Foxp3-(V5-Avi tag-IRES-Akaluc-2A-tdTomato)


Strain Information

Strain Name

C57BL/6J-Foxp3em1(V5-Avi-IRES-Akaluc-2A-tdTomato)Smoc

Cat. NO.

NM-KI-18034

Gene Symbol

Foxp3

Gene Synonyms

JM2, scurfin

Human Ortholog

FOXP3

Ensembl ID

MGI ID

NCBI ID


Description

Using CRISPR gene editing technology, a V5-Avi-IRES-Akaluc-2A-tdTomato expression cassette was inserted before the stop codon TGA of mouse Foxp3 gene to establish a multi-labeled knockin model with V5, Avi, Akaluc luciferase and tdTomato fluorescent protein. Akaluc is a novel luciferase that produces up to 1,000 times as bright as light emitted by existing systems by feeding or injecting a synthetic luciferin compound called AkaLumine-HCl, which is better able to penetrate the blood-brain barrier than d-luciferin is.

Research application

gene tracing

Status

Availability

Repository Live


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Milestones

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