Braf-Flox

Nomenclature

C57BL/6JSmoc-Brafem1(flox)Smoc

Cat. NO.

NM-CKO-200073

Strain State

Embryo cryopreservation

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Gene Summary

Official Symbol
Braf

Model Description

These mice carry loxP sites flanking exon 5 of Braf gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Braf gene.
Research Application:Study on the correlation between meiosis and RET signal transduction in oocytes

Disease Connection

Melanoma
Thyroid Gland Papillary Carcinoma
Thyroid Gland Papillary Carcinoma
Skin Melanoma
Prostate Cancer
Langerhans-Cell Histiocytosis
Cardiofaciocutaneous Syndrome
cardiofaciocutaneous syndrome
Langerhans-Cell Histiocytosis

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Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

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