A20-hCD47

Export PDF

Strain Information

Validation Data

image.png

Figure 1. Expression of human CD47 on A20-hCD47 cells was confirmed by flow cytometry.  

A20-hCD47 cells and wild type A20 cells were stained with species-specific anti-CD47 antibodies.  FACS analysis shows that human CD47 but not mouse CD47 was exclusively detectable on A20-hCD47 cells.

image.png

Figure 2. In vivo tumor growth curves in humanized A20-hCD47 syngeneic model.

BALB/c mice were subcutaneously injected 5×105 A20-hCD47 cells compared with wild type A20 cells as control.  Tumor growth was monitored by measuring tumor size from day 11 after subcutaneous implantation.

Data shows that there were no significant differences between A20-hCD47 cells and wild type A20 cells in either tumorigenicity or tumor growth.

image.png

Figure 3. FACS analysis of CD47 expression on tumor cells derived from humanized A20-hCD47 syngeneic model with species-specific anti-CD47 antibodies.  

Data shows that human CD47 knock-in tumor exclusively express human CD47 but not mouse CD47.


Related Strain(s)

You may also like

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

Learn more
Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

Learn more