Zbtb46-2A-CreERT2

Nomenclature

C57BL/6Smoc-Zbtb46em1(2A-CreERT2-WPRE-pA)Smoc

Cat. NO.

NM-KI-18021

Strain State

Embryo cryopreservation

Export PDF

Gene Summary

Gene Symbol
Zbtb46

Model Description

A 2A-CreERT2-WPRE-pA coexpression cassette is inserted befor the stop codon of mouse Zbtb46 gene via homologous recombination to establish a tamoxifen inducible Zbtb46-CreERT2 tool stain. This strain can be used to knockout target gene in Zbtb46+ cells after tamoxifen treatment when crossed with mice which carry loxp sites flanking target gene.
Research Application:Cre recombinase tool

Validation Data

image.png

Fig 1. Cre-mediated recombination in spleen of Zbtb46CreERT2/+; Rosa26tdTomato/+ mice.

image.png

Fig 2. Detection of tdTomato (red) in various tissues of Zbtb46CreERT2/+; Rosa26tdTomato/+. Expression tissues include: liver, salivary gland, pituitary gland, adrenal gland, kidney, pancreas, spleen, testis, thymus. A few cells expressed in cerebellum, spinal cord, heart, brown fat, small intestine, colon, muscle, skin. (6.5-8 weeks old, male) (For more detailed information please contact our technical advisor.) 


You may also like

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

Learn more
Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

Learn more