hC5AR1/C5AR2

Nomenclature

C57BL/6Smoc-C5ar1tm1(hC5AR1)C5ar2tm1(hC5AR2)/Smoc

Cat. NO.

NM-HU-2000018

Strain State

Repository Live

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Gene Summary

Gene Symbol
C5AR1

Gene Symbol
C5AR2

Model Description

The endogenous mouse C5ar1 and C5ar2 gene was replaced by human C5AR1 and hC5AR2 gene.
Research Application:Immunotherapy,drug screening

Validation Data

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Fig1. Detection of C5AR1 expression on myeloid cells in blood in homozygous hC5AR1 mice. 

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Fig2. Detection of C5AR1 expression on myeloid cells in bone morrow in homozygous hC5AR1 mice. 

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Fig3. Detection of hC5AR2 expression on myeloid cells in heterozygous hC5AR1/hC5AR2 mice. (Note: Anti-human C5L2 (C5AR2) antibody was cross-binding with mouse C5AR2)


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