CTLA4&4-1BB-HU


Strain Information

Strain Name

C57BL/6J-Ctla4em1(hCTLA4) Tnfrsf9em1(hTNFRSF9) /Smoc

Cat. NO.

NM-HU-18020

Gene Symbol

Ctla4,Tnfrsf9

Gene Synonyms

Cd152, Ly-56, Ctla-4,4-1BB, A930040I11Rik, Cd137, CDw137, ILA, Ly63

Human Ortholog

CTLA4,TNFRSF9

MGI ID

NCBI ID


Description

This CTLA4 and 4-1BB double knockin strain is established by crossing  CTLA4-HU and  4-1BB-HU mice  together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.


Research application

Immunotherapy,cancer research,drug screening

Status

Availability

Repository Live


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Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

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Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

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