Pax7-IRES-Cre

Nomenclature

C57BL/6Smoc-Pax7em1(IRES-iCre)Smoc

Cat. NO.

NM-KI-200120

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol
Pax7

Synonyms

Pax-7

NCBI ID

18509

MGI ID

97491

Ensembl ID

ENSMUSG00000028736

Pubmed

Pax7

Human Ortholog

PAX7

Model Description

A IRES-iCre expression cassette was knocked into the Pax7 gene stop codon site. Pax7 is expressed in myogenic progenitor cells. Pax7 is essential for the myogenic potential, survival, and proliferation of myogenic progenitors. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing Pax7.
Research Application：Cre recombinase tool

Validation Data

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Fig. 1 Cre-mediated recombination in the embryo of Pax7Cre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the E12.5 Pax7Cre/+; Rosa26tdTomato/+ mouse embryo.

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Fig. 2 Cre-mediated recombination in the skeletal muscle of Pax7Cre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the skeletal muscle cells of Pax7Cre/+; Rosa26tdTomato/+ mouse.

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Fig. 3 Detection of tdTomato(red) in various tissues of Pax7Cre/+; Rosa26tdTomato/+ mice. Tdtomato expression can be detected in the hippocampus, cerebellum, gastric mucosa, trachea, bronchi, the muscular layer outside the trachea and intestine. Tdtomato expression can also be detected in individual cells of the pituitary gland, kidney, pancreas, spleen and uterus. (For more detailed information please contact our technical advisor.)


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