hC5

Nomenclature

C57BL/6Smoc-Hcem1(hC5)Smoc

Cat. NO.

NM-HU-2000013

Strain State

Repository Live

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Gene Summary

Gene Symbol

Model Description

The endogenous mouse C5a gene was replaced by human C5 gene.
Research Application:Immunotherapy,cancer research,drug screening

Validation Data

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Fig1. Analysis of humanized C5 expression in serum in the humanized C5 mouse by ELISA. The homozygous KI mice express humanized C5 in serum after treated with LPS or NS (3mg/kg, i.p.) for 6 hours.


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Fig2. Analysis of humanized C5a expression in serum in the humanized C5 mouse by ELISA. The homozygous KI mice express humanized C5a in serum after treated with LPS or NS (3mg/kg, i.p.) for 6 hours.


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