5
Galr1-KO NM-KO-190637 Galr1 nervous system
Ganab-KO NM-KO-190280 Ganab Immune-related
Garnl3-CKO NM-CKO-00007 Garnl3
Gas6-KO NM-KO-200215 Gas6 Therapeutic antibody target
Gast-KO NM-KO-190087 Gast Immune-related
Gba-(D427V) NM-KI-18060 Gba
Gcg-KO NM-KO-200216 Gcg Therapeutic antibody target
Gcgr-KO NM-KO-200217 Gcgr Therapeutic antibody target
Gchfr-KO NM-KO-190961 Gchfr Liver phenylalanine metabolism, production of biogenic amine neurotransmitters and nitric oxide
Gdf15-KO NM-KO-200218 Gdf15 Therapeutic antibody target
Gdf2-KO NM-KO-200219 Gdf2 Therapeutic antibody target
Gdi2-KO NM-KO-190281 Gdi2 Immune-related
Gem-KO NM-KO-200220 Gem Therapeutic antibody target
Gfap-KO NM-KO-190802 Gfap Mouse Aging，Alexander disease
Gfap-(IRES-Venus-Luciferase) NM-KI-190022 Gfap nervous system
R26-(SA-RNR-GFPDTR-FWF-pA) NM-KI-18013 GFPDTR GFPDTR tool mice
Gfra2-KO NM-KO-200221 Gfra2 Therapeutic antibody target
Gfra4-KO NM-KO-200222 Gfra4 Therapeutic antibody target
Gfral-KO NM-KO-200223 Gfral Therapeutic antibody target
Gh-KO NM-KO-190648 Gh Cardiovascular diseases
Ghr-KO NM-KO-190649 Ghr Cardiovascular diseases
Ghrl-KO NM-KO-190645 Ghrl metabolic disease
Ghsr-KO NM-KO-00007 Ghsr digestive system,metabolism
Gip-KO NM-KO-200224 Gip Therapeutic antibody target
Gipr-KO NM-KO-200225 Gipr Therapeutic antibody target
Gja1-(2A-DreERT2) NM-KI-200026 Gja1 Dre recombinase tool
Gjb6-KO NM-KO-190962 Gjb6 Auditory, auditory hair cell degeneration and intra-cochlear potential
Gjc3-KO NM-KO-190282 Gjc3 Immune-related
Gkn2-CKO NM-CKO-00080 Gkn2 homeostasis/metabolism
Glp1r-KO NM-KO-190803 Glp1r Diabetes
Glp2r-KO NM-KO-200574 Glp2r Glucagon Like Peptide 2 Receptor
Glud1-KO NM-KO-191156 Glud1 Activating mutations in this gene are a common cause of congenital hyperinsulinism.
Glul-KO NM-KO-191157 Glul this gene was observed in some primary liver cancer samples.
Glyat-KO NM-KO-190088 Glyat Immune-related
Gm2a-KO NM-KO-200226 Gm2a Therapeutic antibody target
Gmfb-KO NM-KO-200227 Gmfb Therapeutic antibody target
Gnao1-KO NM-KO-190804 Gnao1 Alzheimer's Disease related
Gnaq-KO NM-KO-190963 Gnaq Platelet activation and aggregation, pigmentation
Gnb2-KO NM-KO-190805 Gnb2 Alzheimer's Disease related
Gnb4-KO NM-KO-190806 Gnb4 Alzheimer's Disease related
Gng10-KO NM-KO-190807 Gng10 Alzheimer's Disease related
Gng11-KO NM-KO-190808 Gng11 Alzheimer's Disease related
Gng4-KO NM-KO-190809 Gng4 Alzheimer's Disease related
Gng7-KO NM-KO-190810 Gng7 Alzheimer's Disease related
Gng8-KO NM-KO-190811 Gng8 Alzheimer's Disease related
Gngt1-KO NM-KO-190812 Gngt1 Alzheimer's Disease related
Gngt2-KO NM-KO-190813 Gngt2 Alzheimer's Disease related
Gnrhr-KO NM-KO-200228 Gnrhr Therapeutic antibody target
Gp1ba-KO NM-KO-200229 Gp1ba Therapeutic antibody target
Gp6-KO NM-KO-200230 Gp6 Therapeutic antibody target
Gpa33-KO NM-KO-200231 Gpa33 Therapeutic antibody target
Gpam-KO NM-KO-190283 Gpam Immune-related
Gpbar1-KO NM-KO-200576 Gpbar1 G Protein-Coupled Bile Acid Receptor 1
Gpc1-KO NM-KO-200232 Gpc1 Therapeutic antibody target
Gpc2-KO NM-KO-200233 Gpc2 Therapeutic antibody target
Gpc5-KO NM-KO-190964 Gpc5 Cell division and growth regulation, tumor
Gpd1-KO NM-KO-190814 Gpd1 Diabetes
Gpi1-KO NM-KO-190534 Gpi1 neurotrophic factor，lymphokine
Gpnmb-KO NM-KO-200234 Gpnmb Therapeutic antibody target
Gpr1-KO NM-KO-00057 Gpr1
Gpr142-KO NM-KO-00058 Gpr142
Gpr152-KO NM-KO-190284 Gpr152 Immune-related
Gpr156-CKO NM-CKO-00099 Gpr156
Gpr160-KO NM-KO-00061 Gpr160
Gpr173-KO NM-KO-200235 Gpr173 Therapeutic antibody target
Gpr183-KO NM-KO-190285 Gpr183 Immune-related
Gpr20-KO NM-KO-200236 Gpr20 Therapeutic antibody target
Gpr26-KO NM-KO-00053 Gpr26 immune system
Gpr37-KO NM-KO-190965 Gpr37 Nervous system, endocrine
Gpr61-KO NM-KO-00060 Gpr61
Gpr83-KO NM-KO-190090 Gpr83 Immune-related
Gpr87-KO NM-KO-200237 Gpr87 Therapeutic antibody target
Gpr89-Prkab2-KO NM-KO-18055 Gpr89，Prkab2
Gprc5d-KO NM-KO-200238 Gprc5d Therapeutic antibody target
Gprc6a-CKO NM-CKO-00098 Gprc6a nervous system
Gpx1-KO NM-KO-190966 Gpx1 Oxidative stress, ischemia/reperfusion and cold-induced brain injury
Gria1-KO NM-KO-190582 Gria1 Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes.This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors.
Gria3-KO NM-KO-190967 Gria3 Nervous system, LTP action, epilepsy
Grik1-KO NM-KO-190583 Grik1 This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels.
Grik2-KO NM-KO-190584 Grik2 This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels.Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes.
Grik4-KO NM-KO-190585 Grik4 This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members.
Grik5-KO NM-KO-190586 Grik5 This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members.
Grin2a-KO NM-KO-190968 Grin2a Nervous system, LTP action, dopamine and serotonin metabolism
Grin2c-KO NM-KO-190587 Grin2c This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptor, which is a subtype of ionotropic glutamate receptor. NMDA receptors are found in the central nervous system, are permeable to cations and have an important role in physiological processes such as learning, memory, and synaptic development.
Grm1-KO NM-KO-190588 Grm1 This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer.
Grm2-KO NM-KO-200239 Grm2 Therapeutic antibody target
Grm3-KO NM-KO-190589 Grm3 This gene encodes a metabotropic glutamate receptor. This receptors are linked to the inhibition of the cyclic AMP cascade。
Grm4-KO NM-KO-190590 Grm4 This gene encodes a metabotropic glutamate receptor. This receptors are linked to the inhibition of the cyclic AMP cascade。
Grm5-KO NM-KO-190969 Grm5 Endocrine, corticosteroid synergism
Grm6-KO NM-KO-190591 Grm6 This gene encodes a metabotropic glutamate receptor. This receptors are linked to the inhibition of the cyclic AMP cascade。
Grm7-KO NM-KO-190592 Grm7 This gene encodes a metabotropic glutamate receptor. This receptors are linked to the inhibition of the cyclic AMP cascade。
Grm8-KO NM-KO-190593 Grm8 This gene encodes a metabotropic glutamate receptor. This receptors are linked to the inhibition of the cyclic AMP cascade。
Grp-KO NM-KO-190651 Grp lung, colon, stomach, pancreas, breast, and prostate cancer
Grpr-KO NM-KO-190286 Grpr Immune-related
Gsdmd-CKO NM-CKO-190060 Gsdmd cell pyroptosis,cell apoptosis
Gsk3a-KO NM-KO-190815 Gsk3a Alzheimer's Disease related
R26-(CAG-LSL-HA-GiDREADD（hM4Di）-mCitrine) NM-KI-190093 Gt(ROSA)26Sor Chemical Genetics studies.The inhibitory GiDREADD(hM4Di) could silence the activity of neurons following administration of CNO.
R26-(SA-2xpA-CAG-EGFP) NM-KI-190088 Gt(ROSA)26Sor Reporter mice, EGFP
R26-(CAG-EGFP)1 NM-KI-190089 Gt(ROSA)26Sor Reporter mice, EGFP
R26-(CAG-EGFP)2 NM-KI-190090 Gt(ROSA)26Sor Reporter mice, EGFP
R26-(CAG-LSL-3xFLAG-Mettl14-IRES-EGFP) NM-KI-190017 Gt(ROSA)26Sor mRNA methylation
R26-(CAG-LSL-3xFLAG-Ythdf2-IRES-EGFP) NM-KI-190018 Gt(ROSA)26Sor mRNA methylation
R26-(TetO-Dre-IRES-BFP) NM-KI-190020 Gt(ROSA)26Sor Dre recombinase tool
R26-(CAG-LSL-Avi-EGFP-Rpl10a) NM-KI-190005 Gt(ROSA)26Sor ribosome
R26-(CAG-LSL-EGFR-del19) NM-KI-190004 Gt(ROSA)26Sor cancer research
R26-(CAG-LSL-FGFR2-luciferase-EGFP) NM-KI-190007 Gt(ROSA)26Sor cancer
R26-(CAG-LSL-HER2-luciferase-EGFP) NM-KI-190008 Gt(ROSA)26Sor cancer
R26-(CAG-LSL-EGFR T790M-del19-luciferase-tdTomato) NM-KI-190009 Gt(ROSA)26Sor cancer
R26-(CAG-LSL-EML4-ALK(F1174L)-luciferase-tdTomato) NM-KI-190010 Gt(ROSA)26Sor cancer
R26-(Alb-TK-luc-EGFP) NM-KI-18040 Gt(ROSA)26Sor
R26-(SA-EGFP-polyA) NM-KI-18024 Gt(ROSA)26Sor Reporter mice,EGFP
R26-(Luc-EGFP) NM-KI-00087 Gt(ROSA)26Sor gene tracing
R26-(Renilla-Luc) NM-KI-00091 Gt(ROSA)26Sor
R26-(PB-V5) NM-KI-00065 Gt(ROSA)26Sor gene editing, gene modification
R26-(PhiC31) NM-KI-00088 Gt(ROSA)26Sor
R26-(CaMPARI) NM-KI-00090 Gt(ROSA)26Sor nervous system
Gtf3a-KO NM-KO-200240 Gtf3a Therapeutic antibody target
Gucy2c-KO NM-KO-200241 Gucy2c Therapeutic antibody target
Gykl1-KO NM-KO-200242 Gykl1 Therapeutic antibody target
Gypa-KO NM-KO-200243 Gypa Therapeutic antibody target
Gzma-KO NM-KO-190188 Gzma Immune-related
Gzmb-KO NM-KO-190091 Gzmb Immune-related
H19-KO NM-KO-18045 H19 H19 gene function
H2-Ab1/H2-Ea-ps-KO(M-NSG) NM-NSG-003 H2-Ab1，H2-Ea-ps immunodeficiency,immune system,transplantation research
H2-Ab1/H2-Ea-ps-KO(Nod-Scid) NM-KO-18057 H2-Ab1，H2-Ea-ps immune system
H2-Ab1/H2-Ea-ps-KO NM-KO-18032 H2-Ab1，H2-Ea-ps immune system
H2-DMa-KO NM-KO-190816 H2-DMa immune related
H2-Eb1-KO NM-KO-191128 H2-Eb1 Immune system, inflammation
H2-M3-KO NM-KO-200244 H2-M3 Therapeutic antibody target
Hamp-KO NM-KO-200245 Hamp Therapeutic antibody target
Hars-KO NM-KO-200246 Hars Therapeutic antibody target
Havcr1-KO NM-KO-200247 Havcr1 Therapeutic antibody target
Havcr2-KO NM-KO-18049 Havcr2
TIM3-HU NM-HU-00054 Havcr2 Immunotherapy,cancer research,drug screening
Hbp1-KO NM-KO-190092 Hbp1 Immune-related
Hc-KO NM-KO-190191 Hc Immune-related
Hcrt-KO NM-KO-190639 Hcrt sleep and arousal
Hcrtr1-KO NM-KO-190640 Hcrtr1 sleep and arousal
Hcrtr2-KO NM-KO-190610 Hcrtr2 The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior.
Hdac10-CKO NM-CKO-00127 Hdac10 cancer research
Hdac11-KO NM-KO-00086 Hdac11 immune system,HDAC gene function research, epigenetic research, etc.
Hdac2-CKO NM-CKO-00123 Hdac2
Hdac4-KO NM-KO-00075 Hdac4 cancer research,HDAC function study, epigenetic research
Hdac5-CKO NM-CKO-00132 Hdac5 cancer research
Hdac6-CKO NM-CKO-18013 Hdac6
Hdac6-KO NM-KO-18009 Hdac6 HDAC gene function research, epigenetic research, etc.
Hdac9-KO NM-KO-190709 Hdac9 Epigenetic modifications related
Hdac9-CKO NM-CKO-00125 Hdac9
Hdgf-KO NM-KO-200248 Hdgf Therapeutic antibody target
Hebp1-CKO NM-CKO-00137 Hebp1
Hes2-KO NM-KO-190287 Hes2 Immune-related
HGF-HU NM-HU-190062 Hgf Immunotherapy,cancer research,drug screening
Hif1a-CKO NM-CKO-190065 Hif1a Hypoxia-inducible factor 1-alpha,Metabolism and cancer research
Hif1an-KO NM-KO-190288 Hif1an Immune-related
Hif3a-KO NM-KO-191062 Hif3a Hypoxia-inducible factor, lung remodeling
Higd1a-KO NM-KO-200249 Higd1a Therapeutic antibody target
Hint2-CKO NM-CKO-00086 Hint2
Hip1-KO NM-KO-190970 Hip1 Nervous system, Huntington's disease
Hipk2-KO NM-KO-190971 Hipk2 Nervous system, tumor
Hmcn1-KO NM-KO-190972 Hmcn1 Age-related macular degeneration,
Hmgb2-CKO NM-CKO-190073 Hmgb2 Apoptotic cleavage of cellular proteins and Granzyme Pathway related
R26-(CAG-LNL-Hmgb2-3xFlag) NM-KI-190130 Hmgb2 Apoptotic cleavage of cellular proteins and Granzyme Pathway related
Hnf4a-CKO NM-CKO-190062 Hnf4a Transcriptional regulator, insulin secretion related
Hopx-(2A-DreERT2） NM-KI-190035 Hopx Dre recombinase tool
Hoxb5-(2A-tdTomato） NM-KI-190047 Hoxb5 fluorescent reporter mice
Hpca-KO NM-KO-190973 Hpca Nervous system, hippocampus and cortical neurodegeneration
Hpn-KO NM-KO-200250 Hpn Therapeutic antibody target
Hpse-KO NM-KO-190289 Hpse Immune-related
Hras-KO NM-KO-191092 Hras Costello syndrome; tumors, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma
Hrh1-KO NM-KO-190599 Hrh1 The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. It has been associated with multiple processes, including memory and learning, circadian rhythm, and thermoregulation. It is also known to contribute to the pathophysiology of allergic diseases such as atopic dermatitis, asthma, anaphylaxis and allergic rhinitis.
Hrh4-KO NM-KO-190600 Hrh4 This gene encodes a histamine receptor that is predominantly expressed in haematopoietic cells. The protein is thought to play a role in inflammation and allergy reponses.
Hs6st2-KO NM-KO-200251 Hs6st2 Therapeutic antibody target
Hsd17b10-KO NM-KO-190817 Hsd17b10 Alzheimer's disease research related
Hsf1-KO NM-KO-190818 Hsf1 regulation of lifespan
Hsp90aa1-KO NM-KO-190731 Hsp90aa1 An inducible molecular chaperone
Hspa12a-KO NM-KO-190705 Hspa12a molecular chaperone
Hspa13-CKO NM-CKO-00092 Hspa13 nervous system，neurological，vestibular，aging related research
Hspa1b-KO NM-KO-200252 Hspa1b Therapeutic antibody target
Hspa4-KO NM-KO-200253 Hspa4 Therapeutic antibody target
Hspa4l-KO NM-KO-190974 Hspa4l Sperm maturity and vitality, male infertility
Hspb1-KO NM-KO-200254 Hspb1 Therapeutic antibody target
Hspbap1-KO NM-KO-191142 Hspbap1 intractable epilepsy
Htr1a-KO NM-KO-190594 Htr1a This gene encodes a G protein-coupled receptor for 5-hydroxytryptamine (serotonin), and belongs to the 5-hydroxytryptamine receptor subfamily. Serotonin has been implicated in a number of physiologic processes and pathologic conditions. Inactivation of this gene in mice results in behavior consistent with an increased anxiety and stress response. Mutation in the promoter of this gene has been associated with menstrual cycle-dependent periodic fevers.
Htr1d-KO NM-KO-190595 Htr1d
Htr1f-KO NM-KO-190596 Htr1f
Htr2a-KO NM-KO-190975 Htr2a Nervous system, intestinal epithelial cells
Htr3a-KO NM-KO-190597 Htr3a The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen.
Htr4-KO NM-KO-190290 Htr4 Immune-related
Htr7-KO NM-KO-190598 Htr7 The serotonin receptor encoded by this gene belongs to the superfamily of G protein-coupled receptors and the gene is a candidate locus for involvement in autistic disorder and other neuropsychiatric disorders.
Htra1-KO NM-KO-200255 Htra1 Therapeutic antibody target
Iapp-KO NM-KO-190664 Iapp type 1 and advanced type 2 diabetes
Icam1-KO NM-KO-190819 Icam1 immune system
Icam2-KO NM-KO-190820 Icam2 immune system
Icam5-KO NM-KO-200256 Icam5 Therapeutic antibody target
ICOS-HU NM-HU-190030 Icos Immunotherapy,cancer research,drug screening
Icos-KO NM-KO-190093 Icos Immune-related
ICOS&ICOSL-HU NM-HU-18018 Icos，Icosl Immunotherapy,cancer research,drug screening
ICOS-HU NM-HU-00052 Icos Immunotherapy,cancer research,drug screening
Icosl-KO NM-KO-190721 Icosl Immune related
ICOSL-HU NM-HU-00095 Icosl Immunotherapy,cancer research,drug screening
Ide-KO NM-KO-190821 Ide Alzheimer's disease research related
R26-(CAG-LSL-IDH1(R132H)-IRES-Luciferase-2A-tdTomato) NM-KI-190074 IDH1 cancer research
R26-(CAG-LSL-IDH2(R172K)-IRES-Luciferase-2A-tdTomato) NM-KI-190076 IDH2 cancer research
R26-(CAG-LSL-IDH2(R140Q)-IRES-Luciferase-2A-tdTomato) NM-KI-190075 IDH2 cancer research
PD-1&PD-L1&IDO1-HU NM-HU-00120 Ido1，Pdcd1，Cd274 cancer research,Immunotherapy,drug screening
IDO1-HU NM-HU-00061 Ido1 Immunotherapy,cancer research,drug screening
Ido2-KO NM-KO-200257 Ido2 Therapeutic antibody target
Ier3-KO NM-KO-191079 Ier3 Cardiovascular system; tumor
Ifi44-KO NM-KO-190094 Ifi44 Immune-related
Ifih1-KO NM-KO-190225 Ifih1 Immune-related
Ifna2-KO NM-KO-190527 Ifna2 Interferons
Ifnar1-KO NM-KO-18038 Ifnar1 immune system
Ifnar2-KO NM-KO-190291 Ifnar2 Immune-related
Ifnb1-KO NM-KO-190822 Ifnb1 immune system
Ifne-KO NM-KO-200258 Ifne Therapeutic antibody target
Ifng-(Venus-Luci) NM-KI-18041 Ifng
IFNGR1-HU NM-HU-190076 Ifngr1 Immunotherapy,Cancer research,Drug screening
Ifngr1-KO NM-KO-190432 Ifngr1 immune system
Ifngr1-KO NM-KO-18020 Ifngr1 immune system
Ifngr1&Ifnar1-KO NM-KO-190425 Ifngr1；Ifnar1 immune system
Igdcc4-KO NM-KO-200259 Igdcc4 Therapeutic antibody target
Igfbp3-KO NM-KO-191083 Igfbp3 Insulin-like growth factor binding protein (IGFBP); metabolic system, glucose metabolism, lipid metabolism; cancer
Igfbp5-KO NM-KO-190823 Igfbp5
Igfbp7-KO NM-KO-200260 Igfbp7 Therapeutic antibody target
Ighj4-KO NM-KO-191197 Ighj4 Immune-related
Ighm-KO NM-KO-18024 Ighm immune system,immunodeficiency
Igkj-KO NM-KO-191196 Igkj Immune-related
Igl-KO NM-KO-191198 Igl Immune-related
Igll1-KO NM-KO-200261 Igll1 Therapeutic antibody target
Ikzf4-KO NM-KO-190096 Ikzf4 Immune-related
Il10-CKO NM-CKO-200003 Il10 immune system
Il10-KO NM-KO-190426 Il10 immune system
Il10ra-KO NM-KO-190451 Il10ra Interleukin 10 receptor subunit alpha.Immune system related.
Il10rb-KO NM-KO-190452 Il10rb Belong to the cytokine receptor family.Immune system related.
Il11-KO NM-KO-190293 Il11 Immune-related
Il11-(Luc-EGFP) NM-KI-00036 Il11 Inflammation and immunity, gene tracing
Il11ra1-KO NM-KO-190453 Il11ra1 A member of the hematopoietic cytokine receptor family.Immune system related.
Il12a-KO NM-KO-190454 Il12a Immune system related.This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells.
Il12a-(Luc-EGFP) NM-KI-00024 Il12a Inflammation and immunity, gene tracing
Il12b-KO NM-KO-190455 Il12b Immune system and multiple sclerosis(MS) related.
Il12b-(Luc-EGFP) NM-KI-00025 Il12b Inflammation and immunity, gene tracing
Il12rb1-KO NM-KO-191208 Il12rb1 Immune-related
Il12rb1-KO NM-KO-190294 Il12rb1 Immune-related
Il12rb2-KO NM-KO-190456 Il12rb2 Immune system related.The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy.
IL13-HU NM-HU-190069 Il13 Immunotherapy,cancer research,drug screening
Il13-KO NM-KO-00124 Il13 immune system
Il13ra1-KO NM-KO-190457 Il13ra1 Immune system related.
Il13ra2-KO NM-KO-190458 Il13ra2 Immune system related.
Il15-KO NM-KO-190459 Il15 Inflammation and immune system related.
Il15-(Luc-EGFP) NM-KI-00027 Il15 Inflammation and immunity, gene tracing
Il15ra-KO NM-KO-190460 Il15ra Immune system and cell proliferation related.
Il16-KO NM-KO-200262 Il16 Therapeutic antibody target
Il16-(Luc-EGFP) NM-KI-00028 Il16 Inflammation and immunity, gene tracing
IL17A-HU NM-HU-00042 Il17a Immunotherapy,cancer research,drug screening
Il17a-(CreERT2) NM-KI-00059 Il17a Immune system
Il17a-KO NM-KO-00131 Il17a immune system
Il17b-KO NM-KO-190461 Il17b Immune system related.T cell related.
Il17b-(Luc-EGFP) NM-KI-00029 Il17b Inflammation and immunity, gene tracing
Il17c-KO NM-KO-190462 Il17c Immune system related.T cell related.
Il17c-(Luc-EGFP) NM-KI-00030 Il17c Inflammation and immunity, gene tracing
Il17d-KO NM-KO-190463 Il17d Immune system related.
Il17f-KO NM-KO-190464 Il17f Immune system related.T cell related.
IL17F-HU NM-HU-190007 Il17f Immune-related
Il17f-(Luc-EGFP) NM-KI-00031 Il17f Inflammation and immunity, gene tracing
Il17ra-KO NM-KO-190465 Il17ra Immune system related.T-lymphocytes and inflammatory and autoimmune diseases related.
IL17RA-HU NM-HU-190049 Il17ra Immunotherapy,cancer research,drug screening
Il17rb-KO NM-KO-190466 Il17rb Immune system related.
Il17rc-KO NM-KO-190467 Il17rc Immune system related.
Il17rd-KO NM-KO-190468 Il17rd Immune system related.
Il17re-KO NM-KO-190295 Il17re Immune-related
Il18-KO NM-KO-190469 Il18 Immune system related.
Il18-(Luc-EGFP) NM-KI-00032 Il18 Inflammation and immunity,gene tracing
Il18bp-KO NM-KO-190470 Il18bp Immune system related.
Il18r1-KO NM-KO-190471 Il18r1 Cytokine receptor.Immune system related.
Il18rap-KO NM-KO-190472 Il18rap Proinflammatory cytokine.Immune system related.
Il19-KO NM-KO-190473 Il19 Immune system related.
Il19-(Luc-EGFP) NM-KI-00033 Il19 Inflammation and immunity, gene tracing
Il1a-KO NM-KO-190474 Il1a Immune system related.Rheumatoid arthritis and Alzheimer's disease research related.
Il1a-(Luc-EGFP) NM-KI-00009 Il1a Inflammation and immunity, gene tracing
Il1b-KO NM-KO-190475 Il1b Immune system related.
IL1B-HU NM-HU-190047 Il1b Immunotherapy,cancer research,drug screening
Il1b-(Luc-EGFP) NM-KI-00010 Il1b Inflammation and immunity,gene tracing
Il1b-Luc NM-TG-00001 Il1b anti-inflammatory,inflammatory process
Il1bos-KO NM-KO-190476 Il1bos
Il1f10-KO NM-KO-190566 Il1f10 immune system
Il1f10-(Luc-EGFP) NM-KI-00060 Il1f10 Inflammation and immunity, gene tracing
Il1f10-KO NM-KO-00103 Il1f10 immune system
Il1f5-KO NM-KO-190477 Il1f5 Immune system related.
Il1f6-KO NM-KO-00097 Il1f6 immune system
Il1f6-(Luc-EGFP) NM-KI-00017 Il1f6 Inflammation and immunity, gene tracing
Il1f8-KO NM-KO-190478 Il1f8 Immune system related.
Il1f9-KO NM-KO-190479 Il1f9
Il1f9-(Luc-EGFP) NM-KI-00018 Il1f9 Inflammation and immunity, gene tracing
Il1r1-KO NM-KO-191194 Il1r1 Immune-related
Il1r1-KO NM-KO-190480 Il1r1 Immune and inflammatory responses related.
Il1r2-KO NM-KO-190481 Il1r2 immune system；Cancer-related genes
Il1rap-KO NM-KO-191201 Il1rap Cancer Research, Immunology, Inflammation and Autoimmunity Research. Alzheimer's disease related
Il1rap-KO NM-KO-190445 Il1rap Cancer Research, Immunology, Inflammation and Autoimmunity Research. Alzheimer's disease related
Il1rapl1-KO NM-KO-190482 Il1rapl1 immune system；Disease related genes
Il1rapl2-KO NM-KO-190483 Il1rapl2 immune system
Il1rl1-KO NM-KO-190296 Il1rl1 Immune-related
Il1rl2-KO NM-KO-190484 Il1rl2 immune system
Il1rn-KO NM-KO-190485 Il1rn immune system；Cancer-related genes Candidate cardiovascular disease genes Disease related genes
Il2-KO NM-KO-190486 Il2 immune system
IL2-HU NM-HU-190048 Il2 Immunotherapy,cancer research,drug screening
Il2-(Venus-Luci) NM-KI-18057 Il2 Gene tracing
Il2-CKO NM-CKO-00108 Il2
Il20-KO NM-KO-190487 Il20 immune system
Il20ra-KO NM-KO-190488 Il20ra immune system
Il20rb-KO NM-KO-190489 Il20rb immune system
Il21-KO NM-KO-18040 IL21 immune system
Il21r-KO NM-KO-190490 Il21r immune system；Cancer-related genes；Disease related genes
Il22-KO NM-KO-190491 Il22 Immune System；Intestinal Diseases
Il22ra1-KO NM-KO-190492 Il22ra1 IL22 receptor；Immune System
Il22ra2-KO NM-KO-190493 Il22ra2 Immune System； Regulation of Tumorigenesis in the Colon
Il23a-KO NM-KO-200263 Il23a Therapeutic antibody target
IL23A-HU NM-HU-18030 Il23a Immunotherapy,Cancer research,Drug screening
Il23a-(Luc-EGFP) NM-KI-00057 Il23a Inflammation and immunity, gene tracing
Il23r-KO NM-KO-190097 Il23r Immune-related
Il24-KO NM-KO-190494 Il24 Induced terminal differentiation of melanoma cells；Induce apoptosis in various cancer cells.
Il25-KO NM-KO-00113 Il25 immune system
Il27-KO NM-KO-190495 Il27 Drive rapid expansion of naive CD4(+) T cells;trigger interferon gamma (IFNG) production of naive CD4(+) T cells
Il27ra-KO NM-KO-190496 Il27ra glycosylated transmembrane protein；Immune System
IL2RA-HU NM-HU-190064 Il2ra Immunotherapy,cancer research,drug screening
Il2ra-KO NM-KO-190098 Il2ra Immune-related
Il2rb-KO NM-KO-190497 Il2rb Immune System
IL2RG-HU NM-HU-200007 Il2rg Immunotherapy,cancer research,drug screening
M-NSG NM-NSG-001 Il2rg Immune and hematopoietic research
IL3&CSF2-HU NM-HU-190065 Il3， Csf2 Immunotherapy,cancer research,drug screening
Il3-KO NM-KO-190498 Il3 Support the proliferation of hematopoietic cell types； Possess neurotrophic activity
IL3-HU NM-HU-190009 Il3 Immune-related
Il3-(Luc-EGFP) NM-KI-00020 Il3 Inflammation and immunity, gene tracing
IL31-HU NM-HU-200008 Il31 Immunotherapy,cancer research,drug screening
Il31-KO NM-KO-190499 Il31 promote allergic skin disorders；asthma
Il31ra-KO NM-KO-190500 Il31ra IL31 receptor；Immune System
Il33-KO NM-KO-190436 Il33 immune
Il34-KO NM-KO-190501 Il34 Promotes the differentiation of monocytes and macrophages
Il34-(Luc-EGFP) NM-KI-00035 Il34 Inflammation and immunity, gene tracing
Il3ra-KO NM-KO-190502 Il3ra IL3 receptor；Immune System
Il4-(IRES-tdTomato) NM-KI-200028 Il4 Inflammation and immunity, gene tracing
IL4-HU NM-HU-190071 Il4 Immunotherapy,cancer research,drug screening
Il4-KO NM-KO-190503 Il4 Immune System；pleiotropic cytokine
Il4-(Luc-EGFP) NM-KI-00021 Il4 Inflammation and immunity, gene tracing
Il4ra-KO NM-KO-190504 Il4ra IL4 receptor；Immune System
IL4RA-HU NM-HU-190008 Il4ra Immune-related
Il5-KO NM-KO-190505 Il5 Regulate eosinophil formation, maturation, recruitment and survival
IL5-HU NM-HU-190001 Il5 Immune-related
Il5-(Luc-EGFP) NM-KI-00022 Il5 Inflammation and immunity, gene tracing
Il5ra-KO NM-KO-190506 Il5ra IL5 receptor；Immune System
IL5RA-HU NM-HU-190055 Il5ra Immunotherapy,cancer research,drug screening
IL6&IL6R-HU NM-HU-190025 Il6，Il6ra Immune-related
Il6-KO NM-KO-18029 Il6 immune system,immunodeficiency
Il6-(Luc-EGFP) NM-KI-00011 Il6 Inflammation and immunity,gene tracing
Il6ra-KO NM-KO-190507 Il6ra myeloma，prostate cancer，autoimmune diseases
Il6ra-KO NM-KO-18042 Il6ra inflammatory, immune system
IL6R-HU NM-HU-00044 Il6ra Immunotherapy,cancer research,drug screening
Il6st-KO NM-KO-190508 Il6st Immune System；Regulate myocyte apoptosis
Il7-KO NM-KO-191178 Il7 Immune related
IL7-HU NM-HU-190031 Il7 Immunotherapy,cancer research,drug screening
Il7-(Luc-EGFP) NM-KI-00092 Il7 Inflammation and immunity, gene tracing
Il7-KO NM-KO-00098 Il7 immune system
Il7r-KO NM-KO-190509 Il7r Immune System；Severe combined immunodeficiency
Il9-KO NM-KO-190510 Il9 Asthma;Bronchial hyperresponsiveness disease
IL9-HU NM-HU-18029 Il9 Immunotherapy,Cancer research,Drug screening
Il9-(Luc-EGFP) NM-KI-00023 Il9 Immune system
Il9r-KO NM-KO-190511 Il9r Genetic studies suggested an association of this gene with the development of asthma.
Ildr2-KO NM-KO-18034 Ildr2 Metabolism, endocrine
Ilf2-KO NM-KO-190512 Ilf2 The protein encoded by this gene is a transcription factor required for T-cell expression of the interleukin 2 gene.
Ilf3-KO NM-KO-190513 Ilf3 Gene expression and mRNAs stabilization related.
Iltifb-KO NM-KO-190514 Iltifb
Inhbb-KO NM-KO-200264 Inhbb Therapeutic antibody target
Inpp4b-KO NM-KO-190297 Inpp4b Immune-related
Inppl1-KO NM-KO-190824 Inppl1 Cancer related;diabetes related
Ins1-KO NM-KO-190825 Ins1 diabetes related
Ins2-(C96Y) NM-KI-190096 Ins2 Diabetes related.
Ins2-(DreERT2） NM-KI-190039 Ins2 Dre recombinase tool
Irak1-KO NM-KO-190298 Irak1 Immune-related
Irak1bp1-KO NM-KO-190515 Irak1bp1
Irak2-KO NM-KO-190516 Irak2 IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB.
Irak3-KO NM-KO-190517 Irak3 Mutations in this gene are associated with a susceptibility to asthma.
Irak4-KO NM-KO-190518 Irak4 The protein is essential for most innate immune responses.Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease.
Irf1-KO NM-KO-190099 Irf1 Immune-related
Irf4-KO NM-KO-190100 Irf4 Immune-related
Irf7-KO NM-KO-190826 Irf7 inflammatory response system
Irf8-KO NM-KO-190101 Irf8 Immune-related
Irs1-KO NM-KO-190827 Irs1 diabetes related
Isl1-(CreERT2) NM-KI-00013 Isl1 Cre recombinase tool
Itch-KO NM-KO-190716 Itch Immune related, syndromic multisystem autoimmune disease.
Itga1-KO NM-KO-190717 Itga1 Inflammation and fibrosis reseach.
Itga10-KO NM-KO-200265 Itga10 Therapeutic antibody target
Itga2-KO NM-KO-200266 Itga2 Therapeutic antibody target
Itgad-KO NM-KO-200267 Itgad Therapeutic antibody target
Itgae-KO NM-KO-200268 Itgae Therapeutic antibody target
Itgal-KO NM-KO-200269 Itgal Therapeutic antibody target
Itgax-(tdTomato-luci) NM-KI-190116 Itgax Tool Mice
Itgax-(2A-DreERT2） NM-KI-190032 Itgax Dre recombinase tool
Itgax-(IRES-DTREGFP） NM-KI-190043 Itgax DTR mouse
Itgb2-KO NM-KO-190828 Itgb2 immune system
Itgb3-KO NM-KO-200270 Itgb3 Therapeutic antibody target
Itgb5-KO NM-KO-200271 Itgb5 Therapeutic antibody target
Itgb6-KO NM-KO-200272 Itgb6 Therapeutic antibody target
Itgb7-KO NM-KO-200273 Itgb7 Therapeutic antibody target
Itgbl1-KO NM-KO-190299 Itgbl1 Immune-related
Itk-KO NM-KO-190102 Itk Immune-related
R26-(CAG-LSL-Itpr1-Flag-tdTomato) NM-KI-18046 Itpr1
Itpr2-KO NM-KO-190976 Itpr2 Calcium signaling, endocrine sweat
Itpr3-KO NM-KO-200274 Itpr3 Therapeutic antibody target
Jak3-KO NM-KO-190712 Jak3 Immune related
Jaml-KO NM-KO-200275 Jaml Therapeutic antibody target
Jmy-CKO NM-CKO-00022 Jmy
Jph3-KO NM-KO-191143 Jph3 this gene have been associated with Huntington disease-like 2 (HDL2).
Jtb-KO NM-KO-190300 Jtb Immune-related
Kank1-(2A-DreERT2） NM-KI-190040 Kank1 Dre recombinase tool
Kars-KO NM-KO-200276 Kars Therapeutic antibody target
Kat2a-CKO NM-CKO-190023 Kat2a Epigenetic
Kat6b-CKO NM-CKO-190024 Kat6b Epigenetic
Katnal2-KO NM-KO-191190 Katnal2 Autism research related
Kcna3-KO NM-KO-200277 Kcna3 Therapeutic antibody target
Kcnab1-KO NM-KO-190977 Kcnab1 Potassium channel, nuclear cataract, nervous system, epilepsy
Kcnab2-KO NM-KO-190978 Kcnab2 Potassium ion channel
Kcnc3-KO NM-KO-190979 Kcnc3 Voltage-dependent excitable membrane potassium ion permeability, nervous system, type 13 spinocerebellar ataxia (SCA13), alcohol hypersensitivity
Kcne2-KO NM-KO-200278 Kcne2 Therapeutic antibody target
Kcnh1-KO NM-KO-200279 Kcnh1 Therapeutic antibody target
Kcnh6-KO NM-KO-200280 Kcnh6 Therapeutic antibody target
Kcnip1-KO NM-KO-191144 Kcnip1 in response to changes in the concentration of intracellular calcium.
Kcnj10-KO NM-KO-200281 Kcnj10 Therapeutic antibody target
Kcnj12-KO NM-KO-200282 Kcnj12 Therapeutic antibody target
Kcnj14-KO NM-KO-200283 Kcnj14 Therapeutic antibody target
Kcnj15-KO NM-KO-200284 Kcnj15 Therapeutic antibody target
Kcnj16-KO NM-KO-200285 Kcnj16 Therapeutic antibody target
Kcnj3-KO NM-KO-200286 Kcnj3 Therapeutic antibody target
Kcnj4-KO NM-KO-200287 Kcnj4 Therapeutic antibody target
Kcnj5-KO NM-KO-200288 Kcnj5 Therapeutic antibody target
Kcnj9-KO NM-KO-200289 Kcnj9 Therapeutic antibody target
Kcnk1-KO NM-KO-200290 Kcnk1 Therapeutic antibody target
Kcnma1-KO NM-KO-190557 Kcnma1 BK channel activation research
Kcnmb1-KO NM-KO-191191 Kcnmb1
Kcp-KO NM-KO-190301 Kcp Immune-related
Kctd20-KO NM-KO-190302 Kctd20 Immune-related
Kdm1a-CKO NM-CKO-190025 Kdm1a Epigenetic
Kdm3a-CKO NM-CKO-190026 Kdm3a Epigenetic
Kdm4b-KO NM-KO-190303 Kdm4b Immune-related
Kdm4d-KO NM-KO-190304 Kdm4d Immune-related
Kdm5a-CKO NM-CKO-190027 Kdm5a Epigenetic
Kdm5a-KO NM-KO-190305 Kdm5a Immune-related
Kdm6a-CKO NM-CKO-190054 Kdm6a Epigenetic
Kdr-HU NM-HU-00098 Kdr Immunotherapy,cancer research,drug screening
Kera-KO NM-KO-200291 Kera Therapeutic antibody target
kif18A-KO NM-KO-00008 kif18A male infertility，orchiatrophy，azoospermia
Kir3dl1-KO NM-KO-200292 Kir3dl1 Therapeutic antibody target
Kir3dl2-KO NM-KO-200293 Kir3dl2 Therapeutic antibody target
Kit-(V831M) NM-KI-190023 Kit hematopoieticstem cell 
Kitl-KO NM-KO-190829 Kitl Allergy and Asthma related.
Kl-KO NM-KO-200294 Kl Therapeutic antibody target
Klb-CKO NM-CKO-00135 Klb
Klf14-KO NM-KO-190306 Klf14 Immune-related
Klf9-KO NM-KO-190307 Klf9 Immune-related
Klk1-KO NM-KO-200295 Klk1 Therapeutic antibody target
Klk10-KO NM-KO-200296 Klk10 Therapeutic antibody target
Klk11-KO NM-KO-200297 Klk11 Therapeutic antibody target
Klk12-KO NM-KO-200298 Klk12 Therapeutic antibody target
Klk13-KO NM-KO-200299 Klk13 Therapeutic antibody target
Klk14-KO NM-KO-200300 Klk14 Therapeutic antibody target
Klk15-KO NM-KO-200301 Klk15 Therapeutic antibody target
Klk1b1-KO NM-KO-200302 Klk1b1 Therapeutic antibody target
Klk1b11-KO NM-KO-200303 Klk1b11 Therapeutic antibody target
Klk1b16-KO NM-KO-200304 Klk1b16 Therapeutic antibody target
Klk1b21-KO NM-KO-200305 Klk1b21 Therapeutic antibody target
Klk1b22-KO NM-KO-200306 Klk1b22 Therapeutic antibody target
Klk1b24-KO NM-KO-200307 Klk1b24 Therapeutic antibody target
Klk1b26-KO NM-KO-200308 Klk1b26 Therapeutic antibody target
Klk1b27-KO NM-KO-200309 Klk1b27 Therapeutic antibody target
Klk1b3-KO NM-KO-200310 Klk1b3 Therapeutic antibody target
Klk1b4-KO NM-KO-200311 Klk1b4 Therapeutic antibody target
Klk1b8-KO NM-KO-200312 Klk1b8 Therapeutic antibody target
Klk1b9-KO NM-KO-200313 Klk1b9 Therapeutic antibody target
Klk4-KO NM-KO-200314 Klk4 Therapeutic antibody target
Klk5-KO NM-KO-200315 Klk5 Therapeutic antibody target
Klk6-KO NM-KO-200316 Klk6 Therapeutic antibody target
Klk7-KO NM-KO-200317 Klk7 Therapeutic antibody target
Klk8-KO NM-KO-200318 Klk8 Therapeutic antibody target
Klk9-KO NM-KO-200319 Klk9 Therapeutic antibody target
Klrc1-KO NM-KO-190126 Klrc1 Immune-related
Klrg1-KO NM-KO-190103 Klrg1 Immune-related
Klrk1-KO NM-KO-200320 Klrk1 Therapeutic antibody target
KLRK1-HU NM-HU-190005 Klrk1 Immune-related
Kmt2a-CKO NM-CKO-190028 Kmt2a Epigenetic
Kmt2b-CKO NM-CKO-190029 Kmt2b Epigenetic
Kmt2d-CKO NM-CKO-190030 Kmt2d Epigenetic
Kng1-KO NM-KO-190980 Kng1 Coagulation, thrombosis/thrombosis; tumor, glioma,
Kpna2-KO NM-KO-190308 Kpna2 Immune-related
Kras-(LSL-G12D) NM-KI-190003 Kras cancer research
Kremen1-KO NM-KO-190698 Kremen1 Modulates canonical WNT signaling
Kremen2-KO NM-KO-200321 Kremen2 Therapeutic antibody target
Krt14-(2A-DreERT2) NM-KI-190125 Krt14 Dre tool mouse
Krt14-(CreERT2) NM-KI-190024 Krt14 Cre recombinase tool
Krt14-KO NM-KO-00072 Krt14 skin
Krt5-(2A-CreERT2) NM-KI-190016 Krt5 Cre recombinase tool
Kynu-CKO NM-CKO-00059 Kynu
L1cam-KO NM-KO-200322 L1cam Therapeutic antibody target
LAG3&CTLA4-HU NM-HU-190018 Lag3，Ctla4 Immune-related
Lag3-KO NM-KO-18048 Lag3
LAG3-HU NM-HU-00049 Lag3 Immunotherapy,cancer research,drug screening
LAIR1-HU NM-HU-2000011 Lair1 Immunotherapy,cancer research,drug screening
Lair1-KO NM-KO-200323 Lair1 Therapeutic antibody target
Lama4-KO NM-KO-200324 Lama4 Therapeutic antibody target
Lamb1-KO NM-KO-200325 Lamb1 Therapeutic antibody target
Lamp1-KO NM-KO-200326 Lamp1 Therapeutic antibody target
Lamp5-KO NM-KO-200327 Lamp5 Therapeutic antibody target
Lamtor3-KO NM-KO-200328 Lamtor3 Therapeutic antibody target
Lap3-KO NM-KO-190104 Lap3 Immune-related
Layn-KO NM-KO-190105 Layn Immune-related
Lcat-KO NM-KO-200329 Lcat Therapeutic antibody target
Lck-KO NM-KO-190722 Lck Immune related
Lcn2-CKO NM-CKO-00134 Lcn2
Lcn6-CKO NM-CKO-00109 Lcn6 Androgen Insensitivity Syndrome（AIS）,Obesity，Diabetes Mellitus,Noninsulin-Dependent（NIDDM）,Prostate Cancer
Lcp1-KO NM-KO-200330 Lcp1 Therapeutic antibody target
Ldlr-KO NM-KO-190559 Ldlr Cardiovascular research; lipid metabolism related research
Ldlr-(T541C) NM-KI-00043 Ldlr Metabolic and cardiovascular disease research
Ldlr-KO NM-KO-00102 Ldlr Cardiovascular research; lipid metabolism related research
Leap2-KO NM-KO-200331 Leap2 Therapeutic antibody target
Lep-KO NM-KO-00034 Lep Insulin resistance,obesity,and type 2 diabetes etc.
Lepr-KO NM-KO-190663 Lepr obesity
Lepr-(109052G>T) NM-KI-00001 Lepr Leptin resistance,insulin resistance,obesity,and type 2 diabetes etc.
Lgals1-KO NM-KO-190106 Lgals1 Immune-related
Lgals3-KO NM-KO-190107 Lgals3 Immune-related
Lgals3bp-KO NM-KO-190309 Lgals3bp Immune-related
Lgals9-KO NM-KO-200332 Lgals9 Therapeutic antibody target
Lgmn-CKO NM-CKO-00103 Lgmn cardiovascular system，nervous system，Developmental Biology
Lgr6-KO NM-KO-200333 Lgr6 Therapeutic antibody target
Lhcgr-KO NM-KO-200334 Lhcgr Therapeutic antibody target
Lif-KO NM-KO-190108 Lif Immune-related
Limd1-KO NM-KO-190981 Limd1 Osteoclasts
Lingo1-KO NM-KO-200335 Lingo1 Therapeutic antibody target
Lix1l-KO NM-KO-190982 Lix1l RNA binding protein, tumor
Llgl2-KO NM-KO-190983 Llgl2 Proper polarization invasion and effective branch morphogenesis during placental development
Lmln-KO NM-KO-200336 Lmln Therapeutic antibody target
Lor-KO NM-KO-190109 Lor Immune-related
Loxl4-KO NM-KO-200337 Loxl4 Therapeutic antibody target
Lpar2-KO NM-KO-200338 Lpar2 Therapeutic antibody target
Lpar4-KO NM-KO-200339 Lpar4 Therapeutic antibody target
Lpo-KO NM-KO-190110 Lpo Immune-related
Lpp-KO NM-KO-190984 Lpp Tumor growth, female fertility
Lrat-(2A-Cre) NM-KI-190097 Lrat Cre recombinase tool
Lrg1-KO NM-KO-200340 Lrg1 Therapeutic antibody target
Lrp10-KO NM-KO-190905 Lrp10 uptake of apolipoprotein E-containing lipoproteins，alpha-synucleinopathies, Ingestion of apolipoprotein E, alpha-synucleinopathy
Lrp5-KO NM-KO-190683 Lrp5 Negative regulator of the Wnt-beta-catenin-Tcf signaling pathway.
Lrp8-KO NM-KO-190830 Lrp8 Beta-amyloid metabolism related;Alzheimer's disease research related
Lrrc32-KO NM-KO-190111 Lrrc32 Immune-related
Lrrk2-KO NM-KO-190985 Lrrk2 Parkinson disease-8
Lrrn1-KO NM-KO-200341 Lrrn1 Therapeutic antibody target
Lsm5-KO NM-KO-190831 Lsm5 RNA Binding, aging related.
Lta-KO NM-KO-190542 Lta lymphatic system;leprosy type 4, myocardial infarction, non-Hodgkin's lymphoma, and psoriatic arthritis and other related diseases
Ltb-KO NM-KO-190543 Ltb inflammatory response system
Ltb4r1-KO NM-KO-190832 Ltb4r1 Asthma related
Ltb4r2-KO NM-KO-190310 Ltb4r2 Immune-related
Ltbr-KO NM-KO-200342 Ltbr Therapeutic antibody target
Ltf-CKO NM-CKO-00042 Ltf
Ltk-KO NM-KO-200343 Ltk Therapeutic antibody target
Lum-KO NM-KO-190112 Lum Immune-related
Ly6a-(2A-iCre) NM-KI-190028 Ly6a Cre recombinase tool
Ly6g-(2A-DreERT2） NM-KI-190036 Ly6g Dre recombinase tool
Ly6h-KO NM-KO-200344 Ly6h Therapeutic antibody target
Ly75-KO NM-KO-200345 Ly75 Therapeutic antibody target
Ly9-KO NM-KO-200346 Ly9 Therapeutic antibody target
Lyar-KO NM-KO-190311 Lyar Immune-related
Lyar-CKO NM-CKO-00032 Lyar
Lyg1-KO NM-KO-00017 Lyg1
Lyl1-KO NM-KO-190113 Lyl1 Immune-related
Lyn-KO NM-KO-190833 Lyn Cytokine Receptors，Dendritic Cell Differentiation related.
Lypd3-KO NM-KO-200347 Lypd3 Therapeutic antibody target
Lyz1-(2A-DreERT2） NM-KI-190033 Lyz1 Dre recombinase tool
Lyz2-(IRES-mtagBFP-Akaluc) NM-KI-200029 Lyz2 Monocyte macrophage reporter
Lyz2-(IRES-DTREGFP） NM-KI-190041 Lyz2 DTR mouse
Lyz2-(CreERT2-EGFP) NM-KI-18047 Lyz2 Cre recombinase activity in myeloid cells
Lyz2-(2A-CreERT2-WPRE-pA) NM-KI-18018 Lyz2 Cre recombinase tool
Lyzl4-KO NM-KO-00006 Lyzl4 Reproductive system related research
H11-(CAG-LSL-M2rtTA-FRT-IRES-tdtomato-FRT) NM-KI-190064 M2rtTA tetracycline,M2rtTA mice
Macrod2-CKO NM-CKO-190058 Macrod2 Cancer
Madcam1-KO NM-KO-200348 Madcam1 Therapeutic antibody target
Mag-KO NM-KO-191126 Mag Nervous system, CNS myelination
Magea3-KO NM-KO-200349 Magea3 Therapeutic antibody target
Magea4-KO NM-KO-200350 Magea4 Therapeutic antibody target
Magea6-KO NM-KO-200351 Magea6 Therapeutic antibody target
Mal-KO NM-KO-00037 Mal nervous system
R26-(CAG-LSL-mCherry-EGFP-LC3-pA) NM-KI-00124 Map1lc3a
Map2-KO NM-KO-190834 Map2 Cytoskeleton Regulators
Map2-(CreERT2) NM-KI-00037 Map2 Cre recombinase tool of mature neurons,nervous system
Map2k6-KO NM-KO-190835 Map2k6 Stress Responses,Apoptosis related
Map3k10-KO NM-KO-190986 Map3k10 Nerve growth factor (NGF)-induced neuronal apoptosis
Map3k14-KO NM-KO-200352 Map3k14 Therapeutic antibody target
Map3k9-KO NM-KO-190317 Map3k9 Immune-related
Mapk10-KO NM-KO-190987 Mapk10 Nervous system, epilepsy, Parkinson's disease
Mapk3-KO NM-KO-191093 Mapk3 Cell proliferation, differentiation and cell cycle progression; immune system, T cells; cancer, liver cancer, glioma
Mapk8-KO NM-KO-190836 Mapk8 Signal Transduction, Diabetes related
Mapk9-KO NM-KO-190988 Mapk9 Immune system,T cell function
Mapt-KO NM-KO-190837 Mapt Cytoskeleton Regulators, Apoptosis related.
Masp1-KO NM-KO-200353 Masp1 Therapeutic antibody target
Masp2-KO NM-KO-200354 Masp2 Therapeutic antibody target
Matn3-KO NM-KO-200355 Matn3 Therapeutic antibody target
Mavs-KO NM-KO-190198 Mavs Immune-related
Maz-KO NM-KO-200356 Maz Therapeutic antibody target
Mbd1-CKO NM-CKO-190031 Mbd1 Epigenetic
Mbd2-KO NM-KO-190114 Mbd2 Immune-related
Mbd3-CKO NM-CKO-190049 Mbd3 Epigenetic
Mbd5-CKO NM-CKO-00035 Mbd5
Mbp-KO NM-KO-190115 Mbp Immune-related
Mc3r-KO NM-KO-190652 Mc3r obesity
Mc4r-KO NM-KO-200357 Mc4r Therapeutic antibody target
Mcam-KO NM-KO-190312 Mcam Immune-related
Mchr1-KO NM-KO-190638 Mchr1 nervous system
Mcoln3-KO NM-KO-200358 Mcoln3 Therapeutic antibody target
Mcpt8-(CreERT2) NM-KI-200006 Mcpt8 Cre recombinase tool
Mdk-KO NM-KO-200359 Mdk Therapeutic antibody target
Mdm4-(C462A) NM-KI-00007 Mdm4
Mecp2-CKO NM-CKO-190001 Mecp2 Rett syndrome, autism
Megf9-KO NM-KO-190313 Megf9 Immune-related
Melk-KO NM-KO-200360 Melk Therapeutic antibody target
Meltf-KO NM-KO-200361 Meltf Therapeutic antibody target
Mertk-KO NM-KO-200362 Mertk Therapeutic antibody target
Mettl14-CKO NM-CKO-190007 Mettl14 Epigenetic
Mettl16-KO NM-KO-190314 Mettl16 Immune-related
Mettl21a-KO NM-KO-190315 Mettl21a Immune-related
R26-(CAG-LSL-3xFLAG-Mettl3-IRES-EGFP) NM-KI-190056 Mettl3 mRNA methylation
Mfap4-KO NM-KO-200363 Mfap4 Therapeutic antibody target
Mfge8-KO NM-KO-200364 Mfge8 Therapeutic antibody target
Mfsd13a-KO NM-KO-200365 Mfsd13a Therapeutic antibody target
Mgmt-KO NM-KO-190625 Mgmt colorectal cancer, lung cancer, lymphoma and glioblastoma
Mid1-KO NM-KO-190316 Mid1 Immune-related
Mif-KO NM-KO-200366 Mif Therapeutic antibody target
Mill2-KO NM-KO-200367 Mill2 Therapeutic antibody target
Mip-KO NM-KO-190116 Mip Immune-related
Mir125a-KO NM-KO-00040 Mir125a
Mir126-CKO NM-CKO-00030 Mir126
Mir21a-KO NM-KO-00159 Mir21a microRNA
Mir21a-CKO NM-CKO-00051 Mir21a
Mir29a-Mir29b1-KO NM-KO-00081 Mir29a，Mir29b-1 microRNA,mir29 gene function study
Mir29b2-Mir29c-KO NM-KO-00080 Mir29b-2，Mir29c microRNA,Mir29 gene function study
Mirc34-KO NM-KO-00164 Mir449a，Mir449b，Mir449c microRNA
Mlana-KO NM-KO-200368 Mlana Therapeutic antibody target
Mlc1-KO NM-KO-190117 Mlc1 Immune-related
Mlh1-KO NM-KO-190626 Mlh1 hereditary nonpolyposis colon cancer (HNPCC)
Mme-KO NM-KO-200369 Mme Therapeutic antibody target
Mmp12-KO NM-KO-200370 Mmp12 Therapeutic antibody target
Mmp13-KO NM-KO-200371 Mmp13 Therapeutic antibody target
Mmp3-KO NM-KO-200372 Mmp3 Therapeutic antibody target
Mmp7-KO NM-KO-190699 Mmp7 Cancer-related genes
Mmp8-KO NM-KO-200373 Mmp8 Therapeutic antibody target
Mmp9-KO NM-KO-190838 Mmp9 Asthma related
Mnx1-(CreERT2) NM-KI-200009 Mnx1 Cre recombinase tool
Mnx1-(Cre) NM-KI-200010 Mnx1 Cre recombinase tool
Mob1a-CKO NM-CKO-200004 Mob1a Hippo signaling pathway and cancer related
Mob1b-CKO NM-CKO-200005 Mob1b Hippo signaling pathway and cancer related
Mog-KO NM-KO-190118 Mog Immune-related
Mos-KO NM-KO-190616 Mos MOS is a serine/threonine kinase that activates the MAP kinase cascade through direct phosphorylation of the MAP kinase activator MEK (MAP2K1; MIM 176872)
Mpdz-KO NM-KO-190989 Mpdz Nervous system, alcohol dependence, congenital hydrocephalus disease
Mptx1-KO NM-KO-190318 Mptx1 Immune-related
Mpzl2-KO NM-KO-200374 Mpzl2 Therapeutic antibody target
Mr1-KO NM-KO-190119 Mr1 Immune-related
Mrc1-KO NM-KO-190228 Mrc1 Immune-related
Mrc2-KO NM-KO-190216 Mrc2 Immune-related
Mreg-KO NM-KO-190121 Mreg Immune-related
Mrgprf-KO NM-KO-00050 Mrgprf
CD20-HU NM-HU-190068 Ms4a1 Immunotherapy,cancer research,drug screening
Ms4a1-KO NM-KO-190732 Ms4a1 Immune related. The development and differentiation of B-cells into plasma cells research.
Ms4a2-KO NM-KO-190839 Ms4a2 Mast Cells, Allergy and Asthma related.
Msln-KO NM-KO-200375 Msln Therapeutic antibody target
Msmb-KO NM-KO-200376 Msmb Therapeutic antibody target
Mst1-KO NM-KO-190990 Mst1 Hepatocyte, nonalcoholic steatohepatitis
Mst1r-KO NM-KO-200377 Mst1r Therapeutic antibody target
Mstn-KO NM-KO-190535 Mstn Growth Factors，skeletal muscle cell proliferation and differentiation。
Mt1-KO NM-KO-00161 Mt1 Antioxidation, intracellular metal homeostasis, oxidative stress
Mterf1a-KO NM-KO-190840 Mterf1a
Mtfp1-KO NM-KO-190706 Mtfp1 A mitochondrial protein,which plays a role in cell viability and mitochondrial dynamics.
Mtnr1b-KO NM-KO-190319 Mtnr1b Immune-related
Mtrex-KO NM-KO-190370 Mtrex Immune-related
Mtss1-KO NM-KO-190707 Mtss1 Synaptic function and neurodegeneration related.
Muc1-KO NM-KO-190120 Muc1 Immune-related
Muc1-CKO NM-CKO-00061 Muc1
Muc13-KO NM-KO-200378 Muc13 Therapeutic antibody target
Muc16-KO NM-KO-200379 Muc16 Therapeutic antibody target
Muc4-KO NM-KO-200380 Muc4 Therapeutic antibody target
Muc5ac-KO NM-KO-190841 Muc5ac Asthma related
Mxd4-KO NM-KO-190320 Mxd4 Immune-related
Mxi1-KO NM-KO-191084 Mxi1 Tumor research; spleen, benign prostatic hyperplasia, renal degenerative disease
Mxra8-KO NM-KO-200381 Mxra8 Therapeutic antibody target
Myb-KO NM-KO-190617 Myb This gene encodes a protein with three HTH DNA-binding domains that functions as a transcription regulator. This protein plays an essential role in the regulation of hematopoiesis. This gene may be aberrently expressed or rearranged or undergo translocation in leukemias and lymphomas, and is considered to be an oncogene.
H11-(Myc) NM-KI-00039 Myc tumor-bearing model,cancer research
H11-(CAG-LSL-HA tag-Nmyc-IRES-EGFP) NM-KI-190084 Mycn cancer research
Mycn-(TRE-EGFP) NM-KI-00008 Mycn cancer research, nervous system research
Myd88-KO NM-KO-190192 Myd88 Immune-related
Mydgf-CKO NM-CKO-00021 Mydgf
Myh11-(2A-DreERT2） NM-KI-190037 Myh11 Dre recombinase tool
Myh14-KO NM-KO-200382 Myh14 Therapeutic antibody target
Myh6-(Cre) NM-KI-00083 Myh6 Cre recombinase tool of heart
Myl9-KO NM-KO-200383 Myl9 Therapeutic antibody target
Mylk2-KO NM-KO-190991 Mylk2 Calcium/calmodulin-dependent enzyme, skeletal muscle
Myo1c-KO NM-KO-191120 Myo1c Intracellular vesicle transport, hematopoietic system
Myo6-KO NM-KO-200384 Myo6 Therapeutic antibody target
Myom2-KO NM-KO-190321 Myom2 Immune-related
Naa20-KO NM-KO-190322 Naa20 Immune-related
Naalad2-KO NM-KO-00039 Naalad2
Nae1-KO NM-KO-190842 Nae1 Apoptosis, Cell Cycle,Alzheimer's disease research related
Naip1-KO NM-KO-190203 Naip1 Immune-related
Nav2-KO NM-KO-190708 Nav2 Nervous System related
Ncam1-KO NM-KO-200385 Ncam1 Therapeutic antibody target
Ncam2-KO NM-KO-200386 Ncam2 Therapeutic antibody target
Ncapg-KO NM-KO-190323 Ncapg Immune-related
Ncf1-KO NM-KO-190123 Ncf1 Immune-related
Nck1-KO NM-KO-190723 Nck1 Cancer related
Ncl-KO NM-KO-200387 Ncl Therapeutic antibody target
Ncoa1-KO NM-KO-190992 Ncoa1 Endocrine and metabolism, bone remodeling and the effects of sex hormones on bones, obesity; nervous system, Purkinje cell development
Ncoa2-CKO NM-CKO-190032 Ncoa2 Epigenetic
Ncoa3-CKO NM-CKO-190033 Ncoa3 Epigenetic
Ncr1-(IRES-mtagBFP-Akaluc) NM-KI-200030 Ncr1 NK cell reporter
Ncr1-(CreERT2) NM-KI-200004 Ncr1 Cre recombinase tool
Ncr1-KO NM-KO-200388 Ncr1 Therapeutic antibody target
Ncr1-(2A-iCre） NM-KI-190027 Ncr1 Cre recombinase tool
Ncr1-(IRES-DTREGFP） NM-KI-190044 Ncr1 DTR mouse
Ndrg1-KO NM-KO-191071 Ndrg1 Stress response, hormonal response, cell growth and differentiation; peripheral nerve demyelinating disease; cancer
Ndufb11-KO NM-KO-190843 Ndufb11 Aging, Mitochondrial Dysfunction,
Ndufs7-KO NM-KO-190324 Ndufs7 Immune-related
Nectin2-KO NM-KO-200389 Nectin2 Therapeutic antibody target
Nectin4-KO NM-KO-200390 Nectin4 Therapeutic antibody target
Nfatc2-KO NM-KO-190124 Nfatc2 Immune-related
Nfe2l2-KO NM-KO-190433 Nfe2l2 transcription factor
R26-(CAG-LSL-NFE2L2(G81S)-IRES-Luciferase-2A-tdTomato) NM-KI-190077 NFE2L2 cancer research
Nfil3-KO NM-KO-190125 Nfil3 Immune-related
Nfkb1-KO NM-KO-190844 Nfkb1 Transcription Factors,T cell function,immune system
Tg(Nfkb2 pro-Luc) NM-TG-190003 Nfkb2 Tool Mice
Nfkbib-KO NM-KO-200391 Nfkbib Therapeutic antibody target
R26-(CAG-LSL-NgAgo-IRES-EGFP-WPRE-pA) NM-KI-18011 NgAgo
Ngef-KO NM-KO-190993 Ngef Retinal ganglion cell
Ngf-KO NM-KO-191166 Ngf Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis.
Nhlh2-KO NM-KO-190713 Nhlh2 May serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system.
Nipbl-CKO NM-CKO-00067 Nipbl nervous system
Nkd1-KO NM-KO-190684 Nkd1 Bone density related diseases
Nkg7-KO NM-KO-190127 Nkg7 Immune-related
Nkx3-1-(CreERT2) NM-KI-18036 Nkx3-1 Cre recombinase tool
Nlrc3-KO NM-KO-190220 Nlrc3 Immune-related
Nlrc4-KO NM-KO-190226 Nlrc4 Immune-related
Nlrc5-KO NM-KO-00042 Nlrc5 immune system
Nlrp10-KO NM-KO-190199 Nlrp10 Immune-related
Nlrp12-KO NM-KO-190200 Nlrp12 Immune-related
Nlrp14-KO NM-KO-190201 Nlrp14 Immune-related
Nlrp1a-KO NM-KO-190227 Nlrp1a Immune-related
Nlrp2-KO NM-KO-190206 Nlrp2 Immune-related
Nlrp3-CKO NM-CKO-190002 Nlrp3 Immune-related
Nlrp3-KO NM-KO-190428 Nlrp3 Immune-related
Nlrp3-KO NM-KO-190230 Nlrp3 Immune-related
Nlrp4c-KO NM-KO-190207 Nlrp4c Immune-related
Nlrp4e-KO NM-KO-190325 Nlrp4e Immune-related
Nlrp5-KO NM-KO-190209 Nlrp5 Immune-related
Nlrp6-KO NM-KO-190211 Nlrp6 Immune-related
Nmb-KO NM-KO-190653 Nmb hunger, weight gain and obesity
Nmbr-KO NM-KO-190654 Nmbr hunger, weight gain and obesity
Nme7-KO NM-KO-200392 Nme7 Therapeutic antibody target
Nmu-KO NM-KO-190326 Nmu Immune-related
Nmur1-KO NM-KO-190650 Nmur1 cardiovascular
Nod1-KO NM-KO-190208 Nod1 Immune-related
Nod2-KO NM-KO-190210 Nod2 Immune-related
Nodal-KO NM-KO-190536 Nodal Growth Factors，early embryonic development.
Nono-KO NM-KO-200393 Nono Therapeutic antibody target
Nos2-KO NM-KO-18027 Nos2 inflammatory
Nos3-KO NM-KO-18022 Nos3
Nosip-KO NM-KO-190994 Nosip Nitric oxide production
Nostrin-KO NM-KO-190995 Nostrin Angiogenesis, endothelial cell migration
Notch3-KO NM-KO-190129 Notch3 Immune-related
Notch4-KO NM-KO-200394 Notch4 Therapeutic antibody target
Notum-KO NM-KO-200395 Notum Therapeutic antibody target
Nox1-KO NM-KO-191172 Nox1
Nox4-KO NM-KO-191173 Nox4 The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth.
Npb-KO NM-KO-190130 Npb Immune-related
Npc1-(I1060T) NM-KI-18059 Npc1
Npffr2-KO NM-KO-190327 Npffr2 Immune-related
Nphp4-KO NM-KO-190996 Nphp4 Vision, retinopathy, photoreceptor cell degeneration; oligozoospermia, male sterility
Nphs2-CreERT2 NM-KI-00128 Nphs2
Nppb-KO NM-KO-190997 Nppb Fibrotic ventricular lesion
Nppc-KO NM-KO-190998 Nppc Endochondral ossification
Npr3-(2A-DreERT2) NM-KI-190015 Npr3 Dre recombinase tool
Npw-KO NM-KO-200396 Npw Therapeutic antibody target
Npy-KO NM-KO-190641 Npy metabolic and cardiovascular diseases
Npy1r-KO NM-KO-190999 Npy1r Endocrine and metabolic, obesity, hyperinsulinemia; nervous system, pain
Npy2r-KO NM-KO-190601 Npy2r
Npy5r-KO NM-KO-190602 Npy5r The protein encoded by this gene is a receptor for neuropeptide Y and peptide YY. The encoded protein appears to be involved in regulating food intake, with defects in this gene being associated with eating disorders. Also, the encoded protein is involved in a pathway that protects neuroblastoma cells from chemotherapy-induced cell death, providing a possible therapeutic target against neuroblastoma.
Nqo1-KO NM-KO-190845 Nqo1 Apoptosis, Endocrine, fat metabolism, apoptosis
Nr1h4-KO NM-KO-190328 Nr1h4 Immune-related
Nr1i2-KO NM-KO-200397 Nr1i2 Therapeutic antibody target
Nr2c1-KO NM-KO-200398 Nr2c1 Therapeutic antibody target
Nr2e1-KO NM-KO-00163 Nr2e1
Nr6a1-CKO NM-CKO-00054 Nr6a1
Nras-KO NM-KO-190618 Nras This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia.
Nrip2-KO NM-KO-190329 Nrip2 Immune-related
Nsd1-CKO NM-CKO-190050 Nsd1 Epigenetic
Nsf-KO NM-KO-190846 Nsf Diabetes, Receptors, Transporters & Channels,
Nsg1-KO NM-KO-191000 Nsg1 Apoptosis, receptor endocytosis, recycling
NT5E-HU NM-HU-200009 Nt5e Immunotherapy,cancer research,drug screening
Nt5e-KO NM-KO-200399 Nt5e Therapeutic antibody target
Ntrk2-KO NM-KO-191001 Ntrk2 Nervous system, follicle formation
Nts-KO NM-KO-190655 Nts nervous system
Ntsr1-KO NM-KO-190656 Ntsr1 nervous system
Ntsr2-KO NM-KO-190611 Ntsr2 The protein encoded by this gene belongs to the G protein-coupled receptor family that activate a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds neurotensin as well as several other ligands already described for neurotensin NT1 receptor.
Nucb2-KO NM-KO-200400 Nucb2 Therapeutic antibody target
OCLN-HU NM-HU-190072 Ocln HCV infection research
Olfml3-KO NM-KO-200401 Olfml3 Therapeutic antibody target
Olfr1404-KO NM-KO-191145 Olfr1404 Olfactory research related
Olr1-KO NM-KO-190330 Olr1 Immune-related
Oosp1-KO NM-KO-00030 Oosp1
Oprk1-KO NM-KO-190642 Oprk1 alcohol dependence and opiate addiction
Oprm1-KO NM-KO-190643 Oprm1 dopamine system
Orai1-KO NM-KO-190131 Orai1 Immune-related
Osbpl2-KO NM-KO-190331 Osbpl2 Immune-related
Oscar-KO NM-KO-200402 Oscar Therapeutic antibody target
Osm-KO NM-KO-190537 Osm Growth Factors,leukemia.
Osmr-KO NM-KO-200403 Osmr Therapeutic antibody target
Otub2-KO NM-KO-190332 Otub2 Immune-related
Otud3-KO NM-KO-190333 Otud3 Immune-related
Oxtr-KO NM-KO-190612 Oxtr The protein encoded by this gene belongs to the G-protein coupled receptor family and acts as a receptor for oxytocin. Its activity is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. The oxytocin-oxytocin receptor system plays an important role in the uterus during parturition.
P2rx4-KO NM-KO-191002 P2rx4 Hypertension, NO homeostasis, vascular remodeling, vasodilation
P2rx7-KO NM-KO-200404 P2rx7 Therapeutic antibody target
P4hb-KO NM-KO-191065 P4hb Immune system, neutrophils; cancer, colon cancer, liver cancer, gastric cancer, diffuse glioma
Pacsin1-KO NM-KO-191003 Pacsin1 Nervous system, synaptic vesicle formation, synaptic transmission, neural network activity
Padi2-KO NM-KO-200405 Padi2 Therapeutic antibody target
Padi4-KO NM-KO-190334 Padi4 Immune-related
Pag1-KO NM-KO-200406 Pag1 Therapeutic antibody target
Palld-KO NM-KO-00009 Palld Research on embryonic development, nervous system, hematopoietic system, etc.
Panx1-KO NM-KO-190847 Panx1 Inflammatory Response，macrophage， retinal ganglion cell ，, Inflammatory response, macrophages, nervous system, optic ganglion cells
Pappa-KO NM-KO-190132 Pappa Immune-related
Paqr4-KO NM-KO-00044 Paqr4
Paqr4-CKO NM-CKO-00069 Paqr4
Paqr9-KO NM-KO-00062 Paqr9
Pard6g-KO NM-KO-191004 Pard6g Epithelial cell proliferation regulation, trabecular formation in neonatal hearts
Park2-KO NM-KO-191005 Park2 Parkinson disease and autosomal recessive juvenile Parkinson disease
Park7-KO NM-KO-191006 Park7 a sensor for oxidative stress, autosomal recessive early-onset Parkinson disease 7
Parp1-KO NM-KO-190848 Parp1 Diabetes, Metabolic Enzymes, Auditory, neurotoxicity, renal ischemic injury
Parp2-KO NM-KO-191146 Parp2
Pax4-KO NM-KO-190849 Pax4 Transcription Factors, Insulin and somatostatin secretion
Pax7-(2A-DreERT2) NM-KI-190124 Pax7 Dre tool mouse
Pcbp2-KO NM-KO-190336 Pcbp2 Immune-related
Pcdha3-KO NM-KO-200407 Pcdha3 Therapeutic antibody target
Pcsk9-KO NM-KO-200408 Pcsk9 Therapeutic antibody target
PCSK9-HU NM-HU-00075 Pcsk9 Immunotherapy,cancer research,drug screening
PD-1-HU NM-HU-190079 PD1 Immunotherapy,cancer research,drug screening
Pdap1-KO NM-KO-190337 Pdap1 Immune-related
Pdc-KO NM-KO-190133 Pdc Immune-related
PD-1&PD-L1&PD-L2-HU NM-HU-190060 Pdcd1， Cd274， Pdcd1lg2 Immunotherapy,cancer research,drug screening
PD-1&SEMA4D-HU NM-HU-190033 Pdcd1，Sema4d Immunotherapy,cancer research,drug screening
PD-1&CD40-HU NM-HU-190017 Pdcd1，Cd40 Immune-related
PD-1&SIRPA-HU NM-HU-190022 Pdcd1，Sirpa Immune-related
PD-1&TLR9-HU NM-HU-190023 Pdcd1，Tlr9 Immune-related
PD-1&PD-L1&LAG3-HU NM-HU-190028 Pdcd1，Cd274，Lag3 Immune-related
PD-1&GITR-HU NM-HU-190014 Pdcd1，Tnfrsf18 Immune-related
PD-1&TIGIT&TIM3-HU NM-HU-190029 Pdcd1，Tigit，Havcr2 Immune-related
Pdcd1-KO NM-KO-190423 Pdcd1 Immune-related
PD-1&CD3e-HU NM-HU-18021 Pdcd1，Cd3e Immunotherapy,cancer research,drug screening
PD-1&PD-L1-HU NM-HU-00100 Pdcd1，Cd274 Immunotherapy,cancer research,drug screening
PD-1&TIM3-HU NM-HU-00103 Pdcd1，Havcr2 Immunotherapy,cancer research,drug screening
PD-1&LAG3-HU NM-HU-00101 Pdcd1，Lag3 Immunotherapy,cancer research,drug screening
PD-1&TIGIT-HU NM-HU-00104 Pdcd1，Tigit Immunotherapy,cancer research,drug screening
PD-1&OX40-HU NM-HU-00108 Pdcd1，Tnfrsf4 cancer research,Immunotherapy,drug screening
PD-1&CTLA4-HU NM-HU-00079 Pdcd1，Ctla4 cancer research,Immunotherapy,drug screening
PD-1-HU NM-HU-00015 Pdcd1 Immunotherapy,cancer research,drug screening
Pdcd10-CKO NM-CKO-00079 Pdcd10
Pdcd1lg2-KO NM-KO-190728 Pdcd1lg2 These mice may be useful for studying self tolerance, Th1 and Th2 immune responses.
PD-L2-HU NM-HU-190061 Pdcd1lg2 Immunotherapy,cancer research,drug screening
PD-L2-HU NM-HU-190050 Pdcd1lg2 Immunotherapy,cancer research,drug screening
Pdcd6-KO NM-KO-190850 Pdcd6 Apoptosis,
Pde3a-KO NM-KO-191007 Pde3a Cardiovascular system, platelet aggregation, vascular smooth muscle relaxation, congestive heart failure, oocyte development, female sterility
Pde3b-KO NM-KO-191008 Pde3b Lipid metabolism, energy metabolism, obesity
Pde5a-KO NM-KO-191009 Pde5a Cardiovascular system, vascular smooth muscle cells, tumor
Pde7a-KO NM-KO-190134 Pde7a Immune-related
Pdgfd-KO NM-KO-190338 Pdgfd Immune-related
Pdk1-KO NM-KO-191074 Pdk1 Mitochondrial multienzyme complex, cancer
Pdx1-(Avi-CreERT2) NM-KI-18042 Pdx1
Pecam1-KO NM-KO-190339 Pecam1 Immune-related
Per1-KO NM-KO-191063 Per1 Nervous system, circadian rhythm; tumor
Pf4-KO NM-KO-190135 Pf4 Immune-related
Pfkfb4-KO NM-KO-191075 Pfkfb4 Cancer, small cell lung cancer, melanoma, colon cancer
Pfkl-KO NM-KO-191076 Pfkl Glucose metabolism (glycolysis)
Pfkp-KO NM-KO-191187 Pfkp Glycolysis, cancer, clear cell renal cell carcinoma and bladder cancer, breast cancer and lung cancer
Pfkp-KO NM-KO-190555 Pfkp Glycolysis regulation, metabolism and cancer research
Pgam5-KO NM-KO-190340 Pgam5 Immune-related
Pgf-KO NM-KO-191069 Pgf Growth factor, angiogenesis
Pgk1-KO NM-KO-191010 Pgk1 Glycolysis enzyme, tumor, hemolytic anemia, neurological dysfunction
Pglyrp1-KO NM-KO-200409 Pglyrp1 Therapeutic antibody target
Pgp-KO NM-KO-190136 Pgp Immune-related
Phf3-KO NM-KO-190851 Phf3 Transcriptional Regulation,
Phf6-KO NM-KO-190341 Phf6 Immune-related
Pi16-KO NM-KO-200410 Pi16 Therapeutic antibody target
Pias2-KO NM-KO-190342 Pias2 Immune-related
Pidd1-KO NM-KO-191165 Pidd1 The expression of the mouse counterpart of this gene has been found to be positively regulated by the tumor suppressor p53 and to induce cell apoptosis in response to DNA damage, which suggests a role for this gene as an effector of p53-dependent apoptosis.
Piezo1-(CreERT2) NM-KI-18048 Piezo1 Mechanically sensitive ion channel Cre tool mouse
Piezo2-KO NM-KO-190343 Piezo2 Immune-related
Pik3c2a-KO NM-KO-190632 Pik3c2a hematopoietic,immune,
R26-(CAG-LSL-PIK3CA(H1047R)-IRES-luciferase-2A-tdTomato) NM-KI-190065 PIK3CA cancer research
Pik3cd-KO NM-KO-190852 Pik3cd Signal Transduction, T cell B cell antibody receptor signal transduction, inflammatory bowel disease, immune system
Pik3cg-KO NM-KO-191094 Pik3cg Immune system, thymocyte development, T cells, neutrophils; cancer
Pim1-KO NM-KO-191080 Pim1 Blood system, red blood cells; cancer, hematopoietic malignancies, prostate cancer
Pink1-KO NM-KO-191011 Pink1 mitochondrial homeostasis, autosomal recessive early-onset Parkinson disease
Pkp4-KO NM-KO-190853 Pkp4 Cytoskeleton Regulators,
Pla2g1b-KO NM-KO-200411 Pla2g1b Therapeutic antibody target
Pla2g2a-KO NM-KO-200412 Pla2g2a Therapeutic antibody target
Pla2g6-KO NM-KO-200413 Pla2g6 Therapeutic antibody target
Pla2r1-KO NM-KO-200414 Pla2r1 Therapeutic antibody target
Plat-KO NM-KO-190854 Plat Alzheimer's Disease , Beta-Amyloid Generation, Oligomerization, Clearance & Degradation, Nervous system, behavior, CNS synaptic transmission
Plau-KO NM-KO-190855 Plau Alzheimer's Disease ,Beta-Amyloid Generation, Oligomerization, Clearance & Degradation, immune system,
Plaur-KO NM-KO-200415 Plaur Therapeutic antibody target
Plcb4-KO NM-KO-191012 Plcb4 Nervous system, ataxia, vision, circadian rhythm
Plce1-KO NM-KO-190344 Plce1 Immune-related
Plcg2-KO NM-KO-191013 Plcg2 Immune system, B cell, NK cell function, spontaneous inflammation, antibody deficiency, immune disorder syndrome, familial cold spontaneous inflammation syndrome 3
Pld1-KO NM-KO-191095 Pld1 Signal transduction and subcellular transport; tumor research, angiogenesis, autophagy, platelet function, thrombosis, ischemic brain damage
Pld2-KO NM-KO-191096 Pld2 Cytoskeletal organization, cell cycle control, transcriptional regulation and/or regulation of secretion; nervous system, Alzheimer's disease; tumor
Plin1-(2A-DreERT2） NM-KI-190034 Plin1 Dre recombinase tool
Plod2-KO NM-KO-191014 Plod2 Brooke syndrome
Plxdc2-KO NM-KO-200416 Plxdc2 Therapeutic antibody target
Plxna1-KO NM-KO-200417 Plxna1 Therapeutic antibody target
Plxnb1-KO NM-KO-200418 Plxnb1 Therapeutic antibody target
Pmch-(Pmch(CDS)) NM-KI-190117 Pmch Obesity and insulin resistance research
Pmel-KO NM-KO-190137 Pmel Immune-related
Pml-KO NM-KO-190619 Pml The protein encoded by this gene is a member of the tripartite motif (TRIM) family. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL).
Pnliprp1-KO NM-KO-00005 Pnliprp1 Diabetes and Obesity
R26-(CAG-LSL-PNPLA3(I148M)-EGFP) NM-KI-200013 PNPLA3 rs738409：148 isoleucine to Methionine protein variant,I148M.Non-alcoholic fatty liver and hepatitis B cirrhosis research.
Pnpla3-KO NM-KO-00051 Pnpla3
Podxl2-KO NM-KO-200419 Podxl2 Therapeutic antibody target
Polrmt-KO NM-KO-190856 Polrmt Genomic Instability,Mitochondrial Dysfunction,
Pomc-KO NM-KO-190658 Pomc early onset obesity, adrenal insufficiency, and red hair pigmentation
Ppara-KO NM-KO-190345 Ppara Immune-related
Ppard-CKO NM-CKO-190068 Ppard NASH(nonalcoholic steatohepatitis) research
Pparg-CKO NM-CKO-190071 Pparg Insulin resistance, scarring alopecia, pulmonary arterial hypertension, osteoclastogenesis and milk production (inflammatory milk), and vascular nitric oxide production and endothelial cell dysfunction research.
Ppbp-KO NM-KO-190526 Ppbp Chemokines，DNA synthesis、mitosis、glycolysis、intracellular cAMP accumulation、prostaglandin E2 secretion、and synthesis of hyaluronic acid and sulfated glycosaminoglycan
Ppcs-KO NM-KO-200420 Ppcs Therapeutic antibody target
Ppfia3-KO NM-KO-200421 Ppfia3 Therapeutic antibody target
Ppid-KO NM-KO-191015 Ppid Mitochondrial function,endothelial cell antioxidant
Ppp1r13b-KO NM-KO-190346 Ppp1r13b Immune-related
Ppp2cb-KO NM-KO-191016 Ppp2cb Tumor,cell cycle,viral infection
Ppp2r2b-KO NM-KO-191122 Ppp2r2b Spinocerebellar ataxia 12 (SCA12)
Ppp2r2d-KO NM-KO-191017 Ppp2r2d Tumor
Ppp2r5e-KO NM-KO-190347 Ppp2r5e Immune-related
Ppp3ca-KO NM-KO-191018 Ppp3ca Immune system, T cells; nervous system, epilepsy, neurodevelopmental diseases
Ppp6c-CKO NM-CKO-00115 Ppp6c
Prame-KO NM-KO-200422 Prame Therapeutic antibody target
Prap1-KO NM-KO-200423 Prap1 Therapeutic antibody target
Prcp-KO NM-KO-200424 Prcp Therapeutic antibody target
Prdm1-CKO NM-CKO-190074 Prdm1 Central Nervous System Lymphoma and Adult Lymphoma research
Prdm16-KO NM-KO-200425 Prdm16 Therapeutic antibody target
Prdm2-CKO NM-CKO-190034 Prdm2 Epigenetic
Prdx2-KO NM-KO-191019 Prdx2 Immune system, T cell; blood system, hemolytic anemia; tumor
Prdx6-KO NM-KO-200426 Prdx6 Therapeutic antibody target
Prf1-KO NM-KO-190193 Prf1 Immune-related
Prg2-KO NM-KO-190857 Prg2 Allergy and Asthma,Eosinophils, Eosinophil fine structure changes
Prg3-KO NM-KO-200427 Prg3 Therapeutic antibody target
Prg4-KO NM-KO-200428 Prg4 Therapeutic antibody target
Prkaa1-KO NM-KO-191107 Prkaa1 Cellular energy sensor, metabolism, hematopoiesis
Prkaa2-KO NM-KO-191108 Prkaa2 Cellular energy sensor, metabolism, systemic insulin sensitivity, maintaining myocardial energy homeostasis during ischemia
Prkab2-KO NM-KO-191109 Prkab2 Metabolism,nervous system,sleep disorders,schizophrenia
Prkag1-KO NM-KO-191110 Prkag1 Hematopoietic, hemolytic anemia; cancer
Prkag2-KO NM-KO-191111 Prkag2 Metabolism, obesity, Wolf-Parkinson-White syndrome, familial hypertrophic cardiomyopathy, cardiac glycogen storage
Prkag3-KO NM-KO-191112 Prkag3 Metabolism, skeletal muscle energy metabolism
Prkca-KO NM-KO-190858 Prkca Alzheimer's Disease , Apoptosis,Cell Cycle,Protein Kinases, Cardiomyocyte function
Prkcb-KO NM-KO-190859 Prkcb Alzheimer's Disease,Protein Kinases，Intracellular Signaling, Immune system, B cell function, vascular wound healing
Prkcd-KO NM-KO-190860 Prkcd Alzheimer's Disease，Intracellular Signaling, Immune system, neutrophils, B cells, acute inflammation
Prkce-KO NM-KO-190861 Prkce Alzheimer's Disease，Intracellular Signaling, Acute behavioral studies of the nervous system, alcohol and activated GABA(A) receptor drugs, anxiety and