PD-L1&4-1BB-HU


Strain Information

Strain Name

C57BL/6J-Cd274em1(hPD-L1)Tnfrsf9em1(hTNFRSF9)/Smoc

Cat. NO.

NM-HU-00138

Gene Symbol

Cd274,Tnfrsf9

Gene Synonyms

B7h1, Pdl1, Pdcd1l1,Pdcd1lg1, A530045L16Rik,4-1BB, A930040I11Rik, Cd137, CDw137, ILA, Ly63

Human Ortholog

CD274,TNFRSF9

MGI ID

NCBI ID


Description

This PD-L1 and 4-1BB double knockin strain is established by crossing PD-L1-HU and 4-1BB-HU mice  together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.


Research application

​Immunotherapy,cancer research,drug screening

Status

Availability

Repository Live


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Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

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Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

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