R26-pVillin1-hCYP3A4-IRES-tdTomato(FVB)
Nomenclature
FVB-Gt(ROSA)26Sorem1(Gut-CYP3A4-IRES-tdTomato)Smoc
Cat. NO.
NM-KI-18033
Strain State
Embryo cryopreservation
Gene Summary
Gene Symbol
Gt(ROSA)26Sor
Model Description
Intestinal expression of the CYP3A enzyme in the human body can cause significant intestinal metabolism of the compound, resulting in impaired drug absorption. This knock-in model was generated by inserting the human CYP3A4 cDNA driven by the Villin1 promoter together with the IRES-tdTomato reporter gene into mosue Rosa26 site, which can be crossed with the Cyp3a13 gene knockout and other Cyp3a family genes knockout mice to obtain intestinal-expressed CYP3A4 humanized mouse model in order to determine the contribution of intestinal metabolism to the absorption and distribution of test article.
Research Application：metabolism
*Literature published using this strain should indicate: R26-pVillin1-hCYP3A4-IRES-tdTomato(FVB) mice (Cat. NO. NM-KI-18033) were purchased from Shanghai Model Organisms Center, Inc..
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On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
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