PD-1&PD-L1&IDO1-HU


Strain Information

Strain Name

C57BL/6-Ido1tm1(hIDO1)Pdcd1em1(hPDCD1)Cd274em1(hPD-L1)/Smoc

Cat. NO.

NM-HU-00120

Gene Symbol

Ido1,Pdcd1,Cd274

Gene Synonyms

Ido, Indo,PD-1, Pdc1, Ly101,B7h1, Pdl1, Pdcd1l1, Pdcd1lg1, A530045L16Rik

Human Ortholog

IDO1,PDCD1,CD274

MGI ID

NCBI ID


Description

This PD1 , IDO-1 and CTLA4 triple knockin strain is established by crossing IDO1-HU, PD1-HU and CTLA4-HU mice of three humanized strains together. These triple double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.


Research application

cancer research,Immunotherapy,drug screening

Status

Availability

Embryo cryopreservation


Related Articles

Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

查看
Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

查看
Contact us Email Gene-editing proposal Gene-editing proposal Back to top Back to top