HBV-Tg

Nomenclature

B6.Cg-Tg(HBV)Smoc

Cat. NO.

NM-TG-00003

Strain State

Repository Live

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Gene Summary

Gene Symbol

Synonyms

Hepatitis B virus isolate C8 complete genome

NCBI ID

AF461363

MGI ID

Null

Ensembl ID

Null

Pubmed

Model Description

Full-length HBV genome (adrsubtype,C genotype) was used to establish the transgenic mice. HBsAg was positive in transgenic mice serum; no serum HBeAg anti-HBs, anti-HBe, or antiHBc was detected. No anti-HBs or anti-HBe was detected in the polyethylene gly.
Research Application：HBV

Validation Data

HBV-1.png

Fig1. Immuno-histochemical staining of HBsAg in the liver and kidney sections of #59 transgenic mice. Sections of liver (A) or kidney (B) tissues from #59 transgenic mice were stained for HBsAg.

HBV-2.png

Fig2.  Immuno-histochemical staining of HBcAg in the liver and kidney sections of #59 transgenic mice.

Sections of liver (A) or kidney (B) tissues from #59 transgenic mice were stained for HBcAg.

HBV-3.png

Tab1. Eight Selected Genes From the Kidney of #59 Mice Assayed by Microarray and Real-Time PCR

HBV-4.png

Fig3.  Dot blot immunoassay of complement C3 component in mouse serum and kidney tissue extract.

Publications

Expression of hepatitis B virus proteins in transgenic mice alters lipid metabolism and induces oxidative stress in the liver
References：JOURNAL OF HEPATOLOGY

An Altered Pattern of Liver Apolipoprotein A-I Isoforms Is Implicated in Male Chronic Hepatitis B Progression
References：ACS Publications

Hepatitis B virus (HBV) surface antigen interacts with and promotes cyclophilin a secretion: possible link to pathogenesis of HBV infection
References：Journal of Virology

Proteomic analysis of hepatitis B surface antigen positive transgenic mouse liver and decrease of cyclophilin A
References：Journal of Medical Virology

Transcriptional analysis of immune-related genes in dendritic cells from hepatitis B surface antigen (HBsAg)-positive transgenic mice and regulation of Fc gamma receptor IIB by HBsAg-anti-HBs complex
References：Journal of Medical Virology

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