Lepr-(109052G>T)


Strain Information

Strain Name

B6.129-Leprtm1Smoc

Cat. NO.

NM-KI-00001

Gene Symbol

Lepr

Gene Synonyms

db, Obr, obl, Leprb, Modb1, LEPROT, OB-RGRP, diabetes, obese-like

Human Ortholog

LEPR

Ensembl ID

MGI ID

NCBI ID


Description

A point mutation was introduced to exon 19 (c.109052 G>T) via a recombineering strategy. Homozygous mutants are hyperphagic, low-activity, poorly cold-adapted, sterile and have enhanced fat conversion.

Research application

Leptin resistance,insulin resistance,obesity,and type 2 diabetes etc.

Status

Availability

Embryo cryopreservation


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